World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
10797
World Ranking
13308
National Ranking
455

Overview

Kris Chadee is affiliated with the University of Calgary in Canada. Their research output spans multiple fields with a focus on medicine, biochemistry, genetics, and molecular biology. The scientist's work addresses several subfields including molecular biology, surgery, infectious diseases, parasitology, and immunology.

Their research covers diverse topics as reflected in their main areas of work:

  • Amoebic Infections and Treatments
  • Glycosylation and Glycoproteins Research
  • Gut microbiota and health
  • Parasitic Infections and Diagnostics
  • Helicobacter pylori-related gastroenterology studies
  • Pancreatitis Pathology and Treatment
  • Galectins and Cancer Biology

Chadee has published extensively in a number of scientific journals. Frequently publishing venues include:

  • Journal of the Canadian Association of Gastroenterology
  • The FASEB Journal
  • Gastroenterology
  • Frontiers in Immunology
  • PLoS Pathogens

Collaborations form an important aspect of their work, with frequent coauthors being:

  • France Moreau
  • Hayley Gorman
  • Antoine Dufour
  • Christina Amat
  • André G. Buret

Some of Chadee's recent papers include the following:

  • "Unfermented β-fructan Fibers Fuel Inflammation in Select Inflammatory Bowel Disease Patients," 2022, Gastroenterology
  • "Increased intestinal permeability exacerbates sepsis through reduced hepatic SCD-1 activity and dysregulated iron recycling," 2020, Nature Communications
  • "Muc2 Mucin and Nonmucin Microbiota Confer Distinct Innate Host Defense in Disease Susceptibility and Colonic Injury," 2020, Cellular and Molecular Gastroenterology and Hepatology
  • "Autophagy is required during high MUC2 mucin biosynthesis in colonic goblet cells to contend metabolic stress," 2021, American Journal of Physiology-Gastrointestinal and Liver Physiology
  • "IgGFc-binding protein and MUC2 mucin produced by colonic goblet-like cells spatially interact non-covalently and regulate wound healing," 2023, Frontiers in Immunology

Best Publications

  • Muc2 Protects against Lethal Infectious Colitis by Disassociating Pathogenic and Commensal Bacteria from the Colonic Mucosa

    Kirk S. B. Bergstrom;Vanessa Kissoon-Singh;Deanna L. Gibson;Caixia Ma

  • The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells.

    C. Caballero-Franco;K. Keller;C. De Simone;K. Chadee

  • Roles and regulation of the mucus barrier in the gut.

    Steve Cornick;Adelaide Tawiah;Kris Chadee

  • Role of Intestinal Mucins in Innate Host Defense Mechanisms against Pathogens

    Poonam Dharmani;Vikas Srivastava;Vanessa Kissoon-Singh;Kris Chadee

  • Prostaglandin E2 receptor distribution and function in the gastrointestinal tract

    I Dey;M Lejeune;K Chadee

  • PPARγ is an E3 ligase that induces the degradation of NFκB/p65

    Yongzhong Hou;Kris Chadee

  • Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel

    Martin E. Lidell;Darcy M. Moncada;Kris Chadee;Gunnar C. Hansson

  • NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations

    Leanne Mortimer;Justin A MacDonald;Kris Chadee

  • The immunopathogenesis of Entamoeba histolytica.

    Leanne Mortimer;Kris Chadee

  • Fusobacterium nucleatum Infection of Colonic Cells Stimulates MUC2 Mucin and Tumor Necrosis Factor Alpha

    Poonam Dharmani;Jaclyn Strauss;Christian Ambrose;Emma Allen-Vercoe

  • Fusobacterium nucleatum: an emerging gut pathogen?

    Emma Allen-Vercoe;Jaclyn Strauss;Kris Chadee

  • Entamoeba histolytica Cysteine Proteinase 5 Binds Integrin on Colonic Cells and Stimulates NFκB-mediated Pro-inflammatory Responses

    Yongzhong Hou;Leanne Mortimer;Kris Chadee

  • Tumor Necrosis Factor-α and Muc2 Mucin Play Major Roles in Disease Onset and Progression in Dextran Sodium Sulphate-Induced Colitis

    Poonam Dharmani;Pearl Leung;Kris Chadee

  • Suppression of NF-κB Activation by Entamoeba histolytica in Intestinal Epithelial Cells Is Mediated by Heat Shock Protein 27

    Srinivas J. Kammanadiminti;Kris Chadee

  • Hypoxia-Inducible Factor Signaling Provides Protection in Clostridium difficile-Induced Intestinal Injury

    Simon A. Hirota;Kyla Fines;Jeffrey Ng;Danya Traboulsi

  • The NLRP3 Inflammasome Is a Pathogen Sensor for Invasive Entamoeba histolytica via Activation of α5β1 Integrin at the Macrophage-Amebae Intercellular Junction

    Leanne Mortimer;Steve Cornick;Kris Chadee

  • Entamoeba histolytica Exacerbates Epithelial Tight Junction Permeability and Proinflammatory Responses in Muc2−/− Mice

    Vanessa Kissoon-Singh;Elizabeth Trusevych;Kris Chadee

  • Colonic MUC2 mucin regulates the expression and antimicrobial activity of β-defensin 2.

    E R Cobo;Kissoon-Singh;F Moreau;K Chadee

  • Probiotic mixture VSL#3 reduces colonic inflammation and improves intestinal barrier function in Muc2 mucin-deficient mice.

    Manish Kumar;Vanessa Kissoon-Singh;Aralia Leon Coria

  • The probiotic mixture VSL#3 accelerates gastric ulcer healing by stimulating vascular endothelial growth factor.

    Poonam Dharmani;Claudio De Simone;Kris Chadee

Frequent Co-Authors

Andre G. Buret
Andre G. Buret University of Calgary
Morley D. Hollenberg
Morley D. Hollenberg University of Calgary
Paul L. Beck
Paul L. Beck University of Calgary
Michael G. Surette
Michael G. Surette McMaster University
Herbert Y. Gaisano
Herbert Y. Gaisano University of Toronto
Emma Allen-Vercoe
Emma Allen-Vercoe University of Guelph
Andre J. Ouellette
Andre J. Ouellette University of Southern California
Mark A. Giembycz
Mark A. Giembycz University of Calgary
Bruce A. Vallance
Bruce A. Vallance University of British Columbia
B. Brett Finlay
B. Brett Finlay University of British Columbia

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