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Gregory J. Kaczorowski

Gregory J. Kaczorowski

D-Index & Metrics

Chemistry

D-Index
69
Citations
16000
World Ranking
6234
National Ranking
1895

Overview

Gregory J. Kaczorowski is affiliated with MSD in the United States and conducts research primarily within the fields of biochemistry, genetics, and molecular biology. Their scholarly contributions focus on several interconnected topics such as ion channel regulation and function, nicotinic acetylcholine receptors study, neuroscience and neuropharmacology research, amino acid enzymes and metabolism, epigenetics and DNA methylation, as well as cancer, hypoxia, and metabolism.

The researcher has published papers in notable scientific journals, including:

  • Ion Channels as Therapeutic Drug Targets, 2021, published in Burger's Medicinal Chemistry and Drug Discovery
  • Metabolomics analysis of SNAT2-deficient cells: Implications for the discovery of selective small-molecule inhibitors of an amino acid transporter, 2025, published in Journal of Biological Chemistry

Frequent co-authors collaborating with Kaczorowski include:

  • María L. García
  • Jessica C Koe
  • Yong-Wei Zhong
  • Kiana Pashaoskooie
  • Seth J. Parker

The publications are largely situated in molecular biology, cellular and molecular neuroscience, biochemistry, and cancer research. Specifically, the subfields represented in their work include:

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Biochemistry
  • Cancer Research

Research topics that underscore Kaczorowski's work span multiple areas of biological and medical research with a notable concentration on the mechanisms and roles of ion channels and receptors. The main research themes are:

  • Ion channel regulation and function
  • Nicotinic Acetylcholine Receptors Study
  • Neuroscience and Neuropharmacology Research
  • Amino Acid Enzymes and Metabolism
  • Epigenetics and DNA Methylation
  • Cancer, Hypoxia, and Metabolism

Best Publications

  • Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus.

    A Galvez;G Gimenez-Gallego;J P Reuben;L Roy-Contancin

  • Functional colocalization of calcium and calcium-gated potassium channels in control of transmitter release

    Richard Robitaille;Maria L. Garcia;Gregory J. Kaczorowski;Milton P. Chariton

  • Primary sequence and immunological characterization of beta-subunit of high conductance Ca(2+)-activated K+ channel from smooth muscle.

    H G Knaus;K Folander;M Garcia-Calvo;M L Garcia

  • Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels.

    M Garcia-Calvo;R J Leonard;J Novick;S P Stevens

  • Distribution of high-conductance Ca(2+)-activated K+ channels in rat brain: targeting to axons and nerve terminals

    H.-G. Knaus;C. Schwarzer;R. O. A. Koch;A. Eberhart

  • Purification, sequence, and model structure of charybdotoxin, a potent selective inhibitor of calcium-activated potassium channels

    Guillermo Gimenez-Gallego;Manuel A. Navia;John P. Reuben;George M. Katz

  • High-conductance calcium-activated potassium channels; structure, pharmacology, and function.

    Gregory J. Kaczorowski;Hans Günther Knaus;Reid J. Leonard;Owen B. McManus

  • ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

    William A. Schmalhofer;Jeffrey Calhoun;Rachel Burrows;Timothy Bailey

  • Voltage-gated potassium channels regulate calcium-dependent pathways involved in human T lymphocyte activation.

    C S Lin;R C Boltz;J T Blake;M Nguyen

  • Subunit composition of the high conductance calcium-activated potassium channel from smooth muscle, a representative of the mSlo and slowpoke family of potassium channels.

    H G Knaus;M Garcia-Calvo;G J Kaczorowski;M L Garcia

  • Purification and reconstitution of the high-conductance, calcium-activated potassium channel from tracheal smooth muscle.

    M Garcia-Calvo;H G Knaus;O B McManus;K M Giangiacomo

  • Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle.

    R J Winquist;L A Heaney;A A Wallace;E P Baskin

  • Inhibition of Na+/Ca2+ exchange in membrane vesicle and papillary muscle preparations from guinea pig heart by analogs of amiloride.

    P K Siegl;E J Cragoe;M J Trumble;G J Kaczorowski

  • Ion Channels as Drug Targets: The Next GPCRs

    Gregory J. Kaczorowski;Owen B. McManus;Birgit T. Priest;Maria L. Garcia

  • An activator of calcium-dependent potassium channels isolated from a medicinal herb.

    O B McManus;G H Harris;K M Giangiacomo;P Feigenbaum

  • Selective inhibition of relaxation of guinea-pig trachea by charybdotoxin, a potent Ca(++)-activated K+ channel inhibitor.

    T R Jones;L Charette;M L Garcia;G J Kaczorowski

  • Mechanism of lactose translocation in membrane vesicles from Escherichia coli. 1. Effect of pH on efflux, exchange, and counterflow.

    Gregory J. Kaczorowski;H. R. Kaback

  • Use of toxins to study potassium channels.

    M L Garcia;A Galvez;M Garcia-Calvo;V F King

  • Pharmacology of voltage-gated and calcium-activated potassium channels.

    Gregory J Kaczorowski;Maria L Garcia

  • Interaction of tetrandrine with slowly inactivating calcium channels. Characterization of calcium channel modulation by an alkaloid of Chinese medicinal herb origin.

    V F King;M L Garcia;D Himmel;J P Reuben

  • Inhibition of Na+/Ca2+ exchange in pituitary plasma membrane vesicles by analogues of amiloride.

    Gregory J. Kaczorowski;Francisco Barros;Judy K. Dethmers;Mayme J. Trumble

Frequent Co-Authors

Maria L. Garcia
Maria L. Garcia MSD (United States)
William J. Martin
William J. Martin National Institutes of Health
Deborah L. Zink
Deborah L. Zink Weizenbaum-Institut
Sophie Roy
Sophie Roy MSD (United States)
Michael H. Fisher
Michael H. Fisher MSD (United States)
Christopher T. Walsh
Christopher T. Walsh Stanford University
Jesús Vázquez
Jesús Vázquez Spanish National Centre for Cardiovascular Research
Sheo B. Singh
Sheo B. Singh MSD (United States)
Gloria C. Koo
Gloria C. Koo Hospital for Special Surgery
Matthew J. Wyvratt
Matthew J. Wyvratt Medicines for Malaria Venture

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