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Chemistry

D-Index
44
Citations
32585
World Ranking
16628
National Ranking
4125

Overview

Lalith Perera is affiliated with the National Institutes of Health in the United States. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with 77 publications, as well as Medicine, contributing 48 publications. Within these fields, their subfield specializations include Molecular Biology, Infectious Diseases, Cell Biology, Spectroscopy, and Organic Chemistry.

The scientist's main research topics include:

  • RNA and protein synthesis mechanisms
  • RNA Research and Splicing
  • RNA modifications and cancer
  • DNA and Nucleic Acid Chemistry
  • Glycosylation and Glycoproteins Research
  • DNA Repair Mechanisms
  • Viral gastroenteritis research and epidemiology

Lalith Perera has contributed to numerous publications across various venues. The most frequent publication venues include UNC Libraries, bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Nucleic Acids Research, and Nature Structural & Molecular Biology.

Their recent published papers include:

  • Potential SARS-CoV-2 main protease inhibitors (2020) in Drug Discovery Today
  • Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics (2021) in Nature Communications
  • Characterization of SARS2 Nsp15 nuclease activity reveals it's mad about U (2021) in Nucleic Acids Research
  • Tunable Cysteine-Targeting Electrophilic Heteroaromatic Warheads Induce Ferroptosis (2022) in Journal of Medicinal Chemistry
  • Structural basis for pre-tRNA recognition and processing by the human tRNA splicing endonuclease complex (2023) in Nature Structural & Molecular Biology

Frequent collaborators in their research include Lee G. Pedersen, J.M. Krahn, Mario J. Borgnia, Jason G. Williams, and Zachary D. Stewart. Each has coauthored between 9 and 18 publications alongside Lalith Perera.

Best Publications

  • A smooth particle mesh Ewald method

    Ulrich Essmann;Lalith Perera;Max L. Berkowitz;Tom Darden

  • New tricks for modelers from the crystallography toolkit: the particle mesh Ewald algorithm and its use in nucleic acid simulations.

    Tom Darden;Lalith Perera;Leping Li;Lee Pedersen

  • Molecular dynamics simulation of sodium dodecyl sulfate micelle in water: Micellar structural characteristics and counterion distribution

    Chrystal D. Bruce;Max L Berkowitz;Lalith Perera;Malcolm D D. E. Forbes

  • Many-body effects in molecular dynamics simulations of Na +(H2O)n and Cl-(H2O) n clusters

    Lalith Perera;Max L. Berkowitz

  • Towards accurate solvation dynamics of divalent cations in water using the polarizable amoeba force field: From energetics to structure.

    Jean Philip Piquemal;Lalith Perera;G. Andrés Cisneros;Pengyu Ren

  • Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling.

    Shingo Mutoh;Mack Sobhany;Rick Moore;Lalith Perera

  • Molecular dynamics simulations of sodium dodecyl sulfate micelle in water: The behavior of water

    Chrystal D. Bruce;Sanjib Senapati;Max L. Berkowitz;Lalith Perera

  • Structures of Cl-(H2O)n and F -(H2O)n (n=2,3,..., 15) clusters. Molecular dynamics computer simulations

    Lalith Perera;Max L. Berkowitz

  • Effect of the treatment of long‐range forces on the dynamics of ions in aqueous solutions

    Lalith Perera;Ulrich Essmann;Max L. Berkowitz

  • Structure and dynamics of Cl−(H2O)20 clusters: The effect of the polarizability and the charge of the ion

    Lalith Perera;Max L. Berkowitz

  • Potential SARS-CoV-2 main protease inhibitors.

    Riddhidev Banerjee;Lalith Perera;L.M. Viranga Tillekeratne

  • The origin of the hydration interaction of lipid bilayers from MD simulation of dipalmitoylphosphatidylcholine membranes in gel and liquid crystalline phases

    Ulrich Essmann;Lalith Perera;Max L. Berkowitz

  • Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

    Bret D. Freudenthal;William A. Beard;Lalith E. Perera;David D. Shock

  • Dephosphorylation of Threonine 38 Is Required for Nuclear Translocation and Activation of Human Xenobiotic Receptor CAR (NR1I3)

    Shingo Mutoh;Makoto Osabe;Kaoru Inoue;Rick Moore

  • Stabilization energies of Cl−, Br−, and I− ions in water clusters

    Lalith Perera;Max L. Berkowitz

  • Dynamics of ion solvation in a Stockmayer fluid

    Lalith Perera;Max L. Berkowitz

  • Characterization of Estrogenic and Androgenic Activities for Bisphenol A-like Chemicals (BPs): In Vitro Estrogen and Androgen Receptors Transcriptional Activation, Gene Regulation, and Binding Profiles.

    Katherine E Pelch;Yin Li;Lalith Perera;Kristina A Thayer

  • The solvation of Cl-, Br-, and I- in acetonitrile clusters: Photoelectron spectroscopy and molecular dynamics simulations

    Gil Markovich;Lalith Perera;Max L. Berkowitz;Ori Cheshnovsky

  • Erratum: Many‐body effects in molecular dynamics simulations of Na+(H2O)n and Cl−(H2O)n clusters [J. Chem. Phys. 95, 1954 (1991)]

    Lalith Perera;Max L. Berkowitz

  • Spectral shifts and structural classes in microsolutions of rare gas clusters containing a molecular chromophore

    Lalith Perera;François G. Amar

  • Structure and Dynamics of Zymogen Human Blood Coagulation Factor X

    Divi Venkateswarlu;Lalith Perera;Tom Darden;Lee G. Pedersen;Lee G. Pedersen

  • Surface solvation for an ion in a water cluster

    David H. Herce;Lalith Perera;Thomas A. Darden;Celeste Sagui

  • Cryo-EM structures of the SARS-CoV-2 endoribonuclease Nsp15 reveal insight into nuclease specificity and dynamics.

    Monica C. Pillon;Monica C. Pillon;Meredith N. Frazier;Lucas B. Dillard;Jason G. Williams

Frequent Co-Authors

Lee G. Pedersen
Lee G. Pedersen University of North Carolina at Chapel Hill
Max L. Berkowitz
Max L. Berkowitz University of North Carolina at Chapel Hill
Lars C. Pedersen
Lars C. Pedersen National Institutes of Health
Perry J. Blackshear
Perry J. Blackshear National Institutes of Health
Robert E. London
Robert E. London National Institutes of Health
Samuel H. Wilson
Samuel H. Wilson National Institutes of Health
William A. Beard
William A. Beard National Institutes of Health
Masahiko Negishi
Masahiko Negishi National Institutes of Health
Paul A. Wade
Paul A. Wade National Institutes of Health
Thomas A. Kunkel
Thomas A. Kunkel National Institutes of Health

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