World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
123
Citations
61856
World Ranking
3321
National Ranking
31

Research.com Recognitions

  • 2021 - Breakthrough Prize in Life Sciences for discovering that fetal DNA is present in maternal blood and can be used for the prenatal testing of trisomy 21 and other genetic disorders.
  • 2014 - King Faisal Prize
  • 2013 - Member of the National Academy of Sciences

Overview

Y.M. Dennis Lo is affiliated with the Chinese University of Hong Kong in China and has a significant research footprint in the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work predominantly focuses on Cancer Research, Molecular Biology, Pediatrics, Perinatology and Child Health, Oncology, and Surgery. The main topics addressed in their research include Cancer Genomics and Diagnostics, Prenatal Screening and Diagnostics, Epigenetics and DNA Methylation, Renal and related cancers, Single-cell and spatial transcriptomics, Viral-associated cancers and disorders, and Cholangiocarcinoma and Gallbladder Cancer Studies.

Their recent publications include the following:

  • Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies (2021), published in Science
  • Plasma DNA End-Motif Profiling as a Fragmentomic Marker in Cancer, Pregnancy, and Transplantation (2020), published in Cancer Discovery
  • Circulating biomarkers in the diagnosis and management of hepatocellular carcinoma (2022), published in Nature Reviews Gastroenterology & Hepatology
  • The Biology of Cell-free DNA Fragmentation and the Roles of DNASE1, DNASE1L3, and DFFB (2020), published in The American Journal of Human Genetics
  • The Nexus of cfDNA and Nuclease Biology (2021), published in Trends in Genetics

Frequent co-authors collaborating with Y.M. Dennis Lo include:

  • Peiyong Jiang
  • K.C. Allen Chan
  • Rossa W. K. Chiu
  • Suk Hang Cheng
  • W.K. Lam

The scientist has published regularly in several key academic venues, including:

  • Clinical Chemistry
  • Proceedings of the National Academy of Sciences
  • Genome Research
  • Prenatal Diagnosis
  • The American Journal of Human Genetics

Y.M. Dennis Lo has received notable awards reflecting contributions to the scientific community. These include the Breakthrough Prize in Life Sciences in 2021, recognizing the discovery that fetal DNA is present in maternal blood and can be used for prenatal testing of trisomy 21 and other genetic disorders. The King Faisal Prize was awarded in 2014, and in 2013, they were elected as a Member of the National Academy of Sciences.

Best Publications

  • Presence of fetal DNA in maternal plasma and serum

    Y. M. Dennis Lo;Noemi Corbetta;Paul F. Chamberlain;Vik Rai

  • Quantitative Analysis of Fetal DNA in Maternal Plasma and Serum: Implications for Noninvasive Prenatal Diagnosis

    Y. M. Dennis Lo;Mark S.C. Tein;Tze K. Lau;Christopher J. Haines

  • Rapid Clearance of Fetal DNA from Maternal Plasma

    Y. M. Dennis Lo;Jun Zhang;Tse N. Leung;Tze K. Lau

  • Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma.

    Rossa W. K. Chiu;K. C. Allen Chan;Yuan Gao;Virginia Y. M. Lau

  • Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus

    Y. M. Dennis Lo;K. C. Allen Chan;Hao Sun;Eric Z. Chen

  • Detection and characterization of placental microRNAs in maternal plasma.

    Stephen S C Chim;Tristan K F Shing;Emily C W Hung;Tak Yeung Leung

  • Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: Large scale validity study

    Rossa W K Chiu;Ranjit Akolekar;Yama W L Zheng;Tak Y Leung

  • Quantitative Analysis of Cell-free Epstein-Barr Virus DNA in Plasma of Patients with Nasopharyngeal Carcinoma

    Y. M.Dennis Lo;Lisa Y.S. Chan;Kwok Wai Lo;Sing Fai Leung

  • Size Distributions of Maternal and Fetal DNA in Maternal Plasma

    K. C.Allen Chan;Jun Zhang;Angela B.Y. Hui;Nathalie Wong

  • Stability of Endogenous and Added RNA in Blood Specimens, Serum, and Plasma

    Nancy B.Y. Tsui;Enders K.O. Ng;Y.M. Dennis Lo

  • Detection of Aberrant p16 Methylation in the Plasma and Serum of Liver Cancer Patients

    Ivy H.N. Wong;Y. M.Dennis Lo;Jun Zhang;Choong Tsek Liew

  • Molecular Evolution of the SARS Coronavirus, during the Course of the SARS Epidemic in China

    Jian Feng He;Guo Wen Peng;Jun Min;De Wen Yu

  • Plasma DNA tissue mapping by genome-wide methylation sequencing for noninvasive prenatal, cancer, and transplantation assessments.

    Kun Sun;Peiyong Jiang;K. C. Allen Chan;John Wong

  • Effects of early corticosteroid treatment on plasma SARS-associated Coronavirus RNA concentrations in adult patients.

    Nelson Lee;K.C. Allen Chan;David S. Hui;Enders K.O. Ng

  • Quantitative Abnormalities of Fetal DNA in Maternal Serum in Preeclampsia

    Y.M. Dennis Lo;Tse N. Leung;Mark S.C. Tein;Ian L. Sargent

  • Predominant Hematopoietic Origin of Cell-free DNA in Plasma and Serum after Sex-mismatched Bone Marrow Transplantation

    Yanni Y N Lui;Ki Wai Chik;Rossa W K Chiu;Cheong Yip Ho

  • Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients

    Peiyong Jiang;Carol W.M. Chan;K. C.Allen Chan;Suk Hang Cheng

  • Analysis of Plasma Epstein-Barr Virus DNA to Screen for Nasopharyngeal Cancer.

    K C Allen Chan;John K S Woo;Ann King;Benny C Y Zee

  • Digital PCR for the molecular detection of fetal chromosomal aneuploidy

    Y. M. Dennis Lo;Fiona M. F. Lun;K. C. Allen Chan;Nancy B. Y. Tsui

  • Plasma placental RNA allelic ratio permits noninvasive prenatal chromosomal aneuploidy detection

    Y M Dennis Lo;Nancy B Y Tsui;Rossa W K Chiu;Tze K Lau

Frequent Co-Authors

Rossa W.K. Chiu
Rossa W.K. Chiu Chinese University of Hong Kong
Peiyong Jiang
Peiyong Jiang Chinese University of Hong Kong
Anthony T.C. Chan
Anthony T.C. Chan Chinese University of Hong Kong
Philip J. Johnson
Philip J. Johnson University of Liverpool
Hao Sun
Hao Sun Chinese University of Hong Kong
Benny Chung-ying Zee
Benny Chung-ying Zee Chinese University of Hong Kong
Paul K.S. Chan
Paul K.S. Chan Chinese University of Hong Kong
John Wong
John Wong University of Hong Kong
Kypros H. Nicolaides
Kypros H. Nicolaides King's College London
Paul B.S. Lai
Paul B.S. Lai Chinese University of Hong Kong

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