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Biology and Biochemistry

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51
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15100
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16958
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1336

Overview

David H. Wyllie is affiliated with Public Health England in the United Kingdom. Their research primarily spans Medicine and Biochemistry, Genetics and Molecular Biology, focusing on several subfields including Infectious Diseases, Epidemiology, Molecular Biology, Genetics, and Immunology.

Their recent work includes contributions to research on SARS-CoV-2 and COVID-19, with key topics covering SARS-CoV-2 detection and testing, COVID-19 clinical research studies, Mycobacterium research and diagnosis, gut microbiota and health, COVID-19 epidemiological studies, and tuberculosis research and epidemiology.

  • Dynamic linkage of COVID-19 test results between Public Health England's Second Generation Surveillance System and UK Biobank (2020, Microbial Genomics)
  • SARS-CoV-2 responsive T cell numbers and anti-Spike IgG levels are both associated with protection from COVID-19: A prospective cohort study in keyworkers (2020, bioRxiv [Cold Spring Harbor Laboratory])
  • Identification of host-pathogen-disease relationships using a scalable multiplex serology platform in UK Biobank (2022, Nature Communications)
  • Use of dried blood spot samples for SARS-CoV-2 antibody detection using the Roche Elecsys ® high throughput immunoassay (2021, Journal of Clinical Virology)
  • Accuracy of UK Rapid Test Consortium (UK-RTC) "AbC-19 Rapid Test" for detection of previous SARS-CoV-2 infection in key workers: test accuracy study (2020, BMJ)

Frequent collaborators include:

  • Ranya Mulchandani
  • Isabel Oliver
  • Tim Brooks
  • Derrick W. Crook
  • Hayley E. Jones

Publishing venues regularly featuring their work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Infection
  • Scientific Reports
  • Microbial Genomics
  • Nature Communications

David H. Wyllie's research addresses key questions in infectious disease epidemiology and molecular biology, particularly related to the COVID-19 pandemic. The scientist's studies often investigate immune responses, antibody detection methods, and population-level disease surveillance, with a notable emphasis on linking clinical and laboratory data to better understand infection dynamics.

Best Publications

  • Erratum: Corrigendum: The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

    A D Douglas;A R Williams;J J Illingworth;G Kamuyu

  • Regulation of Toll-like receptors in human monocytes and dendritic cells.

    Alberto Visintin;Alessandra Mazzoni;Jessica H. Spitzer;David H. Wyllie

  • Diverse Sources of C. difficile Infection Identified on Whole-Genome Sequencing

    D W Eyre;M L Cule;D J Wilson;D Griffiths

  • Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis.

    P Bradley;N C Gordon;T M Walker;L Dunn

  • Correction: Corrigendum: Rapid antibiotic-resistance predictions from genome sequence data for Staphylococcus aureus and Mycobacterium tuberculosis

    Phelim Bradley;N. Claire Gordon;Timothy M. Walker;Laura Dunn

  • Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing.

    Caroline Allix-Béguec;Irena Arandjelovic

  • Single nucleotide polymorphisms in the human interleukin-1B gene affect transcription according to haplotype context

    Hongmin Chen;Leon M. Wilkins;Nazneen Aziz;Christopher Cannings

  • Evidence for an Accessory Protein Function for Toll-Like Receptor 1 in Anti-Bacterial Responses

    D. H. Wyllie;E. Kiss-Toth;A. Visintin;S. C. Smith

  • Rapid, comprehensive, and affordable mycobacterial diagnosis with whole-genome sequencing: a prospective study

    Louise J Pankhurst;Carlos del Ojo Elias;Antonina A Votintseva;Timothy M Walker

  • Same-Day Diagnostic and Surveillance Data for Tuberculosis via Whole-Genome Sequencing of Direct Respiratory Samples.

    Antonina A. Votintseva;Phelim Bradley;Louise Pankhurst;Carlos del Ojo Elias

  • Human Tribbles, a Protein Family Controlling Mitogen-activated Protein Kinase Cascades

    Endre Kiss-Toth;Stephanie M. Bagstaff;Hye Y. Sung;Veronika Jozsa

  • Predicting antimicrobial susceptibilities for Escherichia coli and Klebsiella pneumoniae isolates using whole genomic sequence data.

    N. Stoesser;E. M. Batty;D. W. Eyre;M. Morgan

  • Evolutionary History of the Global Emergence of the Escherichia coli Epidemic Clone ST131

    Nicole Stoesser;Anna E. Sheppard;Louise Pankhurst;Nicola De Maio

  • The blood-stage malaria antigen PfRH5 is susceptible to vaccine-inducible cross-strain neutralizing antibody

    Alexander D. Douglas;Andrew R. Williams;Joseph J. Illingworth;Gathoni Kamuyu

  • Effects of control interventions on Clostridium difficile infection in England: an observational study

    Kate E Dingle;Kate E Dingle;Kate E Dingle;Xavier Didelot;T Phuong Quan;T Phuong Quan;T Phuong Quan;David W Eyre;David W Eyre

  • Mortality after Staphylococcus aureus bacteraemia in two hospitals in Oxfordshire, 1997-2003: cohort study

    David H Wyllie;Derrick W Crook;Tim E A Peto

  • Predictors of First Recurrence of Clostridium difficile Infection: Implications for Initial Management

    David W. Eyre;A. Sarah Walker;David Wyllie;Kate E. Dingle;Kate E. Dingle

  • Relationship Between Bacterial Strain Type, Host Biomarkers, and Mortality in Clostridium difficile Infection

    A. Sarah Walker;David W. Eyre;David H. Wyllie;Kate E. Dingle

  • Characterisation of Clostridium difficile Hospital Ward–Based Transmission Using Extensive Epidemiological Data and Molecular Typing

    A. Sarah Walker;A. Sarah Walker;David W. Eyre;David H. Wyllie;Kate E. Dingle;Kate E. Dingle

  • A lipopolysaccharide-deficient mutant of Neisseria meningitidis elicits attenuated cytokine release by human macrophages and signals via toll-like receptor (TLR) 2 but not via TLR4/MD2.

    Alison C. Pridmore;David H. Wyllie;Fatumo Abdillahi;Liana Steeghs

Frequent Co-Authors

Derrick W. Crook
Derrick W. Crook University of Oxford
Tim E. A. Peto
Tim E. A. Peto University of Oxford
A. Sarah Walker
A. Sarah Walker University of Oxford
Daniel J. Wilson
Daniel J. Wilson University of Oxford
Nicole Stoesser
Nicole Stoesser University of Oxford
Mark H. Wilcox
Mark H. Wilcox University of Leeds
Kate E. Dingle
Kate E. Dingle University of Oxford
Adrian V. S. Hill
Adrian V. S. Hill University of Oxford
Rory Bowden
Rory Bowden Walter and Eliza Hall Institute of Medical Research
David W. Eyre
David W. Eyre University of Oxford

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