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Genetics

D-Index
79
Citations
33776
World Ranking
1619
National Ranking
745

Overview

M. Madan Babu is affiliated with St. Jude Children's Research Hospital in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, comprising a total of 73 publications. Within these, they have specialized in subfields such as Molecular Biology, Cellular and Molecular Neuroscience, Oncology, Immunology, and Biomedical Engineering.

Their scientific work covers several main topics, including:

  • Receptor Mechanisms and Signaling
  • RNA and Protein Synthesis Mechanisms
  • Neuropeptides and Animal Physiology
  • Protein Structure and Dynamics
  • RNA Research and Splicing
  • Immune Cell Function and Interaction
  • CAR-T Cell Therapy Research

Some recent papers authored or coauthored by this scientist include:

  • GPCR activation mechanisms across classes and macro/microscales, 2021, Nature Structural & Molecular Biology
  • Structural and functional characterization of G protein-coupled receptors with deep mutational scanning, 2020, eLife
  • A Global Map of G Protein Signaling Regulation by RGS Proteins, 2020, Cell
  • Combinatorial expression of GPCR isoforms affects signalling and drug responses, 2020, Nature
  • Context-Specific Striatal Astrocyte Molecular Responses Are Phenotypically Exploitable, 2020, Neuron

The scientist has collaborated frequently with several researchers, including:

  • Andrew B. Kleist
  • Balaji Santhanam
  • Maria Martí-Solano
  • Ilaria Iacobucci
  • Charles G. Mullighan

Madan Babu's publications are often found in prominent scientific journals and venues. They have multiple works published in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nature Structural & Molecular Biology
  • Science
  • Cell

Best Publications

  • The Transcriptional Landscape of the Mammalian Genome

    P. Carninci;T. Kasukawa;S. Katayama;J. Gough

  • Classification of intrinsically disordered regions and proteins.

    Robin van der Lee;Robin van der Lee;Marija Buljan;Benjamin Lang;Robert J. Weatheritt

  • Molecular signatures of G-protein-coupled receptors.

    A. J. Venkatakrishnan;Xavier Deupi;Guillaume Lebon;Christopher G. Tate

  • The genome of the social amoeba Dictyostelium discoideum

    L. Eichinger;J. A. Pachebat;J. A. Pachebat;G. Glöckner;M.-A. Rajandream

  • Genomic analysis of regulatory network dynamics reveals large topological changes

    Nicholas M. Luscombe;M. Madan Babu;Haiyuan Yu;Michael Snyder

  • Structure and evolution of transcriptional regulatory networks.

    M Madan Babu;Nicholas M Luscombe;L Aravind;Mark Gerstein

  • Intrinsically disordered proteins: regulation and disease

    M Madan Babu;Robin van der Lee;Natalia Sanchez de Groot;Jörg Gsponer

  • Gene regulatory network growth by duplication

    Sarah A Teichmann;M Madan Babu

  • Common activation mechanism of class A GPCRs.

    Qingtong Zhou;Dehua Yang;Meng Wu;Meng Wu;Yu Guo;Yu Guo

  • Pharmacogenomics of GPCR Drug Targets

    Alexander Sebastian Hauser;Alexander Sebastian Hauser;Sreenivas Chavali;Ikuo Masuho;Leonie Johanna Jahn

  • Mechanisms of signalling and biased agonism in G protein-coupled receptors

    Denise L Wootten;Arthur Christopoulos;Maria Marti-Solano;M. Madan Babu

  • Discovery of the principal specific transcription factors of Apicomplexa and their implication for the evolution of the AP2-integrase DNA binding domains

    S. Balaji;M. Madan Babu;Lakshminarayan M. Iyer;L. Aravind

  • A Million Peptide Motifs for the Molecular Biologist

    Peter Tompa;Peter Tompa;Norman E. Davey;Toby J. Gibson;M. Madan Babu

  • Tight regulation of unstructured proteins: from transcript synthesis to protein degradation.

    Jörg Gsponer;Matthias E. Futschik;Matthias E. Futschik;Matthias E. Futschik;Sarah A. Teichmann;M. Madan Babu

  • An Expanded Oct4 Interaction Network: Implications for Stem Cell Biology, Development, and Disease

    Mercedes Pardo;Benjamin Lang;Lu Yu;Haydn Prosser

  • The contribution of intrinsically disordered regions to protein function, cellular complexity, and human disease

    M. Madan Babu

  • Evolution of transcription factors and the gene regulatory network in Escherichia coli

    M. Madan Babu;Sarah A. Teichmann

  • Tissue-Specific Splicing of Disordered Segments that Embed Binding Motifs Rewires Protein Interaction Networks

    Marija Buljan;Marija Buljan;Guilhem Chalancon;Sebastian Eustermann;Gunter P. Wagner

  • Universal allosteric mechanism for Gα activation by GPCRs

    Tilman Flock;Charles N. J. Ravarani;Dawei Sun;Dawei Sun;A. J. Venkatakrishnan

  • Selectivity determinants of GPCR–G-protein binding

    Tilman Flock;Alexander S. Hauser;Nadia Lund;David E. Gloriam

Frequent Co-Authors

Sarah A. Teichmann
Sarah A. Teichmann University of Cambridge
L. Aravind
L. Aravind National Institutes of Health
Peter Tompa
Peter Tompa Vrije Universiteit Brussel
Monika Fuxreiter
Monika Fuxreiter University of Padua
Vladimir N. Uversky
Vladimir N. Uversky University of South Florida
Julian Gough
Julian Gough University of Bristol
Gebhard F. X. Schertler
Gebhard F. X. Schertler Paul Scherrer Institute
Dmitry B. Veprintsev
Dmitry B. Veprintsev University of Nottingham
A. Keith Dunker
A. Keith Dunker Indiana University
Nicholas M. Luscombe
Nicholas M. Luscombe The Francis Crick Institute

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