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Aurora Martinez

Aurora Martinez

D-Index & Metrics

Chemistry

D-Index
50
Citations
7567
World Ranking
14533
National Ranking
41

Biology and Biochemistry

D-Index
55
Citations
8710
World Ranking
15258
National Ranking
77

Overview

Aurora Martinez is affiliated with the University of Bergen in Norway. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology, Cellular and Molecular Neuroscience, Clinical Biochemistry, Genetics, and Physiology.

Their academic work covers a range of topics including Metabolism and Genetic Disorders, Biochemical and Molecular Research, Amino Acid Enzymes and Metabolism, Protein Structure and Dynamics, Enzyme Structure and Function, Porphyrin Metabolism and Disorders, and Mitochondrial Function and Pathology.

Martinez has published articles in several frequent venues such as Nature Communications, Journal of Inherited Metabolic Disease, bioRxiv (Cold Spring Harbor Laboratory), FEBS Journal, and Journal of Molecular Biology.

  • Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation, 2022, Nature Communications
  • Acute Intermittent Porphyria: An Overview of Therapy Developments and Future Perspectives Focusing on Stabilisation of HMBS and Proteostasis Regulators, 2021, International Journal of Molecular Sciences
  • Arc self-association and formation of virus-like capsids are mediated by an N-terminal helical coil motif, 2020, FEBS Journal
  • Pathogenic variants of DNAJC12 and evaluation of the encoded cochaperone as a genetic modifier of hyperphenylalaninemia, 2020, Human Mutation
  • Potassium channels in behavioral brain disorders. Molecular mechanisms and therapeutic potential: A narrative review, 2023, Neuroscience & Biobehavioral Reviews

Martinez has collaborated frequently with several co-authors, including Marte I. Flydal, Jarl Underhaug, Jan Haavik, Helene J. Bustad, and Juha P. Kallio, reflecting ongoing cooperative research efforts.

Best Publications

  • cAMP Analog Mapping of Epac1 and cAMP Kinase DISCRIMINATING ANALOGS DEMONSTRATE THAT Epac AND cAMP KINASE ACT SYNERGISTICALLY TO PROMOTE PC-12 CELL NEURITE EXTENSION

    Anne E. Christensen;Frode Selheim;Johan de Rooij;Sarah Dremier

  • Expression of recombinant human phenylalanine hydroxylase as fusion protein in Escherichia coli circumvents proteolytic degradation by host cell proteases. Isolation and characterization of the wild-type enzyme.

    A Martinez;P M Knappskog;S Olafsdottir;A P Døskeland

  • Crystal structure of the catalytic domain of human phenylalanine hydroxylase reveals the structural basis for phenylketonuria.

    Heidi Erlandsen;Fabrizia Fusetti;Fabrizia Fusetti;Fabrizia Fusetti;Aurora Martinez;Edward Hough

  • Phenylalanine hydroxylase: function, structure, and regulation.

    Marte I. Flydal;Aurora Martinez

  • Predicted Effects of Missense Mutations on Native-State Stability Account for Phenotypic Outcome in Phenylketonuria, a Paradigm of Misfolding Diseases

    Angel L. Pey;François Stricher;Luis Serrano;Aurora Martinez

  • Correction of kinetic and stability defects by tetrahydrobiopterin in phenylketonuria patients with certain phenylalanine hydroxylase mutations.

    Heidi Erlandsen;Angel L. Pey;Angel L. Pey;Alejandra Gámez;Belén Pérez

  • Identification of pharmacological chaperones as potential therapeutic agents to treat phenylketonuria

    Angel L. Pey;Ming Ying;Nunilo Cremades;Adrian Velazquez-Campoy

  • Epac1 and cAMP-dependent Protein Kinase Holoenzyme Have Similar cAMP Affinity, but Their cAMP Domains Have Distinct Structural Features and Cyclic Nucleotide Recognition

    Khanh Kim Dao;Knut Teigen;Reidun Kopperud;Erlend Hodneland

  • The 14-3-3 proteins in regulation of cellular metabolism

    Rune Kleppe;Aurora Martinez;Stein Ove Døskeland;Jan Haavik;Jan Haavik

  • Biallelic Mutations in DNAJC12 Cause Hyperphenylalaninemia, Dystonia, and Intellectual Disability

    Yair Anikster;Yair Anikster;Tobias B. Haack;Thierry Vilboux;Ben Pode-Shakked;Ben Pode-Shakked

  • Purification and characterization of two trypsin-like enzymes from the digestive tract of anchovy Engraulis encrasicholus.

    Aurora Martínez;Ragnar L. Olsen;Juan Luis Serra

  • Mechanisms underlying responsiveness to tetrahydrobiopterin in mild phenylketonuria mutations.

    Angel L Pey;Belén Pérez;Lourdes R Desviat;Maria Angeles Martínez

  • Principal component and normal mode analysis of proteins; a quantitative comparison using the GroEL subunit

    Lars Skjaerven;Aurora Martinez;Nathalie Reuter

  • Recombinant human tyrosine hydroxylase isozymes. Reconstitution with iron and inhibitory effect of other metal ions.

    Jan Haavik;Beatrice Le Bourdelles;Aurora Martinez;Torgeir Flatmark

  • Structure/function relationships in human phenylalanine hydroxylase. Effect of terminal deletions on the oligomerization, activation and cooperativity of substrate binding to the enzyme.

    Per M. Knappskog;Torgeir Flatmark;Johanna M. Aarden;Jan Haavik

  • L-phenylalanine binding and domain organization in human phenylalanine hydroxylase: a differential scanning calorimetry study.

    Matthias Thorolfsson;Beatriz Ibarra-Molero;Peter Fojan;Steffen B. Petersen

  • Structural and functional properties of isocitrate dehydrogenase from the psychrophilic bacterium Desulfotalea psychrophila reveal a cold-active enzyme with an unusual high thermal stability.

    Anita-Elin Fedøy;Nannan Yang;Aurora Martinez;Hanna-Kirsti S. Leiros

  • Allosteric mechanisms in ACT domain containing enzymes involved in amino acid metabolism.

    J. S. Liberles;M. Thórólfsson;A. Martínez

  • A structural approach into human tryptophan hydroxylase and its implications for the regulation of serotonin biosynthesis.

    Aurora Martinez;Per M. Knappskog;Jan Haavik

  • Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation

    Unknown

  • pH-dependent release of catecholamines from tyrosine hydroxylase and the effect of phosphorylation of Ser-40.

    J. Haavik;A. Martinez;T. Fiatmark

Frequent Co-Authors

Jan Haavik
Jan Haavik University of Bergen
Torgeir Flatmark
Torgeir Flatmark University of Bergen
Beat Thöny
Beat Thöny University of Zurich
Nenad Blau
Nenad Blau University of Zurich
Raymond C. Stevens
Raymond C. Stevens University of Southern California
Stein Ove Døskeland
Stein Ove Døskeland University of Bergen
José M. Valpuesta
José M. Valpuesta Spanish National Research Council
Catharina Svanborg
Catharina Svanborg Lund University
Wolfgang Pfleiderer
Wolfgang Pfleiderer University of Konstanz
Angela M. Gronenborn
Angela M. Gronenborn University of Pittsburgh

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