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Overview

Simonetta Guarrera is affiliated with the Italian Institute for Genomic Medicine in Italy. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions in Medicine. Their work focuses on subfields including Molecular Biology, Cancer Research, Pulmonary and Respiratory Medicine, Genetics, and Oncology.

The main topics explored in Simonetta Guarrera's research involve:

  • Epigenetics and DNA Methylation
  • Cancer Genomics and Diagnostics
  • HER2/EGFR in Cancer Research
  • MicroRNA in disease regulation
  • Circular RNAs in diseases
  • Plant Water Relations and Carbon Dynamics
  • Occupational and environmental lung diseases

Recent publications by Simonetta Guarrera include:

  • Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation, 2021, Nature Genetics
  • Integrative genomic and transcriptomic analyses illuminate the ontology of HER2-low breast carcinomas, 2022, Genome Medicine
  • Genomic and phenomic insights from an atlas of genetic effects on DNA methylation, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • FOXA1 regulates alternative splicing in prostate cancer, 2022, Cell Reports
  • MicroRNA 146a is associated with diabetic complications in type 1 diabetic patients from the EURODIAB PCS, 2021, Journal of Translational Medicine

Simonetta Guarrera has frequently published in venues such as Genome Medicine, bioRxiv (Cold Spring Harbor Laboratory), Cancers, International Journal of Cancer, and Nature Genetics. Their collaborative work includes frequent co-authors as follows:

  • Giuseppe Matullo
  • Giovanni Cugliari
  • Clara Viberti
  • Caterina Parlato
  • Carlotta Sacerdote

The scientist's research involves integrating genomic and transcriptomic data to better understand complex mechanisms in cancer and other diseases, emphasizing molecular and epigenetic regulation. Topics such as HER2-low breast carcinomas and microRNA roles in disease regulation have been significant parts of their investigative focus.

Best Publications

  • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

    Georg B. Ehret;Georg B. Ehret;Georg B. Ehret;Patricia B. Munroe;Kenneth M. Rice;Murielle Bochud

  • Genome-wide association study identifies eight loci associated with blood pressure

    Christopher Newton-Cheh;Christopher Newton-Cheh;Toby Johnson;Toby Johnson;Vesela Gateva;Martin D. Tobin

  • Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity

    Simone Wahl;Alexander Drong;Benjamin Lehne;Marie Loh;Marie Loh;Marie Loh

  • XRCC1. XRCC3. XPD gene polymorphisms, smoking and (32)P-DNA adducts in a sample of healthy subjects

    Giuseppe Matullo;Domenico Palli;Marco Peluso;Simonetta Guarrera

  • Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

    Cristian Pattaro;Alexander Teumer;Mathias Gorski;Audrey Y. Chu

  • Sequence Variant on 8q24 Confers Susceptibility to Urinary Bladder Cancer

    Lambertus A Kiemeney;Steinunn Thorlacius;Patrick Sulem;Frank Geller

  • A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci

    Nathaniel Rothman;Montserrat Garcia-Closas;Nilanjan Chatterjee;Nuria Malats

  • Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation

    J.L. Min;G. Hemani;E. Hannon;K.F. Dekkers

  • PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study

    Amand F Schmidt;Daniel I Swerdlow;Daniel I Swerdlow;Michael V Holmes;Michael V Holmes;Riyaz S Patel;Riyaz S Patel

  • DNA repair gene polymorphisms, bulky DNA adducts in white blood cells and bladder cancer in a case-control study.

    Giuseppe Matullo;Simonetta Guarrera;Sonia Carturan;Marco Peluso

  • Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

    Gunter Schumann;Lachlan J. Coin;Anbarasu Lourdusamy;Pimphen Charoen;Pimphen Charoen

  • DNA repair polymorphisms and cancer risk in non-smokers in a cohort study.

    G Matullo;AM Dunning;S Guarrera;C Baynes

  • DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

    Symen Ligthart;Carola Marzi;Stella Aslibekyan;Michael M. Mendelson;Michael M. Mendelson;Michael M. Mendelson

  • Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer

    Xifeng Wu;Yuanqing Ye;Lambertus A. Kiemeney;Patrick Sulem

  • Characterization of whole-genome autosomal differences of DNA methylation between men and women

    Paula Singmann;Doron Shem-Tov;Simone Wahl;Harald Grallert

  • A sequence variant at 4p16.3 confers susceptibility to urinary bladder cancer.

    Lambertus A Kiemeney;Patrick Sulem;Soren Besenbacher;Sita H Vermeulen

  • Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1

    Morris J. Bown;Gregory T. Jones;Seamus C. Harrison;Benjamin J. Wright

  • Discovery of methylated circulating DNA biomarkers for comprehensive non-invasive monitoring of treatment response in metastatic colorectal cancer

    Ludovic Barault;Alessio Amatu;Giulia Siravegna;Agostino Ponzetti

  • Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study

    Ervin R. Fox;J. Hunter Young;Yali Li;Albert W. Dreisbach

  • Genomewide Association Study Using a High-Density Single Nucleotide Polymorphism Array and Case-Control Design Identifies a Novel Essential Hypertension Susceptibility Locus in the Promoter Region of Endothelial NO Synthase

    Erika Salvi;Zoltán Kutalik;Nicola Glorioso;Paola Benaglio

Frequent Co-Authors

Giuseppe Matullo
Giuseppe Matullo University of Turin
Paolo Vineis
Paolo Vineis Imperial College London
Carlotta Sacerdote
Carlotta Sacerdote University of Eastern Piedmont Amadeo Avogadro
Silvia Polidoro
Silvia Polidoro Italian institute for Genomic Medicine
Kari Stefansson
Kari Stefansson deCODE Genetics (Iceland)
Salvatore Panico
Salvatore Panico University of Naples Federico II
Unnur Thorsteinsdottir
Unnur Thorsteinsdottir deCODE Genetics (Iceland)
Nicholas J. Wareham
Nicholas J. Wareham University of Cambridge
Vittorio Krogh
Vittorio Krogh Fondazione IRCCS Istituto Nazionale dei Tumori
André G. Uitterlinden
André G. Uitterlinden Erasmus University Rotterdam

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