His main research concerns Virology, Prodrug, Polymerase, Nucleoside and Biochemistry. His Virology research includes themes of Resistance mutation and Drug discovery. His Prodrug study introduces a deeper knowledge of Pharmacology.
His Polymerase research is multidisciplinary, relying on both NS5B, Hepatitis C virus, Nucleoside analogue, Molecular biology and RNA polymerase. His Nucleoside research is multidisciplinary, incorporating perspectives in Aryl and Adenosine. His work deals with themes such as P-glycoprotein and Allopurinol, which intersect with Biochemistry.
Adrian S. Ray spends much of his time researching Pharmacology, Prodrug, Virology, Nucleoside and Biochemistry. His Pharmacology study combines topics in areas such as Peripheral blood mononuclear cell and Kidney metabolism. The study incorporates disciplines such as Oral administration, Phosphoramidate, Adenosine and Metabolite in addition to Prodrug.
His Virology research focuses on Virus, Ebola virus and Hepatitis C virus. His Nucleoside research includes elements of Phosphonate, Organic chemistry, Reverse transcriptase and Ribose. Adrian S. Ray focuses mostly in the field of Biochemistry, narrowing it down to topics relating to Molecular biology and, in certain cases, Mitochondrial toxicity.
Adrian S. Ray mostly deals with Pharmacology, Virology, Prodrug, Acetyl-CoA carboxylase and Ebola virus. His work carried out in the field of Pharmacology brings together such families of science as Mitochondrial toxicity, IC50 and Anti fibrotic. His Virology study focuses on Virus in particular.
His studies deal with areas such as Phosphoramidate, Peripheral blood mononuclear cell and Nucleoside as well as Prodrug. Adrian S. Ray combines subjects such as Amino acid, Oral administration, Adenosine, Nucleoside triphosphate and Efflux with his study of Nucleoside. His biological study spans a wide range of topics, including Nucleoside analogue, Proofreading and Viral load.
His primary areas of investigation include Virology, Lipogenesis, Ebola virus, Acetyl-CoA carboxylase and Nonalcoholic fatty liver disease. His study in the field of Viral replication and Viremia also crosses realms of Coronavirus. His biological study spans a wide range of topics, including Disease and Viral load.
His Ebola virus research integrates issues from Potency, Prodrug, Structure–activity relationship, Drug discovery and Viral shedding. His Prodrug research is multidisciplinary, incorporating perspectives in Marburgvirus, Ebolavirus, Adenosine and Nucleoside. His Nonalcoholic fatty liver disease research incorporates themes from Gastroenterology, Steatosis, Lipoprotein lipase and Fibrosis.
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Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
Timothy P. Sheahan;Amy C. Sims;Rachel L. Graham;Vineet D. Menachery.
Science Translational Medicine (2017)
Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys
Travis K. Warren;Robert Jordan;Michael K. Lo;Adrian S. Ray.
Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease
Maria L. Agostini;Erica L. Andres;Amy C Sims;Rachel Lauren Graham.
Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses
Dustin Siegel;Hon C. Hui;Edward Doerffler;Michael O. Clarke.
Journal of Medicinal Chemistry (2017)
Toxicity of Antiviral Nucleoside Analogs and the Human Mitochondrial DNA Polymerase
Allison A. Johnson;Adrian S. Ray;Jeremiah W. Hanes;Zucai Suo.
Journal of Biological Chemistry (2001)
Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine
Tomas Cihlar;Adrian S. Ray.
Antiviral Research (2010)
GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo-, and Paramyxoviruses.
Michael K. Lo;Robert Jordan;Aaron Arvey;Jawahar Sudhamsu.
Scientific Reports (2017)
Mechanism of Active Renal Tubular Efflux of Tenofovir
Adrian S. Ray;Tomas Cihlar;Kelly L. Robinson;Leah Tong.
Antimicrobial Agents and Chemotherapy (2006)
Intracellular Metabolism and In Vitro Activity of Tenofovir against Hepatitis B Virus
William E. Delaney;Adrian S. Ray;Huiling Yang;Xiaoping Qi.
Antimicrobial Agents and Chemotherapy (2006)
Structural basis for RNA replication by the hepatitis C virus polymerase.
Todd C. Appleby;Jason K. Perry;Eisuke Murakami;Ona Barauskas.
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