World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
70
Citations
18401
World Ranking
5824
National Ranking
1789

Biology and Biochemistry

D-Index
70
Citations
18251
World Ranking
6986
National Ranking
3215

Overview

Sheo B. Singh is affiliated with MSD (United States) and has a research focus that spans several interdisciplinary fields, primarily within Medicine and Biochemistry, Genetics and Molecular Biology. The scientist's work frequently contributes to subfields such as Molecular Biology, Pharmacology, Organic Chemistry, Infectious Diseases, and Radiology, Nuclear Medicine and Imaging.

Singh's research explores topics including Microbial Natural Products and Biosynthesis, Chemical Synthesis and Analysis, Genomics and Phylogenetic Studies, Monoclonal and Polyclonal Antibodies Research, HER2/EGFR in Cancer Research, Synthesis and Biological Activity, and Phytochemical Compounds Biological Activities.

Research contributions have been published extensively in journals such as:

  • Journal of Natural Products
  • Natural Product Reports
  • Bioorganic & Medicinal Chemistry Letters
  • The Journal of Antibiotics
  • Journal of Modern Medicine

Some notable recent papers authored by Sheo B. Singh include:

  • Discovery and Development of Dolastatin 10-Derived Antibody Drug Conjugate Anticancer Drugs, 2022, Journal of Natural Products
  • Discovery, synthesis, activities, structure-activity relationships, and clinical development of combretastatins and analogs as anticancer drugs. A comprehensive review, 2023, Natural Product Reports
  • History and Prospects of Drug Discovery and Development Collaboration between Industry and Academia, 2024, Journal of Natural Products
  • Nocathiacin, Thiazomycin, and Polar Analogs Are Highly Effective Agents against Toxigenic Clostridioides difficile, 2022, Journal of Natural Products
  • Structure activity relationship of N-1 substituted 1,5-naphthyrid-2-one analogs of oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents (Part-9), 2022, Bioorganic & Medicinal Chemistry Letters

Frequent collaborators in research include John B. Perkins, Vincent P. Gullo, Lynn Miesel, Olga Genilloud, and Gary E. Martin.

Best Publications

  • Platensimycin is a selective FabF inhibitor with potent antibiotic properties

    Jun Wang;Stephen M. Soisson;Katherine Young;Wesley Shoop;Wesley Shoop

  • Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

    George Pettit;S. B. Singh;E. Hamel;C. M. Lin

  • Apicidin: A novel antiprotozoal agent that inhibits parasite histone deacetylase

    Sandra J. Darkin-Rattray;Anne M. Gurnett;Robert W. Myers;Paula M. Dulski

  • Antineoplastic Agents. 291. Isolation and Synthesis of Combretastatins A-4, A-5, and A-6

    George R. Pettit;Sheo Bux Singh;Michael R. Boyd;Michael R. Boyd;Ernest Hamel;Ernest Hamel

  • Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.

    Jun Wang;Srinivas Kodali;Sang Ho Lee;Andrew Galgoci

  • Isolation, structure, and synthesis of combretastatins A-1 and B-1, potent new inhibitors of microtubule assembly, derived from Combretum caffrum

    George R. Pettit;Sheo Bux Singh;Margaret L. Niven;Ernest Hamel

  • Interactions of tubulin with potent natural and synthetic analogs of the antimitotic agent combretastatin: a structure-activity study.

    C M Lin;S B Singh;P S Chu;R O Dempcy

  • Empirical antibacterial drug discovery--foundation in natural products.

    Sheo B. Singh;John F. Barrett

  • Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.

    J. B. Gibbs;D. L. Pompliano;S. D. Mosser;E. Rands

  • Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy.

    Sheo B Singh;Hiranthi Jayasuriya;John G Ondeyka;Kithsiri B Herath

  • The absolute configuration and synthesis of natural (−)-dolastatin 10

    George R. Pettit;Sheo Bux Singh;Fiona Hogan;Paul Lloyd-Williams

  • Discovery of a Small Molecule That Inhibits Cell Division by Blocking FtsZ, a Novel Therapeutic Target of Antibiotics *

    Jun Wang;Andrew Galgoci;Srinivas Kodali;Kithsiri B. Herath

  • Discovery of FabH/FabF Inhibitors from Natural Products

    Katherine Young;Hiranthi Jayasuriya;John G. Ondeyka;Kithsiri Herath

  • Isolation and Structure of Platencin: A FabH and FabF Dual Inhibitor with Potent Broad-Spectrum Antibiotic Activity

    Hiranthi Jayasuriya;Kithsiri B. Herath;Chaowei Zhang;Deborah L. Zink

  • Antineoplastic agents, 120. Pancratium littorale.

    George R. Pettit;Venkatswamy Gaddamidi;Delbert L. Herald;Sheo Bux Singh

  • What is an "ideal" antibiotic? Discovery challenges and path forward.

    Sheo B. Singh;Katherine Young;Lynn L. Silver

  • Equisetin and a novel opposite stereochemical homolog phomasetin, two fungal metabolites as inhibitors of HIV-1 integrase

    Sheo B. Singh;Deborah L. Zink;Michael A. Goetz;Anne W. Dombrowski

  • Antineoplastic agents, 122. Constituents of Combretum caffrum.

    George R. Pettit;Gordon M. Cragg;Sheo Bux Singh

  • Nodulisporic Acid A, a Novel and Potent Insecticide from a Nodulisporium Sp. Isolation, Structure Determination, and Chemical Transformations

    John G. Ondeyka;Gregory L. Helms;Otto D. Hensens;Michael A. Goetz

  • Discovery of Kibdelomycin, A Potent New Class of Bacterial Type II Topoisomerase Inhibitor by Chemical-Genetic Profiling in Staphylococcus aureus

    John W. Phillips;Michael A. Goetz;Scott K. Smith;Deborah L. Zink

  • A Potent Synthetic LXR Agonist Is More Effective than Cholesterol Loading at Inducing ABCA1 mRNA and Stimulating Cholesterol Efflux

    Carl P. Sparrow;Joanne Baffic;My-Hanh Lam;Erik G. Lund

Frequent Co-Authors

Deborah L. Zink
Deborah L. Zink Weizenbaum-Institut
Gerald F. Bills
Gerald F. Bills The University of Texas Health Science Center at Houston
George R. Pettit
George R. Pettit Arizona State University
Daria J. Hazuda
Daria J. Hazuda MSD (United States)
Fernando Pelaez
Fernando Pelaez Spanish National Cancer Research Centre
Ziqiang Guan
Ziqiang Guan Duke University
David B. Olsen
David B. Olsen MSD (United States)
Richard G. Ball
Richard G. Ball MSD (United States)
Dennis M. Schmatz
Dennis M. Schmatz MSD (United States)
Mary Motyl
Mary Motyl MSD (United States)

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