D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 59 Citations 13,603 185 World Ranking 8296 National Ranking 3760

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • DNA
  • Virus

His main research concerns Virology, Prodrug, Polymerase, Nucleoside and Biochemistry. His Virology research includes themes of Resistance mutation and Drug discovery. His Prodrug study introduces a deeper knowledge of Pharmacology.

His Polymerase research is multidisciplinary, relying on both NS5B, Hepatitis C virus, Nucleoside analogue, Molecular biology and RNA polymerase. His Nucleoside research is multidisciplinary, incorporating perspectives in Aryl and Adenosine. His work deals with themes such as P-glycoprotein and Allopurinol, which intersect with Biochemistry.

His most cited work include:

  • Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. (729 citations)
  • Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys (688 citations)
  • Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease (666 citations)

What are the main themes of his work throughout his whole career to date?

Adrian S. Ray spends much of his time researching Pharmacology, Prodrug, Virology, Nucleoside and Biochemistry. His Pharmacology study combines topics in areas such as Peripheral blood mononuclear cell and Kidney metabolism. The study incorporates disciplines such as Oral administration, Phosphoramidate, Adenosine and Metabolite in addition to Prodrug.

His Virology research focuses on Virus, Ebola virus and Hepatitis C virus. His Nucleoside research includes elements of Phosphonate, Organic chemistry, Reverse transcriptase and Ribose. Adrian S. Ray focuses mostly in the field of Biochemistry, narrowing it down to topics relating to Molecular biology and, in certain cases, Mitochondrial toxicity.

He most often published in these fields:

  • Pharmacology (26.94%)
  • Prodrug (26.42%)
  • Virology (21.24%)

What were the highlights of his more recent work (between 2016-2021)?

  • Pharmacology (26.94%)
  • Virology (21.24%)
  • Prodrug (26.42%)

In recent papers he was focusing on the following fields of study:

Adrian S. Ray mostly deals with Pharmacology, Virology, Prodrug, Acetyl-CoA carboxylase and Ebola virus. His work carried out in the field of Pharmacology brings together such families of science as Mitochondrial toxicity, IC50 and Anti fibrotic. His Virology study focuses on Virus in particular.

His studies deal with areas such as Phosphoramidate, Peripheral blood mononuclear cell and Nucleoside as well as Prodrug. Adrian S. Ray combines subjects such as Amino acid, Oral administration, Adenosine, Nucleoside triphosphate and Efflux with his study of Nucleoside. His biological study spans a wide range of topics, including Nucleoside analogue, Proofreading and Viral load.

Between 2016 and 2021, his most popular works were:

  • Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. (729 citations)
  • Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease (666 citations)
  • Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses (270 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • DNA
  • Virus

His primary areas of investigation include Virology, Lipogenesis, Ebola virus, Acetyl-CoA carboxylase and Nonalcoholic fatty liver disease. His study in the field of Viral replication and Viremia also crosses realms of Coronavirus. His biological study spans a wide range of topics, including Disease and Viral load.

His Ebola virus research integrates issues from Potency, Prodrug, Structure–activity relationship, Drug discovery and Viral shedding. His Prodrug research is multidisciplinary, incorporating perspectives in Marburgvirus, Ebolavirus, Adenosine and Nucleoside. His Nonalcoholic fatty liver disease research incorporates themes from Gastroenterology, Steatosis, Lipoprotein lipase and Fibrosis.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

Timothy P. Sheahan;Amy C. Sims;Rachel L. Graham;Vineet D. Menachery.
Science Translational Medicine (2017)

1454 Citations

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

Travis K. Warren;Robert Jordan;Michael K. Lo;Adrian S. Ray.
Nature (2016)

1297 Citations

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

Maria L. Agostini;Erica L. Andres;Amy C Sims;Rachel Lauren Graham.
Mbio (2018)

1129 Citations

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

Dustin Siegel;Hon C. Hui;Edward Doerffler;Michael O. Clarke.
Journal of Medicinal Chemistry (2017)

631 Citations

Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase

Allison A. Johnson;Adrian S. Ray;Jeremiah W. Hanes;Zucai Suo.
Journal of Biological Chemistry (2001)

458 Citations

Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine

Tomas Cihlar;Adrian S. Ray.
Antiviral Research (2010)

422 Citations

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses.

Michael K. Lo;Robert Jordan;Aaron Arvey;Jawahar Sudhamsu.
Scientific Reports (2017)

402 Citations

Mechanism of Active Renal Tubular Efflux of Tenofovir

Adrian S. Ray;Tomas Cihlar;Kelly L. Robinson;Leah Tong.
Antimicrobial Agents and Chemotherapy (2006)

368 Citations

Intracellular Metabolism and In Vitro Activity of Tenofovir against Hepatitis B Virus

William E. Delaney;Adrian S. Ray;Huiling Yang;Xiaoping Qi.
Antimicrobial Agents and Chemotherapy (2006)

279 Citations

Structural basis for RNA replication by the hepatitis C virus polymerase.

Todd C. Appleby;Jason K. Perry;Eisuke Murakami;Ona Barauskas.
Science (2015)

275 Citations

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