D-Index & Metrics Best Publications

Sheo B. Singh

MSD (United States)
United States

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name Citations Publications World Ranking National Ranking

Chemistry D-index 63 Citations 14,557 243 World Ranking 5310 National Ranking 1733

Biology and Biochemistry D-index 63 Citations 14,808 245 World Ranking 6574 National Ranking 3069

Overview

What is he best known for?

The fields of study Sheo B. Singh is best known for:

Enzyme
Amino acid
Gene

In his research, Natural product is intimately related to Stereochemistry, which falls under the overarching field of Moiety. His work on Natural product is being expanded to include thematically relevant topics such as Stereochemistry. Research on Antibacterial activity and Staphylococcus aureus is a part of his Bacteria study. His Staphylococcus aureus study often links to related topics such as Genetics. He connects Genetics with Gene in his study. His work often combines Gene and In vitro studies. His study on In vitro is mostly dedicated to connecting different topics, such as IC50. He brings together Biochemistry and DNA to produce work in his papers. He undertakes interdisciplinary study in the fields of Enzyme and Bacteria through his works.

His most cited work include:

Platensimycin is a selective FabF inhibitor with potent antibiotic properties (737 citations)
Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase (489 citations)
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties (340 citations)

What are the main themes of his work throughout his whole career to date

Among his Stereochemistry studies, you can observe a synthesis of other disciplines of science such as Enzyme and Organic chemistry. His work blends Organic chemistry and Stereochemistry studies together. In his study, Sheo B. Singh carries out multidisciplinary Biochemistry and Biotechnology research. His research combines Staphylococcus aureus and Genetics. In most of his Staphylococcus aureus studies, his work intersects topics such as Genetics. Sheo B. Singh applies his multidisciplinary studies on In vitro and Gene in his research. He performs integrative Gene and In vitro research in his work. His work in Microbiology is not limited to one particular discipline; it also encompasses Antibiotics. His Microbiology research extends to Antibiotics, which is thematically connected.

Sheo B. Singh most often published in these fields:

Biochemistry (79.78%)
Stereochemistry (65.73%)
Genetics (33.15%)

What were the highlights of his more recent work (between 2016-2022)?

Genetics (75.00%)
Biochemistry (75.00%)
Antibiotics (50.00%)

In recent works Sheo B. Singh was focusing on the following fields of study:

His research on Bacteria is centered around Flora (microbiology) and Antibacterial activity. His study connects Bacteria and Antibacterial activity. His Genetics study frequently links to adjacent areas such as In vivo. His Genetics research extends to In vivo, which is thematically connected. His study in In vitro extends to Biochemistry with its themes. His In vitro study often links to related topics such as Potency. His research ties Biochemistry and Potency together. He brings together Antibiotics and Moxifloxacin to produce work in his papers. Sheo B. Singh connects Moxifloxacin with Antibiotics in his research.

Between 2016 and 2022, his most popular works were:

What is an “ideal” antibiotic? Discovery challenges and path forward (125 citations)
Using [²H]water to quantify the contribution of de novo palmitate synthesis in plasma: enabling back-to-back studies (10 citations)
Discovery and Development of Dolastatin 10-Derived Antibody Drug Conjugate Anticancer Drugs (9 citations)

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Platensimycin is a selective FabF inhibitor with potent antibiotic properties

Jun Wang;Stephen M. Soisson;Katherine Young;Wesley Shoop;Wesley Shoop.
Nature (2006)

941 Citations

Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

George Pettit;S. B. Singh;E. Hamel;C. M. Lin.
Cellular and Molecular Life Sciences (1989)

905 Citations

Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase

Sandra J. Darkin-Rattray;Anne M. Gurnett;Robert W. Myers;Paula M. Dulski.
Proceedings of the National Academy of Sciences of the United States of America (1996)

670 Citations

Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6

George R. Pettit;Sheo Bux Singh;Michael R. Boyd;Michael R. Boyd;Ernest Hamel;Ernest Hamel.
Journal of Medicinal Chemistry (1995)

508 Citations

Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.

Jun Wang;Srinivas Kodali;Sang Ho Lee;Andrew Galgoci.
Proceedings of the National Academy of Sciences of the United States of America (2007)

423 Citations

Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum

George R. Pettit;Sheo Bux Singh;Margaret L. Niven;Ernest Hamel.
Journal of Natural Products (1987)

418 Citations

Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.

C M Lin;S B Singh;P S Chu;R O Dempcy.
Molecular Pharmacology (1988)

412 Citations

Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.

J. B. Gibbs;D. L. Pompliano;S. D. Mosser;E. Rands.
Journal of Biological Chemistry (1993)

397 Citations

Empirical antibacterial drug discovery--foundation in natural products.

Sheo B. Singh;John F. Barrett.
Biochemical Pharmacology (2006)

373 Citations

The absolute configuration and synthesis of natural (−)-dolastatin 10

George R. Pettit;Sheo Bux Singh;Fiona Hogan;Paul Lloyd-Williams.
Journal of the American Chemical Society (1989)

284 Citations

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