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Biology and Biochemistry

D-Index
56
Citations
12847
World Ranking
14313
National Ranking
1014

Research.com Recognitions

  • 2008 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Physiology and Pharmacology/Toxicology

Overview

Jens Rettig is affiliated with Saarland University in Germany and has contributed to various fields related to immunology and molecular biology.

The main fields of study in Rettig's research include:

  • Immunology and Microbiology
  • Biochemistry, Genetics and Molecular Biology

Subfields of particular focus within these areas are:

  • Immunology
  • Molecular Biology
  • Physiology
  • Cell Biology
  • Oncology

Rettig's research addresses several major topics, including:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Immunotherapy and Immune Responses
  • Cellular transport and secretion
  • Calcium signaling and nucleotide metabolism
  • CAR-T cell therapy research
  • Alzheimer's disease research and treatments

Selected recent papers authored or coauthored by Rettig include:

  • Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes, 2022, Nature Communications
  • Studying the biology of cytotoxic T lymphocytes in vivo with a fluorescent granzyme B-mTFP knock-in mouse, 2020, eLife
  • Cytotoxic Granule Trafficking and Fusion in Synaptotagmin7-Deficient Cytotoxic T Lymphocytes, 2020, Frontiers in Immunology
  • Various Stages of Immune Synapse Formation Are Differently Dependent on the Strength of the TCR Stimulus, 2020, International Journal of Molecular Sciences
  • P38α-MAPK phosphorylates Snapin and reduces Snapin-mediated BACE1 transportation in APP-transgenic mice, 2021, The FASEB Journal

Frequent co-authors listed alongside Rettig are:

  • Hsin-Fang Chang
  • Elmar Krause
  • Claudia Schirra
  • Ute Becherer
  • Keerthana Ravichandran

Rettig's work is often published in venues such as:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • International Journal of Molecular Sciences
  • Frontiers in Immunology
  • The Journal of Immunology
  • Cellular and Molecular Life Sciences

In 2008, Rettig was awarded membership in the German National Academy of Sciences Leopoldina, specifically in the section for Physiology and Pharmacology/Toxicology.

Best Publications

  • Inactivation properties of voltage-gated K+ channels altered by presence of beta-subunit.

    Rettig J;Heinemann Sh;Wunder F;Lorra C

  • Identification of a syntaxin-binding site on N-type calcium channels.

    Zu Hang Sheng;Jens Rettig;Masami Takahashi;William A. Catterall

  • Munc13-1 Is a Presynaptic Phorbol Ester Receptor that Enhances Neurotransmitter Release

    Andrea Betz;Uri Ashery;Michael Rickmann;Iris Augustin

  • Munc18-1 promotes large dense-core vesicle docking.

    Thomas Voets;Ruud F. Toonen;Elisabeth C. Brian;Heidi de Wit

  • Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming.

    Andrea Betz;Pratima Thakur;Harald J. Junge;Uri Ashery

  • Calcium-dependent interaction of N-type calcium channels with the synaptic core complex

    Zu-Hang Sheng;Jens Rettig;Terry Cook;William A. Catterall

  • Emerging roles of presynaptic proteins in Ca++-triggered exocytosis.

    Jens Rettig;Erwin Neher

  • Isoform-specific interaction of the alpha1A subunits of brain Ca2+ channels with the presynaptic proteins syntaxin and SNAP-25.

    J Rettig;Z H Sheng;D K Kim;C D Hodson

  • T cell activation requires mitochondrial translocation to the immunological synapse

    Ariel Quintana;Christian Schwindling;Anna S. Wenning;Ute Becherer

  • Regulation of transmitter release by Unc-13 and its homologues

    Nils Brose;Christian Rosenmund;Jens Rettig

  • Munc13-1 acts as a priming factor for large dense-core vesicles in bovine chromaffin cells.

    Uri Ashery;Frederique Varoqueaux;Thomas Voets;Andrea Betz

  • Functional characterization of Kv channel beta-subunits from rat brain

    S H Heinemann;J Rettig;H R Graack;O Pongs

  • Regulation of Releasable Vesicle Pool Sizes by Protein Kinase A-Dependent Phosphorylation of SNAP-25

    Gábor Nagy;Kerstin Reim;Ulf Matti;Nils Brose

  • A Trimeric Protein Complex Functions as a Synaptic Chaperone Machine

    Sönke Tobaben;Pratima Thakur;Pratima Thakur;Rafael Fernández-Chacón;Thomas C. Südhof

  • v-SNAREs control exocytosis of vesicles from priming to fusion

    Maria Borisovska;Ying Zhao;Yaroslav Tsytsyura;Nataliya Glyvuk

  • Primary structure of a beta subunit of alpha-dendrotoxin-sensitive K+ channels from bovine brain.

    V. E. S. Scott;J. Rettig;D. N. Parcej;J. N. Keen

  • Characterization of a Shaw-related potassium channel family in rat brain.

    J Rettig;F Wunder;M Stocker;R Lichtinghagen

  • Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate local calcium signals for efficient T‐cell activation

    Ariel Quintana;Mathias Pasche;Christian Junker;Dalia Al-Ansary

  • Protein kinase C-dependent phosphorylation of synaptosome-associated protein of 25 kDa at Ser187 potentiates vesicle recruitment.

    Gábor Nagy;Ulf Matti;Ralf B. Nehring;Thomas Binz

  • Phosphorylation of Snapin by PKA modulates its interaction with the SNARE complex.

    Milan G. Chheda;Uri Ashery;Pratima Thakur;Jens Rettig;Jens Rettig

Frequent Co-Authors

Markus Hoth
Markus Hoth Saarland University
Frank Müller
Frank Müller Forschungszentrum Jülich
Rainer Deutzmann
Rainer Deutzmann University of Regensburg
Nils Brose
Nils Brose Max Planck Society
Olaf Pongs
Olaf Pongs Universität Hamburg
Christian Rosenmund
Christian Rosenmund Charité - University Medicine Berlin
William A. Catterall
William A. Catterall University of Washington
Thomas C. Südhof
Thomas C. Südhof Stanford University
Thomas Voets
Thomas Voets KU Leuven
Yenan T. Bryceson
Yenan T. Bryceson Karolinska Institute

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