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Immunology

D-Index
58
Citations
21910
World Ranking
3459
National Ranking
1605

Overview

Rosanne Spolski is affiliated with the National Institutes of Health in the United States. Their research primarily focuses on immunology, molecular biology, and medicine, with an emphasis on immune cell function and interaction, T-cell and B-cell immunology, and cytokine signaling pathways.

Spolski's work spans several closely related fields of study including immunology and microbiology, biochemistry, genetics and molecular biology, as well as oncology. Their research output includes studies that investigate RNA research and splicing, CAR-T cell therapy, RNA modifications and cancer, and dermatology and skin diseases.

Notable recent publications include:

  • Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8 + T cell stemness and antitumor immunity (2020), published in Proceedings of the National Academy of Sciences
  • An engineered IL-2 partial agonist promotes CD8+ T cell stemness (2021), published in Nature
  • Thymic stromal lymphopoietin limits primary and recall CD8+ T-cell anti-viral responses (2021), published in eLife
  • MicroRNA-30b Is Both Necessary and Sufficient for Interleukin-21 Receptor-Mediated Angiogenesis in Experimental Peripheral Arterial Disease (2021), published in International Journal of Molecular Sciences
  • LIM-domain-only 4 (LMO4) enhances CD8+ T-cell stemness and tumor rejection by boosting IL-21-STAT3 signaling (2024), published in Signal Transduction and Targeted Therapy

Frequent coauthors who have collaborated extensively with Spolski include:

  • Warren J. Leonard
  • Jangsuk Oh
  • Peng Li
  • Chengyu Liu
  • Jian-Xin Lin

Spolski has published repeatedly in prominent scientific journals such as The Journal of Immunology, eLife, Nature Communications, Science Immunology, and bioRxiv (Cold Spring Harbor Laboratory). These venues reflect the consistent focus of their research in immunology and related disciplines.

Best Publications

  • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.

    Liang Zhou;Ivaylo I Ivanov;Rosanne Spolski;Roy Min

  • New insights into the regulation of T cells by |[gamma]|c family cytokines

    Yrina Rochman;Rosanne Spolski;Warren J. Leonard

  • A Critical Role for IL-21 in Regulating Immunoglobulin Production

    Katsutoshi Ozaki;Rosanne Spolski;Carl G. Feng;Chen-Feng Qi

  • Synergy of IL-21 and IL-15 in regulating CD8+ T cell expansion and function.

    Rong Zeng;Rosanne Spolski;Steven E. Finkelstein;Sang Kon Oh

  • Interleukin-21: Basic Biology and Implications for Cancer and Autoimmunity*

    Rosanne Spolski;Warren J. Leonard

  • Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions

    Ayumi Yoshizaki;Tomomitsu Miyagaki;David J. DiLillo;Takashi Matsushita

  • Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6

    Katsutoshi Ozaki;Katsutoshi Ozaki;Rosanne Spolski;Rachel Ettinger;Hyoung Fyo Kim

  • IL-21 Induces Differentiation of Human Naive and Memory B Cells into Antibody-Secreting Plasma Cells

    Rachel Ettinger;Gary P. Sims;Anna-Marie Fairhurst;Rachel Robbins

  • Interleukin-21: a double-edged sword with therapeutic potential

    Rosanne Spolski;Warren J. Leonard

  • Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation

    Warren J. Leonard;Rosanne Spolski

  • A role for TSLP in the development of inflammation in an asthma model.

    Amin Al-Shami;Rosanne Spolski;John Kelly;Andrea Keane-Myers

  • Biology and regulation of IL-2: from molecular mechanisms to human therapy

    Rosanne Spolski;Peng Li;Warren J. Leonard

  • T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells

    Giuseppina Arbore;Erin E. West;Rosanne Spolski;Avril A. B. Robertson

  • IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy.

    Christian S. Hinrichs;Rosanne Spolski;Chrystal M. Paulos;Luca Gattinoni

  • BATF–JUN is critical for IRF4-mediated transcription in T cells

    Peng Li;Rosanne Spolski;Wei Liao;Lu Wang

  • Adoptively transferred effector cells derived from naïve rather than central memory CD8+ T cells mediate superior antitumor immunity

    Christian S. Hinrichs;Zachary A. Borman;Lydie Cassard;Luca Gattinoni

  • The molecular basis of IL-21–mediated proliferation

    Rong Zeng;Rosanne Spolski;Esther Casas;Wei Zhu

  • A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice.

    Jason A. Bubier;Thomas J. Sproule;Oded Foreman;Rosanne Spolski

  • BACH2 regulates CD8 + T cell differentiation by controlling access of AP-1 factors to enhancers

    Rahul Roychoudhuri;David Clever;David Clever;Peng Li;Yoshiyuki Wakabayashi

  • In vivo antitumor activity of interleukin 21 mediated by natural killer cells.

    Gang Wang;Mary Tschoi;Rosanne Spolski;Yanyan Lou;Yanyan Lou

  • A Role for Thymic Stromal Lymphopoietin in CD4+ T Cell Development

    Amin Al-Shami;Rosanne Spolski;John Kelly;Terry Fry

Frequent Co-Authors

Warren J. Leonard
Warren J. Leonard National Institutes of Health
Herbert C. Morse
Herbert C. Morse National Institute of Allergy and Infectious Diseases
Luca Gattinoni
Luca Gattinoni University of Regensburg
David E. Levy
David E. Levy New York University
Nicholas P. Restifo
Nicholas P. Restifo National Institutes of Health
Derry C. Roopenian
Derry C. Roopenian The Jackson Laboratory
Brian L. Kelsall
Brian L. Kelsall National Institute of Allergy and Infectious Diseases
Christopher A. Klebanoff
Christopher A. Klebanoff Memorial Sloan Kettering Cancer Center
Claudia Kemper
Claudia Kemper National Institutes of Health
Douglas C. Palmer
Douglas C. Palmer National Institutes of Health

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Related Online Degrees & Career Pathways

For students interested in Immunology, pursuing related healthcare degrees can broaden career opportunities. Many online programs cater to individuals transitioning into healthcare, such as online RN programs for non nurses. These programs provide a fast track into nursing for those without a prior medical background, complementing immunology expertise with practical patient care skills.

If you’re looking for a quicker entry point, exploring the easiest ABSN programs to get into can be an effective strategy. Accelerated BSN programs are designed for those with a bachelor’s degree in another field and offer a condensed timeline to obtain nursing qualifications, expanding roles within clinical immunology settings.

For career paths focused on foundational nursing skills, considering the easiest LPN programs to get into offers essential training that supports patient monitoring and care under the guidance of RNs and physicians, relevant in immunology departments.

Finally, those aiming for advanced practice roles may find value in exploring nurse practitioner programs with easy admission. These programs enable immunology professionals to engage in direct patient diagnostics, treatment, and research, blending in-depth immunological knowledge with clinical authority.

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