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Biology and Biochemistry

D-Index
65
Citations
16103
World Ranking
9101
National Ranking
4043

Overview

Andre J. Ouellette is affiliated with the University of Southern California in the United States. Their research primarily focuses on immunology and microbiology, with notable involvement in biochemistry, genetics, and molecular biology.

Their work spans several subfields, including molecular biology, microbiology, immunology, oncology, and genetics. Key topics in their research cover antimicrobial peptides and activities, immune response and inflammation, biochemical and structural characterization, gut microbiota and health, probiotics and fermented foods, Wnt/β-catenin signaling in development and cancer, and cancer-related molecular pathways.

Ouellette's recent published papers reflect the breadth of their research interests. These include:

  • p300 Serine 89: A Critical Signaling Integrator and Its Effects on Intestinal Homeostasis and Repair, 2021, published in Cancers
  • Decreased Paneth cell α-defensins promote fibrosis in a choline-deficient L-amino acid-defined high-fat diet-induced mouse model of nonalcoholic steatohepatitis via disrupting intestinal microbiota, 2023, Scientific Reports
  • Host Defense Peptides as Templates for Antifungal Drug Development, 2020, Journal of Fungi
  • PTPN2 Is a Critical Regulator of Ileal Paneth Cell Viability and Function in Mice, 2023, Cellular and Molecular Gastroenterology and Hepatology
  • A host-directed macrocyclic peptide therapeutic for MDR gram negative bacterial infections, 2021, Scientific Reports

Frequent coauthors in their research include Michael E. Selsted, Katie Trinh, Yoshihiro Eriguchi, Dat Q. Tran, and Prasad Tongaonkar. These collaborations reflect a network of ongoing scientific partnerships contributing to their research output.

Ouellette's most frequent venues for publication include Scientific Reports, Cancers, Journal of Fungi, Cellular and Molecular Gastroenterology and Hepatology, and Mediators of Inflammation. These journals indicate a focus on both clinical and molecular aspects of immunological and microbiological research.

Best Publications

  • Mammalian Defensins in the Antimicrobial Immune Response

    Michael E. Selsted;André J. Ouellette

  • Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria.

    Tokiyoshi Ayabe;Donald P. Satchell;Carole L. Wilson;William C. Parks

  • Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

    Carole L. Wilson;Andre J. Ouellette;Donald P. Satchell;Tokiyoshi Ayabe

  • A Cyclic Antimicrobial Peptide Produced in Primate Leukocytes by the Ligation of Two Truncated α-Defensins

    Yi-Quan Tang;Jun Yuan;George Ösapay;Klara Ösapay

  • Type beta transforming growth factor reversibly inhibits the early proliferative response to partial hepatectomy in the rat

    William E. Russell;Robert J. Coffey;Andre J. Ouellette;Harold L. Moses

  • Enteric defensins: antibiotic peptide components of intestinal host defense.

    M E Selsted;S I Miller;A H Henschen;A J Ouellette

  • Paneth cell defensins: endogenous peptide components of intestinal host defense.

    Andre J. Ouellette;Michael E. Selsted

  • Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium.

    A J Ouellette;R M Greco;M James;D Frederick

  • Paneth cell differentiation in the developing intestine of normal and transgenic mice

    Lynn Bry;Per Falk;Kenneth Huttner;Andre Ouellette

  • Mouse Paneth cell defensins: primary structures and antibacterial activities of numerous cryptdin isoforms.

    A J Ouellette;M M Hsieh;M T Nosek;D F Cano-Gauci

  • Activation of Paneth Cell α-Defensins in Mouse Small Intestine

    Tokiyoshi Ayabe;Donald P. Satchell;Patrizia Pesendorfer;Hiroki Tanabe

  • Paneth cells and innate immunity in the crypt microenvironment

    Andre J. Ouellette

  • Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2−/− mice

    Fang Zhao;Robert Edwards;Diana Dizon;Kambiz Afrasiabi

  • Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization.

    Nathan W. Schmidt;Abhijit Mishra;Ghee Hwee Lai;Matthew Davis

  • Paneth cells and innate mucosal immunity.

    André J Ouellette

  • Paneth cell defensins and innate immunity of the small bowel.

    Andre J. Ouellette;Charles L. Bevins

  • Defensins in granules of phagocytic and non-phagocytic cells

    Michael E. Selsted;Andre J. Ouellette

  • Paneth cell α-defensins in enteric innate immunity

    André Joseph Ouellette

  • Expression of two "immediate early" genes, Egr-1 and c-fos, in response to renal ischemia and during compensatory renal hypertrophy in mice.

    A J Ouellette;R A Malt;V P Sukhatme;J V Bonventre

  • A novel mouse gene family coding for cationic, cysteine-rich peptides. Regulation in small intestine and cells of myeloid origin.

    A J Ouellette;J C Lualdi

Frequent Co-Authors

Michael E. Selsted
Michael E. Selsted University of Southern California
Victor J. Dzau
Victor J. Dzau Duke University
Raz Jelinek
Raz Jelinek Ben-Gurion University of the Negev
Wuyuan Lu
Wuyuan Lu University of Maryland, Baltimore
Wayne I. Lencer
Wayne I. Lencer Harvard University
James L. Madara
James L. Madara American Medical Association
William C. Parks
William C. Parks Cedars-Sinai Medical Center
K. Johan Rosengren
K. Johan Rosengren University of Queensland
Joseph V. Bonventre
Joseph V. Bonventre Brigham and Women's Hospital
David J. Craik
David J. Craik University of Queensland

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