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Ragnhild A. Lothe

Ragnhild A. Lothe

D-Index & Metrics

Medicine

D-Index
88
Citations
24867
World Ranking
13285
National Ranking
61

Overview

Ragnhild A. Lothe is affiliated with the University of Oslo in Norway and has contributed extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research involves a focus on oncology, particularly cancer research, pathology, and surgical studies related to cancer treatment and diagnostics.

Their scholarly output encompasses a range of topics primarily centered on cancer genomics and diagnostics, colorectal cancer treatments and studies, and genetic factors in colorectal cancer. Additional areas of focus include prostate cancer treatment and research, hepatocellular carcinoma treatment and prognosis, cancer immunotherapy and biomarkers, and lung cancer treatments and mutations.

Ragnhild A. Lothe has published regularly in several key academic venues, with the most frequent being:

  • Cancer Research
  • Molecular Oncology
  • Journal of Translational Medicine
  • Nature Communications
  • Genome Medicine

Co-authorship collaborations reflect a consistent partnership with several researchers, including:

  • Anita Sveen
  • Arild Nesbakken
  • Ina A. Eilertsen
  • Christian H. Bergsland
  • Rolf I. Skotheim

Among their recent publications are the following works:

  • Patient-Derived Organoids from Multiple Colorectal Cancer Liver Metastases Reveal Moderate Intra-patient Pharmacotranscriptomic Heterogeneity, 2020, Clinical Cancer Research
  • Metastatic heterogeneity of the consensus molecular subtypes of colorectal cancer, 2021, npj Genomic Medicine
  • Identification of 22 susceptibility loci associated with testicular germ cell tumors, 2021, Nature Communications
  • Molecular correlates of sensitivity to PARP inhibition beyond homologous recombination deficiency in pre-clinical models of colorectal cancer point to wild-type TP53 activity, 2020, EBioMedicine
  • High expression of SCHLAP1 in primary prostate cancer is an independent predictor of biochemical recurrence, despite substantial heterogeneity, 2021, Neoplasia

Their work shows a concentration on colorectal cancer, both at the molecular and clinical levels, and extends to investigations into genetic susceptibility and treatment responses across various cancer types. The interplay between genetic factors, tumor heterogeneity, and treatment efficacy is a recurring focus in their published research.

Best Publications

  • Epigenetic and genetic features of 24 colon cancer cell lines.

    D. Ahmed;P. W. Eide;I. A. Eilertsen;S. A. Danielsen

  • Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history.

    Ragnhild A. Lothe;Paivi Peltomaki;Gunn Iren Meling;Lauri A. Aaltonen

  • Microsatellite instability is associated with tumors that characterize the hereditary non-polyposis colorectal carcinoma syndrome.

    P Peltomäki;R A Lothe;L A Aaltonen;L Pylkkänen

  • Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes

    A Sveen;A Sveen;S Kilpinen;A Ruusulehto;R A Lothe;R A Lothe

  • Intradermal ras peptide vaccination with granulocyte‐macrophage colony‐stimulating factor as adjuvant: Clinical and immunological responses in patients with pancreatic adenocarcinoma

    Marianne K. Gjertsen;Trond Buanes;Arne R. Rosseland;Arne Bakka

  • Portrait of the PI3K/AKT pathway in colorectal cancer ☆

    Stine Aske Danielsen;Peter Wold Eide;Arild Nesbakken;Tormod Guren

  • Multi-omics of 34 colorectal cancer cell lines - a resource for biomedical studies

    Kaja C. G. Berg;Kaja C. G. Berg;Peter W. Eide;Peter W. Eide;Ina A. Eilertsen;Ina A. Eilertsen;Bjarne Johannessen;Bjarne Johannessen

  • Somatic POLE proofreading domain mutation, immune response, and prognosis in colorectal cancer: a retrospective, pooled biomarker study

    Enric Domingo;Enric Domingo;Luke Freeman-Mills;Emily Rayner;Mark Glaire

  • CMScaller: an R package for consensus molecular subtyping of colorectal cancer pre-clinical models

    Peter W. Eide;Jarle Bruun;Ragnhild A. Lothe;Anita Sveen

  • Determination of the replication error phenotype in human tumors without the requirement for matching normal DNA by analysis of mononucleotide repeat microsatellites

    Xiao-Ping Zhou;Jean-Marc Hoang;You-Jun Li;Raquel Seruca

  • Biomarker-guided therapy for colorectal cancer: strength in complexity

    Anita Sveen;Scott Kopetz;Ragnhild A. Lothe;Ragnhild A. Lothe

  • Epigenetic inactivation of LKB1 in primary tumors associated with the Peutz-Jeghers syndrome

    Manel Esteller;Egle Avizienyte;Paul G. Corn;Ragnhild A. Lothe

  • Survival meta-analyses for >1800 malignant peripheral nerve sheath tumor patients with and without neurofibromatosis type 1

    Matthias Kolberg;Maren Høland;Trude H. Ågesen;Helge R. Brekke

  • ColoGuideEx: a robust gene classifier specific for stage II colorectal cancer prognosis

    Trude H. Ågesen;Anita Sveen;Marianne A. Merok;Guro E. Lind;Guro E. Lind

  • Oncogenicity of the Developmental Transcription Factor Sox9

    Ander Matheu;Manuel Collado;Clare Wise;Lorea Manterola

  • Cisplatin-Induced Long-Term Hearing Impairment Is Associated With Specific Glutathione S-Transferase Genotypes in Testicular Cancer Survivors

    Jan Oldenburg;Sigrid Marie Kraggerud;Milada Cvancarova;Ragnhild Lothe

  • Autophagy in tumour suppression and promotion

    Andreas Brech;Andreas Brech;Terje Cruickshank Ahlquist;Terje Cruickshank Ahlquist;Ragnhild Lothe;Ragnhild Lothe;Harald Alfred Stenmark;Harald Alfred Stenmark

  • A CpG island hypermethylation profile of primary colorectal carcinomas and colon cancer cell lines

    Guro Elisabeth Lind;Lin Thorstensen;Tone Løvig;Gunn I. Meling

  • Different genetic pathways to proximal and distal colorectal cancer influenced by sex-related factors.

    Jarle Breivik;Ragnhild A. Lothe;Gunn Iren Meling;Torleiv O. Rognum

  • Distinct high resolution genome profiles of early onset and late onset colorectal cancer integrated with gene expression data identify candidate susceptibility loci.

    Marianne Berg;Marianne Berg;Trude H. Ågesen;Trude H. Ågesen;Espen Thiis-Evensen;Marianne A. Merok

Frequent Co-Authors

Rolf Inge Skotheim
Rolf Inge Skotheim Oslo University Hospital
Manuel R. Teixeira
Manuel R. Teixeira University of Porto
Sverre Heim
Sverre Heim Oslo University Hospital
Sophie D. Fosså
Sophie D. Fosså Oslo University Hospital
Ola Myklebost
Ola Myklebost University of Bergen
Olli Kallioniemi
Olli Kallioniemi Karolinska Institute
Carmen Jerónimo
Carmen Jerónimo University of Porto
Rui Henrique
Rui Henrique University of Porto
Fredrik Mertens
Fredrik Mertens Lund University
Jahn M. Nesland
Jahn M. Nesland Oslo University Hospital

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