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Hiroshi Okamoto

Hiroshi Okamoto

D-Index & Metrics

Biology and Biochemistry

D-Index
66
Citations
13654
World Ranking
8795
National Ranking
595

Overview

Hiroshi Okamoto is affiliated with Kanazawa University in Japan and has contributed extensively to the field of medicine, focusing particularly on surgery and related sub-disciplines.

Their research spans multiple areas within medical science, including pulmonary and respiratory medicine, physiology, gastroenterology, and oncology. Specific topics of study include esophageal and gastrointestinal pathology, esophageal cancer research and treatment, gastroesophageal reflux and treatments, metastasis and carcinoma case studies, tracheal and airway disorders, dysphagia assessment and management, as well as calcium signaling and nucleotide metabolism.

Hiroshi Okamoto has published in various notable venues, with frequent publications appearing in:

  • Diseases of the Esophagus
  • Cancers
  • Annals of Gastroenterological Surgery
  • Journal of Clinical Medicine
  • Surgical Case Reports

Their recent notable papers include:

  • "Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD+" (2021, Journal of Neurochemistry)
  • "GR, Sgk1, and NDRG1 in esophageal squamous cell carcinoma: their correlation with therapeutic outcome of neoadjuvant chemotherapy" (2020, BMC Cancer)
  • "The pivotal role of the angiotensin-II-NF-κB axis in the development of COVID-19 pathophysiology" (2020, Hypertension Research)
  • "Necroptosis in Esophageal Squamous Cell Carcinoma: An Independent Prognostic Factor and Its Correlation with Tumor-Infiltrating Lymphocytes" (2021, Cancers)
  • "Oxytocin and CD38 in the paraventricular nucleus play a critical role in paternal aggression in mice" (2020, Hormones and Behavior)

The scientist has collaborated frequently with several coauthors, including:

  • Yusuke Taniyama
  • Chiaki Sato
  • Takashi Kamei
  • Yohei Ozawa
  • Hirotaka Ishida

Best Publications

  • Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury.

    Hideto Yonekura;Yasuhiko Yamamoto;Shigeru Sakurai;Ralica G. Petrova

  • CD38 is critical for social behaviour by regulating oxytocin secretion

    Duo Jin;Hong Xiang Liu;Hirokazu Hirai;Takashi Torashima

  • Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice

    Yasuhiko Yamamoto;Ichiro Kato;Toshio Doi;Hideto Yonekura

  • Cyclic ADP-ribose in insulin secretion from pancreatic beta cells

    Shin Takasawa;Koji Nata;Hideto Yonekura;Hiroshi Okamoto

  • Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP.

    S Takasawa;A Tohgo;N Noguchi;T Koguma

  • RAGE control of diabetic nephropathy in a mouse model: effects of RAGE gene disruption and administration of low-molecular weight heparin.

    Khin Mar Myint;Yasuhiko Yamamoto;Toshio Doi;Ichiro Kato

  • The Reg gene family and Reg proteins: with special attention to the regeneration of pancreatic β-cells

    Hiroshi Okamoto

  • CD38 DISRUPTION IMPAIRS GLUCOSE-INDUCED INCREASES IN CYCLIC ADP-RIBOSE, CA2+I, AND INSULIN SECRETION

    Ichiro Kato;Yasuhiko Yamamoto;Miki Fujimura;Naoya Noguchi

  • Activation of Reg gene, a gene for insulin-producing β-cell regeneration: Poly(ADP-ribose) polymerase binds Reg promoter and regulates the transcription by autopoly(ADP-ribosyl)ation

    Takako Akiyama;Shin Takasawa;Koji Nata;Seiichi Kobayashi

  • ADP ribosyl cyclase activity of a novel bone marrow stromal cell surface molecule, BST-1

    Yuichi Hirata;Naoki Kimura;Koh Sato;Yoshiyuki Ohsugi

  • Identification of a Receptor for Reg (Regenerating Gene) Protein, a Pancreatic β-Cell Regeneration Factor

    Seiichi Kobayashi;Takako Akiyama;Koji Nata;Michiaki Abe

  • Transgenic Mice Overexpressing Type 2 Nitric-oxide Synthase in Pancreatic β Cells Develop Insulin-dependent Diabetes without Insulitis

    Toshinari Takamura;Ichiro Kato;Noriko Kimura;Tetsuya Nakazawa

  • Cyclic ADP-ribose modulates Ca2+ release channels for activation by physiological Ca2+ entry in bullfrog sympathetic neurons

    Shao Ying Hua;Takayuki Tokimasa;Shin Takasawa;Yasuhito Furuya

  • Regenerating gene protein may mediate gastric mucosal proliferation induced by hypergastrinemia in rats

    Hirokazu Fukui;Yoshikazu Kinoshita;Toru Maekawa;Akihiko Okada

  • Amelioration of Vasospasm After Subarachnoid Hemorrhage in Transgenic Mice Overexpressing CuZn–Superoxide Dismutase

    Hideyuki Kamii;Ichiro Kato;Hiroyuki Kinouchi;Pak H. Chan

  • Increased Expression of HIP/PAP and Regenerating Gene III in Human Inflammatory Bowel Disease and a Murine Bacterial Reconstitution Model

    Hitoshi Ogawa;Kouhei Fukushima;Hiroo Naito;Yuji Funayama

  • Structure, chromosomal localization, and expression of mouse reg genes, reg I and reg II. A novel type of reg gene, reg II, exists in the mouse genome.

    M. Unno;H. Yonekura;K.-I. Nakagawara;T. Watanabe

  • Reg gene expression is increased in rat gastric enterochromaffin-like cells following water immersion stress

    M. Asahara;S. Mushiake;S. Shimada;H. Fukui

  • Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38.

    Akira Tohgo;Shin Takasawa;Naoya Noguchi;Tetsuhiko Koguma

  • Cloning and characterization of cDNA encoding rat ADP-ribosyl cyclase / cyclic ADP-ribose hydrolase (homologue to human CD38) from islets of Langerhans

    Tetsuhiko Koguma;Shin Takasawa;Akira Tohgo;Tadahiro Karasawa

Frequent Co-Authors

Shin Takasawa
Shin Takasawa Nara Medical University
Yasuhiko Yamamoto
Yasuhiko Yamamoto Kanazawa University
Michiaki Unno
Michiaki Unno Tohoku University
Hiroshi Yamamoto
Hiroshi Yamamoto Komatsu University
Haruhiro Higashida
Haruhiro Higashida Kanazawa University
Masayoshi Takeuchi
Masayoshi Takeuchi Kanazawa Medical University
Tsutomu Chiba
Tsutomu Chiba Kyoto University
Mami Noda
Mami Noda Kyushu University
Masahide Asano
Masahide Asano Kyoto University
Alessandro Antonelli
Alessandro Antonelli University of Pisa

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