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Biology and Biochemistry

D-Index
70
Citations
21054
World Ranking
6921
National Ranking
527

Overview

Christopher G. Tate is affiliated with the MRC Laboratory of Molecular Biology in the United Kingdom. Their research centers on the biochemical and molecular biology aspects of receptor function and signaling, with a particular focus on G protein-coupled receptors (GPCRs).

Their scientific contributions are distributed primarily across the fields of Biochemistry, Genetics and Molecular Biology and Neuroscience, with subfields including Molecular Biology, Cellular and Molecular Neuroscience, Spectroscopy, Radiology, Nuclear Medicine and Imaging, and Sensory Systems.

The major topics covered in their work consist of:

  • Receptor Mechanisms and Signaling
  • Mass Spectrometry Techniques and Applications
  • Neuropeptides and Animal Physiology
  • Monoclonal and Polyclonal Antibodies Research
  • Neuroscience and Neuropharmacology Research
  • Lipid Membrane Structure and Behavior
  • Photoreceptor and Optogenetics Research

Frequent co-authors collaborating with Christopher G. Tate include:

  • Patricia C. Edwards
  • Anastasiia Gusach
  • Yang Lee
  • Vaithish Velazhahan
  • Nagarajan Vaidehi

The most common publication venues for their research are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Biochemistry
  • Nature Communications
  • Journal of Visualized Experiments

Recent significant papers authored or co-authored by Christopher G. Tate include:

  • Impact of GPCR Structures on Drug Discovery, 2020, Cell
  • Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor, 2020, Nature
  • Structure determination of GPCRs: cryo-EM compared with X-ray crystallography, 2021, Biochemical Society Transactions
  • Structure of the class D GPCR Ste2 dimer coupled to two G proteins, 2020, Nature
  • How Do Branched Detergents Stabilize GPCRs in Micelles?, 2020, Biochemistry

Best Publications

  • Structure of a beta1-adrenergic G-protein-coupled receptor.

    Tony Warne;Maria J. Serrano-Vega;Jillian G. Baker;Rouslan Moukhametzianov

  • Molecular signatures of G-protein-coupled receptors.

    A. J. Venkatakrishnan;Xavier Deupi;Guillaume Lebon;Christopher G. Tate

  • Agonist-bound adenosine A2A receptor structures reveal common features of GPCR activation

    Guillaume Lebon;Tony Warne;Patricia C. Edwards;Kirstie A. Bennett

  • The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor.

    Tony Warne;Rouslan Moukhametzianov;Jillian G. Baker;Rony Nehmé

  • Structure of the adenosine A(2A) receptor in complex with ZM241385 and the xanthines XAC and caffeine

    Andrew S. Doré;Nathan Robertson;James C. Errey;Irene Ng

  • Structure of the agonist-bound neurotensin receptor

    Jim F. White;Nicholas Noinaj;Yoko Shibata;Yoko Shibata;James Love

  • Conformational thermostabilization of the β1-adrenergic receptor in a detergent-resistant form

    Maria J. Serrano-Vega;Francesca Magnani;Yoko Shibata;Christopher G. Tate

  • Overexpression of integral membrane proteins for structural studies

    Grisshammer R;Tate Cg

  • Overcoming barriers to membrane protein structure determination

    Roslyn M. Bill;Peter J. F. Henderson;So Iwata;Edmund R. S. Kunji

  • Structure of the adenosine A2A receptor bound to an engineered G protein

    Byron Carpenter;Rony Nehmé;Tony Warne;Andrew G. W. Leslie

  • Impact of GPCR Structures on Drug Discovery

    Miles Congreve;Chris de Graaf;Nigel A. Swain;Christopher G. Tate

  • Universal allosteric mechanism for Gα activation by GPCRs

    Tilman Flock;Charles N. J. Ravarani;Dawei Sun;Dawei Sun;A. J. Venkatakrishnan

  • PtdIns(4,5)P2 stabilizes active states of GPCRs and enhances selectivity of G-protein coupling

    Hsin-Yung Yen;Kin Kuan Hoi;Idlir Liko;George Hedger

  • Mini G protein probes for active G protein-coupled receptors (GPCRs) in live cells.

    Qingwen Wan;Najeah Okashah;Asuka Inoue;Rony Nehmé

  • Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region

    A. J. Venkatakrishnan;Xavier Deupi;Guillaume Lebon;Guillaume Lebon;Guillaume Lebon;Franziska M. Heydenreich;Franziska M. Heydenreich;Franziska M. Heydenreich

  • Overexpression of mammalian integral membrane proteins for structural studies

    C.G. Tate

  • Co-evolving stability and conformational homogeneity of the human adenosine A2a receptor

    Francesca Magnani;Yoko Shibata;Maria J. Serrano-Vega;Christopher G. Tate

  • Crystal structures of a stabilized β1-adrenoceptor bound to the biased agonists bucindolol and carvedilol.

    Tony Warne;Patricia C. Edwards;Andrew G.W. Leslie;Christopher G. Tate

  • Cryo-EM structure of the adenosine A2A receptor coupled to an engineered heterotrimeric G protein

    Javier García-Nafría;Yang Lee;Xiaochen Bai;Byron Carpenter

  • Mini-G proteins: Novel tools for studying GPCRs in their active conformation.

    Rony Nehmé;Byron Carpenter;Ankita Singhal;Annette Strege

Frequent Co-Authors

Gebhard F. X. Schertler
Gebhard F. X. Schertler Paul Scherrer Institute
Andrew G. W. Leslie
Andrew G. W. Leslie MRC Laboratory of Molecular Biology
Peter J. F. Henderson
Peter J. F. Henderson University of Leeds
Dmitry B. Veprintsev
Dmitry B. Veprintsev University of Nottingham
Michael J. A. Tanner
Michael J. A. Tanner University of Bristol
Michael J. Betenbaugh
Michael J. Betenbaugh Johns Hopkins University
Edmund R. S. Kunji
Edmund R. S. Kunji University of Cambridge
Prashant Kumar
Prashant Kumar University of Surrey
Carol V. Robinson
Carol V. Robinson University of Oxford
M. Madan Babu
M. Madan Babu St. Jude Children's Research Hospital

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