Darragh Duffy

Overview

Best Publications

• Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients.

  Jérôme Hadjadj;Nader Yatim;Laura Barnabei;Aurélien Corneau

  3039
  Citations

• Autoantibodies against type I IFNs in patients with life-threatening COVID-19.

  Paul Bastard;Paul Bastard;Paul Bastard;Lindsey B. Rosen;Qian Zhang;Eleftherios Michailidis

  2660
  Citations

• Inborn errors of type I IFN immunity in patients with life-threatening COVID-19

  Qian Zhang;Paul Bastard;Paul Bastard;Zhiyong Liu;Jérémie Le Pen

  2199
  Citations

• Mitochondrial double-stranded RNA triggers antiviral signalling in humans

  Ashish Dhir;Somdutta Dhir;Lukasz S. Borowski;Lukasz S. Borowski;Laura Jimenez

  597
  Citations

• Autoantibodies neutralizing type I IFNs are present in ~ 4% of uninfected individuals over 70 years old and account for ~ 20% of COVID-19 deaths.

  Paul Bastard;Adrian Gervais;Adrian Gervais;Tom Le Voyer;Tom Le Voyer;Jérémie Rosain;Jérémie Rosain

  592
  Citations

• Genetic Adaptation and Neandertal Admixture Shaped the Immune System of Human Populations.

  Hélène Quach;Maxime Rotival;Maxime Rotival;Julien Pothlichet;Julien Pothlichet;Yong-Hwee Eddie Loh;Yong-Hwee Eddie Loh

  495
  Citations

• Detection of interferon alpha protein reveals differential levels and cellular sources in disease.

  Mathieu P. Rodero;Jérémie Decalf;Jérémie Decalf;Vincent Bondet;Vincent Bondet;David Hunt;David Hunt

  390
  Citations

• Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors.

  Etienne Patin;Milena Hasan;Jacob Bergstedt;Vincent Rouilly

  324
  Citations

• The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

  Unknown

  263
  Citations

• Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli.

  Darragh Duffy;Darragh Duffy;Vincent Rouilly;Valentina Libri;Milena Hasan

  254
  Citations

• Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children

  Marie-Louise Frémond;Marie-Louise Frémond;Marie-Louise Frémond;Mathieu Paul Rodero;Mathieu Paul Rodero;Nadia Jeremiah;Alexandre Belot

  235
  Citations

• Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges

  Barbara Piasecka;Darragh Duffy;Alejandra Urrutia;Alejandra Urrutia;Helene Quach

  227
  Citations

• SARS-CoV-2 infection induces the dedifferentiation of multiciliated cells and impairs mucociliary clearance.

  Rémy Robinot;Rémy Robinot;Mathieu Hubert;Mathieu Hubert;Guilherme Dias de Melo;Françoise Lazarini;Françoise Lazarini

  225
  Citations

• JAK inhibitor improves type I interferon induced damage: proof of concept in dermatomyositis.

  Leandro Ladislau;Leandro Ladislau;Xavier Suárez-Calvet;Xavier Suárez-Calvet;Ségolène Toquet;Océane Landon-Cardinal

  224
  Citations

• Type I interferon-mediated autoinflammation due to DNase II deficiency

  Mathieu P. Rodero;Alessandra Tesser;Eva Bartok;Gillian I. Rice

  223
  Citations

• Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth.

  Clémence Hollande;Clémence Hollande;Jeremy Boussier;James Ziai;Tamaki Nozawa

  209
  Citations

• Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines

  Petar Scepanovic;Petar Scepanovic;Cécile Alanio;Christian Hammer;Christian Hammer;Christian Hammer;Flavia Hodel;Flavia Hodel

  205
  Citations

• Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling.

  Alice Lepelley;Maria José Martin-Niclós;Melvin Le Bihan;Joseph A. Marsh

  205
  Citations

• Impaired type I interferon activity and exacerbated inflammatory responses in severe Covid-19 patients

  Jerome Hadjadj;Nader Yatim;Laura Barnabei;Aurelien Corneau

  199
  Citations

• Overview of STING-Associated Vasculopathy with Onset in Infancy (SAVI) Among 21 Patients.

  Marie-Louise Frémond;Marie-Louise Frémond;Alice Hadchouel;Alice Hadchouel;Alice Hadchouel;Laureline Berteloot;Isabelle Melki;Isabelle Melki

  193
  Citations

• CD56brightCD16+ NK Cells: A Functional Intermediate Stage of NK Cell Differentiation

  Vivien Béziat;Vivien Béziat;Darragh Duffy;Darragh Duffy;Stéphanie Nguyen Quoc;Stéphanie Nguyen Quoc;Magali Le Garff-Tavernier;Magali Le Garff-Tavernier

  188
  Citations

• Neutrophils Transport Antigen from the Dermis to the Bone Marrow, Initiating a Source of Memory CD8+ T Cells

  Darragh Duffy;Darragh Duffy;Hélène Perrin;Hélène Perrin;Valérie Abadie;Valérie Abadie;Nora Benhabiles

  187
  Citations

• Nanoparticle-Based Targeting of Vaccine Compounds to Skin Antigen-Presenting Cells By Hair Follicles and their Transport in Mice

  Brice Mahe;Annika Vogt;Christelle Liard;Darragh Duffy

  169
  Citations