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Medicine

D-Index
80
Citations
26469
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17014
National Ranking
8533

Overview

Mark C. Chappell is affiliated with Wake Forest University in the United States and has contributed extensively to the field of medicine, with a specific focus on cardiology and cardiovascular medicine. Their research spans various domains including infectious diseases, endocrinology, diabetes and metabolism, molecular biology, and nephrology.

Their main research topics include:

  • Renin-Angiotensin System Studies
  • Hormonal Regulation and Hypertension
  • COVID-19 Clinical Research Studies
  • SARS-CoV-2 and COVID-19 Research
  • Sepsis Diagnosis and Treatment
  • Receptor Mechanisms and Signaling
  • Renal function and acid-base balance

Chappell's recent published papers illustrate their involvement in addressing cardiovascular consequences of COVID-19 and related biochemical mechanisms. Notable publications include:

  • "COVID-19, ACE2, and the cardiovascular consequences," 2020, American Journal of Physiology-Heart and Circulatory Physiology
  • "Diet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model," 2021, Microbiome
  • "Concerns on the Specificity of Commercial ELISAs for the Measurement of Angiotensin (1-7) and Angiotensin II in Human Plasma," 2021, Hypertension
  • "A pilot study to assess the circulating renin-angiotensin system in COVID-19 acute respiratory failure," 2021, American Journal of Physiology-Lung Cellular and Molecular Physiology
  • "Association of Active Renin Content With Mortality in Critically Ill Patients: A Post hoc Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) Trial*," 2023, Critical Care Medicine

Chappell frequently publishes in the following venues:

  • Hypertension
  • Critical Care
  • Peptides
  • American Journal of Physiology-Lung Cellular and Molecular Physiology
  • Journal of Hypertension

Collaborations are a substantial component of Chappell's research activity. Their frequent co-authors include:

  • Christopher L. Schaich
  • Ashish K. Khanna
  • Andrew M. South
  • Debra I. Diz
  • Nancy T. Pirro

The breadth of Chappell's work within medicine, especially concerning the renin-angiotensin system and its role in hypertension and infectious diseases such as COVID-19, reflects an interdisciplinary approach integrating molecular biology and clinical research.

Best Publications

  • A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus–induced lung injury

    Keiji Kuba;Yumiko Imai;Shuan Rao;Hong Gao

  • Angiotensin-converting enzyme 2 is an essential regulator of heart function

    Michael A. Crackower;Renu Sarao;Renu Sarao;Gavin Y. Oudit;Gavin Y. Oudit;Chana Yagil

  • Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2.

    Carlos M. Ferrario;Jewell Jessup;Mark C. Chappell;David B. Averill

  • COVID-19, ACE2, and the cardiovascular consequences.

    Andrew Michael South;Debra Diz;Mark C. Chappell

  • Counterregulatory Actions of Angiotensin-(1-7)

    Carlos M. Ferrario;Mark C. Chappell;E. Ann Tallant;K. Bridget Brosnihan

  • Inhibition of Early Atherogenesis by Losartan in Monkeys With Diet-Induced Hypercholesterolemia

    William B. Strawn;Mark C. Chappell;Richard H. Dean;Salah Kivlighn

  • Metabolism of Angiotensin-(1–7) by Angiotensin-Converting Enzyme

    Mark C. Chappell;Nancy T. Pirro;Angela Sykes;Carlos M. Ferrario

  • Attenuation of pulmonary ACE2 activity impairs inactivation of des-Arg9 bradykinin/BKB1R axis and facilitates LPS-induced neutrophil infiltration.

    Chhinder P Sodhi;Christine Wohlford-Lenane;Yukihiro Yamaguchi;Thomas Prindle

  • Estrogen Regulation of Angiotensin-Converting Enzyme mRNA

    P. E. Gallagher;Ping Li;J. R. Lenhart;M. C. Chappell

  • Angiotensin-(1-7) augments bradykinin-induced vasodilation by competing with ACE and releasing nitric oxide

    P Li;M C Chappell;C M Ferrario;K B Brosnihan

  • Ectodomain shedding of angiotensin converting enzyme 2 in human airway epithelia

    Hong Peng Jia;Dwight C. Look;Ping Tan;Lei Shi

  • Effects of renin-angiotensin system blockade on renal angiotensin-(1-7) forming enzymes and receptors

    Carlos M. Ferrario;Jewell Jessup;Patricia E. Gallagher;David B. Averill

  • Biochemical evaluation of the renin-angiotensin system: the good, bad, and absolute?

    Mark C. Chappell

  • Vasodepressor Actions of Angiotensin-(1–7) Unmasked During Combined Treatment With Lisinopril and Losartan

    Shridhar N. Iyer;Mark C. Chappell;David B. Averill;Debra I. Diz

  • Angiotensin-(1–7) Contributes to the Antihypertensive Effects of Blockade of the Renin-Angiotensin System

    Shridhar N. Iyer;Carlos M. Ferrario;Mark C. Chappell

  • Angiotensin II-mediated oxidative stress and inflammation mediate the age-dependent cardiomyopathy in ACE2 null mice

    Gavin Y. Oudit;Zamaneh Kassiri;Mikin P. Patel;Mark Chappell

  • Identification of angiotensin-(1-7) in rat brain. Evidence for differential processing of angiotensin peptides.

    M C Chappell;K B Brosnihan;D I Diz;C M Ferrario

  • Emerging Evidence for a Functional Angiotensin-Converting Enzyme 2-Angiotensin-(1-7)-Mas Receptor Axis: More Than Regulation of Blood Pressure?

    Mark C. Chappell

  • Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytes.

    Patricia E. Gallagher;Mark C. Chappell;Carlos M. Ferrario;E. Ann Tallant

  • Angiotensin-(1-7) prevents activation of NADPH oxidase and renal vascular dysfunction in diabetic hypertensive rats.

    Ibrahim F. Benter;Mariam H.M. Yousif;Gursev S. Dhaunsi;Jaspal Kaur

Frequent Co-Authors

Debra I. Diz
Debra I. Diz Wake Forest University
Carlos M. Ferrario
Carlos M. Ferrario Wake Forest University
Detlev Ganten
Detlev Ganten Max Delbrück Center for Molecular Medicine
Josef M. Penninger
Josef M. Penninger University of British Columbia
Gavin Y. Oudit
Gavin Y. Oudit University of Alberta
Dalane W. Kitzman
Dalane W. Kitzman Wake Forest University
Peter H. Backx
Peter H. Backx York University
Kazuo Kitamura
Kazuo Kitamura University of Miyazaki
Paul B. McCray
Paul B. McCray University of Iowa
Donald W. Jacobsen
Donald W. Jacobsen Cleveland Clinic Lerner College of Medicine

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