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Biology and Biochemistry

D-Index
69
Citations
38144
World Ranking
7213
National Ranking
26

Overview

Andreas Brech is affiliated with Oslo University Hospital in Norway and has contributed extensively to research primarily within the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Their work spans multiple subfields, including Molecular Biology, Cell Biology, Epidemiology, Physiology, and Immunology.

The main research topics addressed by Andreas Brech encompass:

  • Autophagy in Disease and Therapy
  • Cellular transport and secretion
  • Calcium signaling and nucleotide metabolism
  • Erythrocyte Function and Pathophysiology
  • Microtubule and mitosis dynamics
  • Endoplasmic Reticulum Stress and Disease
  • Extracellular vesicles in disease

Their publication record includes work published predominantly in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Cellular and Molecular Life Sciences
  • The EMBO Journal
  • Journal of Cell Science

Notable recent papers authored by Andreas Brech include:

  • Wetting regulates autophagy of phase-separated compartments and the cytosol, 2021, Nature
  • Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair, 2022, The EMBO Journal
  • Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation, 2020, Nature Cell Biology
  • Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake, 2020, Nature Communications
  • Host autophagy mediates organ wasting and nutrient mobilization for tumor growth, 2021, The EMBO Journal

Frequent co-authors in Andreas Brech's research include:

  • Harald Stenmark
  • Sebastian W. Schultz
  • Camilla Raiborg
  • Eva M. Wenzel
  • Ashish Jain

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • p62/SQSTM1 Binds Directly to Atg8/LC3 to Facilitate Degradation of Ubiquitinated Protein Aggregates by Autophagy

    Serhiy Pankiv;Terje Høyvarde Clausen;Trond Lamark;Andreas Brech

  • p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

    Geir Bjørkøy;Trond Lamark;Andreas Brech;Heidi Outzen

  • EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

    Anne Simonsen;Roger Lippé;Savvas Christoforidis;Jean Michel Gaullier

  • Monitoring autophagic degradation of p62/SQSTM1.

    Geir Bjørkøy;Trond Lamark;Serhiy Pankiv;Aud Øvervatn

  • Multivesicular Endosome Biogenesis in the Absence of ESCRTs

    Susanne Stuffers;Catherine Sem Wegner;Harald Stenmark;Andreas Brech

  • Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila.

    Anne Simonsen;Robert C. Cumming;Robert C. Cumming;Andreas Brech;Pauline Isakson;Pauline Isakson

  • Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease

    Maria Filimonenko;Susanne Stuffers;Camilla Raiborg;Ai Yamamoto

  • The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway

    Yiyu T. Zheng;Shahab Shahnazari;Andreas Brech;Trond Lamark

  • FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end–directed vesicle transport

    Serhiy Pankiv;Endalkachew A. Alemu;Andreas Brech;Jack Ansgar Bruun

  • Endocytic pathways regulate Toll‐like receptor 4 signaling and link innate and adaptive immunity

    Harald Husebye;Øyvind Halaas;Harald Stenmark;Harald Stenmark;Gro Tunheim

  • Hrs regulates multivesicular body formation via ESCRT recruitment to endosomes.

    Kristi G. Bache;Andreas Brech;Anja Mehlum;Harald Alfred Stenmark

  • Programmed Autophagy in the Drosophila Fat Body Is Induced by Ecdysone through Regulation of the PI3K Pathway

    Tor Erik Rusten;Karine Lindmo;Gábor Juhász;Miklós Sass

  • The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy

    Maria Filimonenko;Pauline Isakson;Kim D. Finley;Monique Anderson

  • Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain.

    Ioannis P. Nezis;Anne Simonsen;Antonia P. Sagona;Kim Finley

  • Microenvironmental autophagy promotes tumour growth.

    Nadja S. Katheder;Nadja S. Katheder;Rojyar Khezri;Rojyar Khezri;Fergal O’Farrell;Fergal O’Farrell;Sebastian W. Schultz;Sebastian W. Schultz

  • Repeated ER–endosome contacts promote endosome translocation and neurite outgrowth

    Camilla Raiborg;Eva M. Wenzel;Nina M. Pedersen;Hallvard Olsvik

  • Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

    Marina Vietri;Kay Oliver Schink;Coen Campsteijn;Catherine Sem Wegner

  • ESCRTs and Fab1 Regulate Distinct Steps of Autophagy

    Tor Erik Rusten;Thomas Vaccari;Karine Lindmo;Lina M W Rodahl

  • NBR1 acts as an autophagy receptor for peroxisomes

    Elizabeth Deosaran;Kenneth B. Larsen;Rong Hua;Graeme Sargent

Frequent Co-Authors

Harald Alfred Stenmark
Harald Alfred Stenmark University of Oslo
Terje Johansen
Terje Johansen University of Tromsø - The Arctic University of Norway
Trond Lamark
Trond Lamark University of Tromsø - The Arctic University of Norway
Kirsten Sandvig
Kirsten Sandvig Oslo University Hospital
Trond Berg
Trond Berg University of Oslo
Anne Simonsen
Anne Simonsen University of Oslo
Ragnhild A. Lothe
Ragnhild A. Lothe University of Oslo
Kjetil Taskén
Kjetil Taskén Oslo University Hospital
Sjur Olsnes
Sjur Olsnes University of Oslo
Noboru Mizushima
Noboru Mizushima University of Tokyo

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