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Immunology

D-Index
73
Citations
21264
World Ranking
2123
National Ranking
1032

Research.com Recognitions

  • 2013 - AAI Distinguished Service Award, American Association of Immunologists For outstanding service to AAI and the immunology community as member and Chair of the AAI Committee on Public Affairs, 2005-2012

Overview

Derry C. Roopenian is affiliated with The Jackson Laboratory in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology. Specific subfields include Molecular Biology, Immunology, Cell Biology, Rheumatology, and Cancer Research.

Their main research topics involve Systemic Lupus Erythematosus Research, Skin and Cellular Biology Research, T-cell and B-cell Immunology, Immune Cell Function and Interaction, Wnt/β-catenin signaling in development and cancer, Cancer, Hypoxia, and Metabolism, and Monoclonal and Polyclonal Antibodies Research.

Notable recent publications include:

  • An intact C-terminal end of albumin is required for its long half-life in humans, 2020, Communications Biology
  • An engineered human albumin enhances half-life and transmucosal delivery when fused to protein-based biologics, 2020, Science Translational Medicine
  • FcRn is a CD32a coreceptor that determines susceptibility to IgG immune complex-driven autoimmunity, 2020, The Journal of Experimental Medicine
  • Glucose oxidation-dependent survival of activated B cells provides a putative novel therapeutic target for lupus treatment, 2023, iScience
  • Abrogated AID Function Prolongs Survival and Diminishes Renal Pathology in the BXSB Mouse Model of Systemic Lupus Erythematosus, 2020, The Journal of Immunology

Derry C. Roopenian has frequently published in venues such as PLoS ONE, The Journal of Immunology, bioRxiv (Cold Spring Harbor Laboratory), Abstracts, and Communications Biology.

Frequent co-authors include:

  • John J. Wilson
  • Chih-Hao Chang
  • Thomas J. Sproule
  • John D. Sears
  • John P. Sundberg

The scientist received the AAI Distinguished Service Award from the American Association of Immunologists in 2013. This award recognized their service to the AAI and the immunology community as a member and Chair of the AAI Committee on Public Affairs from 2005 to 2012.

Best Publications

  • FcRn: the neonatal Fc receptor comes of age

    Derry C. Roopenian;Shreeram Akilesh

  • Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6

    Katsutoshi Ozaki;Katsutoshi Ozaki;Rosanne Spolski;Rachel Ettinger;Hyoung Fyo Kim

  • Enhanced antibody half-life improves in vivo activity

    Jonathan Zalevsky;Aaron K Chamberlain;Holly M Horton;Sher Karki

  • The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan.

    Chaity Chaudhury;Samina Mehnaz;John M. Robinson;William L. Hayton

  • Human Neonatal Fc Receptor Mediates Transport of IgG into Luminal Secretions for Delivery of Antigens to Mucosal Dendritic Cells

    Masaru Yoshida;Steven M Claypool;Jessica S Wagner;Emiko Mizoguchi

  • The MHC Class I-Like IgG Receptor Controls Perinatal IgG Transport, IgG Homeostasis, and Fate of IgG-Fc-Coupled Drugs

    Derry C. Roopenian;Gregory J. Christianson;Thomas J. Sproule;Aaron C. Brown

  • Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease

    Stefka B. Petkova;Shreeram Akilesh;Thomas J. Sproule;Gregory J. Christianson

  • CD4+ T Cells and the Proinflammatory Cytokines Gamma Interferon and Interleukin-6 Contribute to Alveolar Bone Loss in Mice

    P J Baker;M Dixon;R T Evans;L Dufour

  • Major Histocompatibility Complex Class I-Deficient NOD-B2mnull Mice are Diabetes and Insulitis Resistant

    David V Serreze;Edward H Leiter;Gregory J Christianson;Dale Greiner

  • Oral infection with Porphyromonas gingivalis and induced alveolar bone loss in immunocompetent and severe combined immunodeficient mice.

    P J Baker;R T Evans;D C Roopenian

  • A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice.

    Jason A. Bubier;Thomas J. Sproule;Oded Foreman;Rosanne Spolski

  • Enhanced human CD4+ T cell engraftment in beta2-microglobulin-deficient NOD-scid mice.

    Sherri W. Christianson;Dale L. Greiner;RuthAnn M. Hesselton;Jean H. Leif

  • Neonatal FcR Expression in Bone Marrow-Derived Cells Functions to Protect Serum IgG from Catabolism

    Shreeram Akilesh;Gregory J. Christianson;Derry C. Roopenian;Andrey S. Shaw

  • Dependence of antibody-mediated presentation of antigen on FcRn

    Shuo-Wang Qiao;Kanna Kobayashi;Finn-Eirik Johansen;Ludvig M. Sollid

  • Podocytes use FcRn to clear IgG from the glomerular basement membrane

    Shreeram Akilesh;Tobias B. Huber;Hui Wu;Gary Wang

  • The Molecular and Functional Characterization of a Dominant Minor H Antigen, H60

    Subramaniam Malarkannan;Patty P. Shih;Peter A. Eden;Tiffany Horng

  • Complete FcRn dependence for intravenous Ig therapy in autoimmune skin blistering diseases

    Ning Li;Minglang Zhao;Julio Hilario-Vargas;Phillip Prisayanh

  • Major histocompatibility complex class I-restricted T cells are required for all but the end stages of diabetes development in nonobese diabetic mice and use a prevalent T cell receptor α chain gene rearrangement

    Teresa P. DiLorenzo;Robert T. Graser;Toshiro Ono;Toshiro Ono;Gregory J. Christianson

  • Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria

    Masaru Yoshida;Kanna Kobayashi;Timothy T. Kuo;Lynn Bry

  • Maternal IL-11Ralpha function is required for normal decidua and fetoplacental development in mice.

    Petra Bilinski;Derry Roopenian;Achim Gossler

Frequent Co-Authors

Herbert C. Morse
Herbert C. Morse National Institute of Allergy and Infectious Diseases
Richard S. Blumberg
Richard S. Blumberg Brigham and Women's Hospital
Jan Terje Andersen
Jan Terje Andersen University of Oslo
Inger Sandlie
Inger Sandlie University of Oslo
Charles G. Orosz
Charles G. Orosz The Ohio State University
John P. Sundberg
John P. Sundberg Vanderbilt University
Wayne I. Lencer
Wayne I. Lencer Harvard University
Sebastian Joyce
Sebastian Joyce Vanderbilt University Medical Center
David V. Serreze
David V. Serreze The Jackson Laboratory
Laurence Morel
Laurence Morel The University of Texas Health Science Center at San Antonio

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