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D-Index & Metrics

Biology and Biochemistry

D-Index
76
Citations
26544
World Ranking
4965
National Ranking
77

Overview

Jan Steyaert is affiliated with the Vrije Universiteit Brussel in Belgium. Their research spans multiple areas within biochemistry, genetics, molecular biology, and medicine, with an emphasis on molecular biology and related subfields including radiology, nuclear medicine and imaging, cellular and molecular neuroscience, cell biology, and physiology.

Their main areas of scientific inquiry incorporate topics such as monoclonal and polyclonal antibodies research, RNA and protein synthesis mechanisms, receptor mechanisms and signaling, glycosylation and glycoproteins research, enzyme structure and function, lipid membrane structure and behavior, as well as protein kinase regulation and GTPase signaling.

Jan Steyaert has contributed extensively to the scientific literature, with key recent publications including:

  • "Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM," 2021, Nature Methods
  • "Nanobody-enabled monitoring of kappa opioid receptor states," 2020, Nature Communications
  • "Structure, substrate recognition and initiation of hyaluronan synthase," 2022, Nature
  • "Nanobodies to study protein conformational states," 2020, Current Opinion in Structural Biology
  • "Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins," 2021, Proceedings of the National Academy of Sciences

Their frequent coauthors include Els Pardon, Alexandre Wohlkönig, Tomasz Uchański, Thomas Zögg, and Wim Versées, reflecting a collaborative research network.

Jan Steyaert's work is regularly published in several scientific journals and venues. The most frequent publication sources are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Biophysical Journal
  • EMPIAR dataset
  • Proceedings of the National Academy of Sciences

Best Publications

  • Crystal structure of the β2 adrenergic receptor-Gs protein complex.

    Søren G. F. Rasmussen;Brian T. DeVree;Yaozhong Zou;Andrew C. Kruse

  • Structure of a nanobody-stabilized active state of the β2 adrenoceptor

    Søren G F Rasmussen;Hee Jung Choi;Juan Jose Fung;Els Pardon

  • Activation and allosteric modulation of a muscarinic acetylcholine receptor

    Andrew C. Kruse;Aaron M. Ring;Aashish Manglik;Jianxin Hu

  • Structural insights into µ-opioid receptor activation

    Weijiao Huang;Aashish Manglik;A. J. Venkatakrishnan;Toon Laeremans

  • A general protocol for the generation of Nanobodies for structural biology

    Els Pardon;Toon Laeremans;Sarah Triest;Søren G F Rasmussen

  • Conformational biosensors reveal GPCR signalling from endosomes

    Roshanak Irannejad;Jin C. Tomshine;Jon R. Tomshine;Michael Chevalier

  • GABAAreceptor signalling mechanisms revealed by structural pharmacology.

    S. Masiulis;R. Desai;T. Uchanski;I. Serna Martin

  • Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor

    Tao Che;Susruta Majumdar;Saheem A. Zaidi;Pauline Ondachi

  • Distinct conformations of GPCR–β-arrestin complexes mediate desensitization, signaling, and endocytosis

    Thomas J. Cahill;Alex R.B. Thomsen;Jeffrey T. Tarrasch;Bianca Plouffe

  • Cryo-EM structure of the human α1β3γ2 GABA A receptor in a lipid bilayer.

    Laverty D;Desai R;Uchański T;Masiulis S

  • The F plasmid CcdB protein induces efficient ATP-dependent DNA cleavage by gyrase.

    Philippe Bernard;Katherine E. Kézdy;Laurence Van Melderen;Jan Steyaert

  • Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation

    Dean P Staus;Ryan T Strachan;Aashish Manglik;Biswaranjan Pani

  • A Genetically Encoded Biosensor Reveals Location Bias of Opioid Drug Action

    Miriam Carolin Stoeber;Damien Jullié;Braden T Lobingier;Toon Laeremans

  • Influence of the π–π interaction on the hydrogen bonding capacity of stacked DNA/RNA bases

    Pierre Mignon;Stefan Loverix;Jan Steyaert;Paul Geerlings

  • Nanobodies to Study G Protein-Coupled Receptor Structure and Function.

    Aashish Manglik;Brian K Kobilka;Jan Steyaert

  • Allosteric coupling from G protein to the agonist-binding pocket in GPCRs

    Brian T. Devree;Jacob P. Mahoney;Gisselle A. Vélez-Ruiz;Soren G.F. Rasmussen

  • Structural insights into the activation of metabotropic glutamate receptors.

    Antoine Koehl;Hongli Hu;Dan Feng;Bingfa Sun

  • Structural flexibility of the Gαs α-helical domain in the β 2-adrenoceptor Gs complex

    Gerwin H. Westfield;Søren G. F. Rasmussen;Søren G. F. Rasmussen;Min Su;Somnath Dutta

  • Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain.

    Andrew A.B. Ward;Paul Szewczyk;Vinciane Grimard;Chang-Wook Lee

  • Propagation of conformational changes during μ-opioid receptor activation

    Rémy Sounier;Camille Mas;Jan Steyaert;Toon Laeremans

Frequent Co-Authors

Els Pardon
Els Pardon Vrije Universiteit Brussel
Brian K. Kobilka
Brian K. Kobilka Stanford University
Lode Wyns
Lode Wyns Vrije Universiteit Brussel
Remy Loris
Remy Loris Vrije Universiteit Brussel
Roger K. Sunahara
Roger K. Sunahara University of California, San Diego
William I. Weis
William I. Weis Stanford University
A. Radu Aricescu
A. Radu Aricescu MRC Laboratory of Molecular Biology
Wim G. J. Hol
Wim G. J. Hol University of Washington
Keith W. Miller
Keith W. Miller Harvard University
Koen Augustyns
Koen Augustyns University of Antwerp

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