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Biology and Biochemistry

D-Index
61
Citations
17730
World Ranking
11173
National Ranking
860

Overview

Gillian I. Rice is affiliated with the University of Manchester in the United Kingdom. Their research primarily spans the disciplines of Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology. The subfields of their work include Molecular Biology, Immunology, Rheumatology, Hematology, and Genetics.

The scientist's research focuses on several key topics related to immune system functioning and genetic disorders. These include interferon and immune responses, Systemic Lupus Erythematosus Research, inflammasome and immune disorders, RNA regulation and disease, RNA research and splicing, immunodeficiency and autoimmune disorders, and mechanisms of RNA and protein synthesis.

Gillian I. Rice has contributed to numerous publications, with a consistent presence in specialized venues. Frequent publication venues include Journal of Clinical Immunology, The Journal of Experimental Medicine, Nature Genetics, bioRxiv (Cold Spring Harbor Laboratory), and The American Journal of Human Genetics.

Among their recent papers are:

  • Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling, 2020, The Journal of Experimental Medicine
  • Overview of STING-Associated Vasculopathy with Onset in Infancy (SAVI) Among 21 Patients, 2020, The Journal of Allergy and Clinical Immunology In Practice
  • cGAS-mediated induction of type I interferon due to inborn errors of histone pre-mRNA processing, 2020, Nature Genetics
  • Genetic and phenotypic spectrum associated with IFIH1 gain-of-function, 2020, Human Mutation
  • Contribution of rare and predicted pathogenic gene variants to childhood-onset lupus: a large, genetic panel analysis of British and French cohorts, 2020, The Lancet Rheumatology

Their frequent co-authors consist of Yanick J. Crow, Luís Seabra, Marie-Louise Frémond, Brigitte Bader-Meunier, and Alice Lepelley. This network of collaboration reflects ongoing partnerships predominantly within the immunology and genetic research communities.

Best Publications

  • HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

    David C. Goldstone;Valerie Ennis-Adeniran;Joseph J. Hedden;Harriet C. T. Groom

  • Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type I interferon signature

    Gillian I. Rice;Paul R. Kasher;Gabriella M A Forte;Niamh M. Mannion

  • Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response.

    Gillian I Rice;Jacquelyn Bond;Aruna Asipu;Rebecca L Brunette

  • Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

    Gillian I. Rice;Gillian I. Rice;Daniel A. Thomas;Peter J. Grant;Anthony J. Turner

  • Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1.

    Yanick J. Crow;Diana S. Chase;Johanna Lowenstein Schmidt;Marcin Szynkiewicz

  • Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling

    Gillian I Rice;Yoandris del Toro Duany;Yoandris del Toro Duany;Emma M Jenkinson;Gabriella M A Forte

  • Mitochondrial double-stranded RNA triggers antiviral signalling in humans

    Ashish Dhir;Somdutta Dhir;Lukasz S. Borowski;Lukasz S. Borowski;Laura Jimenez

  • Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation

    Xianqin Zhang;Dusan Bogunovic;Béatrice Payelle-Brogard;Véronique Francois-Newton

  • Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations

    Nadia Jeremiah;Bénédicte Neven;Matteo Gentili;Isabelle Callebaut

  • Clinical and Molecular Phenotype of Aicardi-Goutières Syndrome

    Gillian Rice;Teresa Patrick;Rekha Parmar;Claire F Taylor

  • Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study

    Gillian I Rice;Gabriella M A Gm Forte;Marcin Szynkiewicz;Diana S Chase

  • Heterozygous Mutations in TREX1 Cause Familial Chilblain Lupus and Dominant Aicardi-Goutières Syndrome

    Gillian Rice;William G. Newman;John Dean;Teresa Patrick

  • Detection of interferon alpha protein reveals differential levels and cellular sources in disease.

    Mathieu P. Rodero;Jérémie Decalf;Jérémie Decalf;Vincent Bondet;Vincent Bondet;David Hunt;David Hunt

  • SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells.

    Benjamin Descours;Alexandra Cribier;Christine Chable-Bessia;Diana Ayinde

  • Mutations in CTC1, encoding conserved telomere maintenance component 1, cause Coats plus

    Beverley H Anderson;Paul R Kasher;Josephine Mayer;Marcin Szynkiewicz

  • Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature.

    Tracy A. Briggs;Gillian I. Rice;Sarah Daly;Jill Urquhart

  • Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children

    Marie-Louise Frémond;Marie-Louise Frémond;Marie-Louise Frémond;Mathieu Paul Rodero;Mathieu Paul Rodero;Nadia Jeremiah;Alexandre Belot

  • Circulating Activities of Angiotensin-Converting Enzyme, Its Homolog, Angiotensin-Converting Enzyme 2, and Neprilysin in a Family Study

    Gillian I. Rice;Amy L. Jones;Peter J. Grant;Angela M. Carter

  • ACEH/ACE2 is a novel mammalian metallocarboxypeptidase and a homologue of angiotensin-converting enzyme insensitive to ACE inhibitors.

    Anthony J Turner;Sarah R Tipnis;Jodie L Guy;Gillian I Rice

  • A Specific IFIH1 Gain-of-Function Mutation Causes Singleton-Merten Syndrome

    Frank Rutsch;Mary MacDougall;Changming Lu;Insa Buers

Frequent Co-Authors

Yanick J. Crow
Yanick J. Crow Université Paris Cité
Darragh Duffy
Darragh Duffy Institut Pasteur
Bénédicte Neven
Bénédicte Neven Université Paris Cité
Pierre Lebon
Pierre Lebon Université Paris Cité
Ian N. Bruce
Ian N. Bruce University of Manchester
Frédéric Rieux-Laucat
Frédéric Rieux-Laucat Université Paris Cité
Flore Rozenberg
Flore Rozenberg Université Paris Cité
Russell C. Dale
Russell C. Dale University of Sydney
Stéphane Blanche
Stéphane Blanche Université Paris Cité
Peter J. Grant
Peter J. Grant University of Leeds

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