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Molecular Biology

D-Index
47
Citations
11518
World Ranking
2722
National Ranking
66

Overview

Carl R. Walkley is affiliated with the St Vincents Institute of Medical Research in Australia. Their research primarily focuses on biochemistry, genetics, and molecular biology, with notable contributions to medicine. The scientist's work spans several subfields, including molecular biology, hematology, immunology, cardiology and cardiovascular medicine, and epidemiology.

The main topics of Carl R. Walkley's research cover aspects of RNA regulation and disease, RNA research and splicing, acute myeloid leukemia, interferon and immune responses, CRISPR and genetic engineering, viral infections and immunology research, and RNA modifications in cancer.

Frequent coauthors in their publications include Alistair M. Chalk, Jacki Heraud-Farlow, Monique Smeets, Ankita Goradia, and Zhen Liang.

Significant recent papers by Carl R. Walkley include:

  • ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis, 2022, Nature
  • Direct identification of A-to-I editing sites with nanopore native RNA sequencing, 2022, Nature Methods
  • ADAR1p150 prevents MDA5 and PKR activation via distinct mechanisms to avert fatal autoinflammation, 2023, Molecular Cell
  • What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs, 2020, Open Biology
  • ADAR1-Dependent RNA Editing Promotes MET and iPSC Reprogramming by Alleviating ER Stress, 2020, Cell Stem Cell

Carl R. Walkley has frequently published in venues such as bioRxiv (Cold Spring Harbor Laboratory), Experimental Hematology, Nature Neuroscience, Nature Communications, and Blood.

Best Publications

  • Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis

    Trista E. North;Wolfram Goessling;Wolfram Goessling;Carl R. Walkley;Claudia Lengerke

  • RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

    Brian J. Liddicoat;Robert Piskol;Alistair M. Chalk;Alistair M. Chalk;Gokul Ramaswami

  • Dynamic landscape and regulation of RNA editing in mammals

    Meng How Tan;Qin Li;Raghuvaran Shanmugam;Robert Piskol

  • A Microenvironment-Induced Myeloproliferative Syndrome Caused by Retinoic Acid Receptor γ Deficiency

    Carl R Walkley;Gemma Olsen;Sebastian Dworkin;Stewart Alastair Fabb

  • ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling.

    Jochen C Hartner;Carl R Walkley;Jun Lu;Jun Lu;Stuart H Orkin

  • Rb Regulates Interactions between Hematopoietic Stem Cells and Their Bone Marrow Microenvironment

    Carl R. Walkley;Jeremy M. Shea;Natalie A. Sims;Louise E. Purton

  • Developmental and species-divergent globin switching are driven by BCL11A

    Vijay G. Sankaran;Jian Xu;Tobias Ragoczy;Gregory C. Ippolito

  • Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease

    Carl R. Walkley;Rameez Qudsi;Vijay G. Sankaran;Jennifer A. Perry

  • Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity

    Sandra Galic;Morgan D. Fullerton;Jonathan D. Schertzer;Sarah Sikkema

  • Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma

    David M. Thomas;Sandra A. Johnson;Natalie A. Sims;Melanie K. Trivett

  • RARγ is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation

    Louise E. Purton;Sebastian Dworkin;Gemma Haines Olsen;Carl R. Walkley;Carl R. Walkley

  • MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation

    Gretchen Poortinga;Katherine M Hannan;Hayley Snelling;Carl R Walkley;Carl R Walkley

  • Cells of origin in osteosarcoma: mesenchymal stem cells or osteoblast committed cells?

    Anthony J. Mutsaers;Carl R. Walkley;Carl R. Walkley

  • Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs

    Carl R. Walkley;Carl R. Walkley;Jin Billy Li

  • Deciphering Hematopoietic Stem Cells in Their Niches: A Critical Appraisal of Genetic Models, Lineage Tracing, and Imaging Strategies

    Chacko Joseph;Chacko Joseph;Julie M. Quach;Carl R. Walkley;Carl R. Walkley;Steven W. Lane

  • Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis

    Vijay G. Sankaran;Stuart H. Orkin;Carl R. Walkley

  • Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment

    Sofie Singbrant;Megan R. Russell;Tanja Jovic;Brian Liddicoat

  • Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells

    Carl R. Walkley;Matthew L. Fero;Wei Ming Chien;Louise E. Purton;Louise E. Purton

  • BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells

    Emma K Baker;Scott Taylor;Ankita Gupte;Phillip P Sharp

  • Generation and analysis of Siah2 mutant mice.

    Ian J Frew;Vicki E Hammond;Ross A Dickins;Julian Michael Warner Quinn

Frequent Co-Authors

Stuart H. Orkin
Stuart H. Orkin Harvard University
T. John Martin
T. John Martin St Vincents Institute of Medical Research
Natalie A. Sims
Natalie A. Sims St Vincents Institute of Medical Research
Vijay G. Sankaran
Vijay G. Sankaran Harvard University
Grant A. McArthur
Grant A. McArthur Peter MacCallum Cancer Centre
Andrew C.W. Zannettino
Andrew C.W. Zannettino University of Adelaide
Jin Billy Li
Jin Billy Li Stanford University
Sarah M. Russell
Sarah M. Russell Peter MacCallum Cancer Centre
Jun Lu
Jun Lu Zhejiang University
David D.L. Bowtell
David D.L. Bowtell Peter MacCallum Cancer Centre

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