Adrian S. Ray

Overview

Best Publications

• Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

  Timothy P. Sheahan;Amy C. Sims;Rachel L. Graham;Vineet D. Menachery

  1740
  Citations

• Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

  Travis K. Warren;Robert Jordan;Michael K. Lo;Adrian S. Ray

  1641
  Citations

• Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

  Maria L. Agostini;Erica L. Andres;Amy C Sims;Rachel Lauren Graham

  1350
  Citations

• Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

  Dustin Siegel;Hon C. Hui;Edward Doerffler;Michael O. Clarke

  792
  Citations

• GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses.

  Michael K. Lo;Robert Jordan;Aaron Arvey;Jawahar Sudhamsu

  531
  Citations

• Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine

  Tomas Cihlar;Adrian S. Ray

  487
  Citations

• Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase

  Allison A. Johnson;Adrian S. Ray;Jeremiah W. Hanes;Zucai Suo

  471
  Citations

• Mechanism of Active Renal Tubular Efflux of Tenofovir

  Adrian S. Ray;Tomas Cihlar;Kelly L. Robinson;Leah Tong

  406
  Citations

• Tenofovir alafenamide: A novel prodrug of tenofovir for the treatment of Human Immunodeficiency Virus.

  Adrian S. Ray;Marshall W. Fordyce;Michael J.M. Hitchcock

  392
  Citations

• Structural basis for RNA replication by the hepatitis C virus polymerase.

  Todd C. Appleby;Jason K. Perry;Eisuke Murakami;Ona Barauskas

  342
  Citations

• Intracellular Metabolism and In Vitro Activity of Tenofovir against Hepatitis B Virus

  William E. Delaney;Adrian S. Ray;Huiling Yang;Xiaoping Qi

  322
  Citations

• Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma

  James S.V. Lally;Sarani Ghoshal;Danielle K. DePeralta;Omeed Moaven

  305
  Citations

• GS-0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease

  Rohit Loomba;Zeid Kayali;Mazen Noureddin;Peter Ruane

  288
  Citations

• Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents.

  Leigh Goedeke;Jamie Bates;Daniel F. Vatner;Rachel J. Perry

  242
  Citations

• Contribution of the organic anion transporter OAT2 to the renal active tubular secretion of creatinine and mechanism for serum creatinine elevations caused by cobicistat.

  Eve-Irene Lepist;Xuexiang Zhang;Jia Hao;Jane Huang

  239
  Citations

• Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides

  Aesop Cho;Oliver L. Saunders;Thomas Butler;Lijun Zhang

  234
  Citations

• Transporters in Drug Development: 2018 ITC Recommendations for Transporters of Emerging Clinical Importance

  Maciej J Zamek-Gliszczynski;Mitchell E Taub;Paresh P Chothe;Xiaoyan Chu

  215
  Citations

• Acetyl-CoA Carboxylase Inhibitor GS-0976 for 12 Weeks Reduces Hepatic De Novo Lipogenesis and Steatosis in Patients With Nonalcoholic Steatohepatitis.

  Eric J. Lawitz;Angie Coste;Fred Poordad;Naim Alkhouri

  185
  Citations

• Role of Purine Nucleoside Phosphorylase in Interactions between 2′,3′-Dideoxyinosine and Allopurinol, Ganciclovir, or Tenofovir

  Adrian S. Ray;Loren Olson;Arnold Fridland

  181
  Citations

• Implications of Efficient Hepatic Delivery by Tenofovir Alafenamide (GS-7340) for Hepatitis B Virus Therapy

  Eisuke Murakami;Ting Wang;Yeojin Park;Jia Hao

  177
  Citations