Edward G. D. Tuddenham

Overview

Best Publications

• Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B

  Amit C. Nathwani;Edward G.D. Tuddenham;Savita Rangarajan;Cecilia Rosales

  2195
  Citations

• Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2

  Simone Rost;Andreas Fregin;Vytautas Ivaskevicius;Ernst Conzelmann

  1483
  Citations

• Long-term safety and efficacy of factor IX gene therapy in hemophilia B

  Amit C Nathwani;Ulreke M Reiss;Edward G D Tuddenham;Cecilia Rosales;Cecilia Rosales

  1397
  Citations

• The hemophilias--from royal genes to gene therapy.

  Pier M. Mannucci;Edward G.D. Tuddenham

  1311
  Citations

• Structure of human factor VIII.

  Gordon A. Vehar;Bruce Keyt;Dan Eaton;Henry Rodriguez

  1180
  Citations

• Expression of active human factor VIII from recombinant DNA clones

  William I. Wood;Daniel J. Capon;Christian C. Simonsen;Dan L. Eaton

  920
  Citations

• Biopsy of human preimplantation embryos and sexing by DNA amplification.

  A.H. Handyside;R.J.A. Penketh;R.M.L. Winston;J.K. Pattinson

  677
  Citations

• Self-complementary adeno-associated virus vectors containing a novel liver-specific human factor IX expression cassette enable highly efficient transduction of murine and nonhuman primate liver

  Amit C. Nathwani;John T. Gray;Catherine Y. C. Ng;Junfang Zhou

  443
  Citations

• Haemophilia A: mutation type determines risk of inhibitor formation.

  Rainer Schwaab;H.-H. Brackmann;C. Meyer;J. Seehafer

  430
  Citations

• Distribution of factor VIII mRNA and antigen in human liver and other tissues

  Karen L. Wion;Deirdre Kelly;John A. Summerfield;Edward G. D. Tuddenham

  379
  Citations

• Bleeding due to disruption of a cargo-specific ER-to-Golgi transport complex.

  Bin Zhang;Michael A. Cunningham;William C. Nichols;John A. Bernat

  334
  Citations

• Genetic mapping and diagnosis of haemophilia A achieved through a BclI polymorphism in the factor VIII gene

  Jane Gitschier;Dennis Drayna;Edward G. D. Tuddenham;Ray L. White

  313
  Citations

• Noninvasive prenatal diagnosis of hemophilia by microfluidics digital PCR analysis of maternal plasma DNA.

  Nancy B. Y. Tsui;Rezan A. Kadir;K. C. Allen Chan;Claudia Chi

  305
  Citations

• Crystal structure of the extracellular region of human tissue factor

  K. Harlos;D. M. A. Martin;D. P. O'Brien;E. Y. Jones

  304
  Citations

• High prevalence of elevated factor VIII levels in patients referred for thrombophilia screening: role of increased synthesis and relationship to the acute phase reaction.

  J O’Donnell;E G D Tuddenham;R Manning;G Kemball-Cook

  304
  Citations

• Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant.

  Jenny McIntosh;Jenny McIntosh;Peter J. Lenting;Cecilia Rosales;Cecilia Rosales;Doyoung Lee

  302
  Citations

• A gene for hereditary haemorrhagic telangiectasia maps to chromosome 9q3.

  Claire L. Shovlin;J.M.B. Hughes;E.G.D. Tuddenham;I. Temperley

  288
  Citations

• The factor VIII Structure and Mutation Resource Site: HAMSTeRS version 4.

  Geoffrey Kemball-Cook;Edward G. D. Tuddenham;Adam I. Wacey

  286
  Citations

• Safe and efficient transduction of the liver after peripheral vein infusion of self-complementary AAV vector results in stable therapeutic expression of human FIX in nonhuman primates

  Amit C. Nathwani;John T. Gray;Jenny McIntosh;Catherine Y. C. Ng

  283
  Citations

• A Molecular Model for the Triplicated A Domains of Human Factor VIII Based on the Crystal Structure of Human Ceruloplasmin

  S. Pemberton;S. Pemberton;P. Lindley;P. Lindley;V. Zaitsev;V. Zaitsev;G. Card;G. Card

  261
  Citations