Ralph Hirschmann

Overview

Best Publications

• A new class of angiotensin-converting enzyme inhibitors

  Patchett Aa;Harris E;Tristram Ew;Wyvratt Mj

  982
  Citations

• A potent cyclic hexapeptide analogue of somatostatin

  Veber Df;Freidlinger Rm;Perlow Ds;Paleveda Wj

  585
  Citations

• Peptide synthesis catalyzed by an antibody containing a binding site for variable amino acids

  Ralph Hirschmann;Amos B. Smith;Carol M. Taylor;Patricia A. Benkovic

  451
  Citations

• Acetamidomethyl. A Novel Thiol Protecting Group for Cysteine

  Daniel Veber;John Milkowski;Sandor Varga;Robert Denkewalter

  425
  Citations

• Nonpeptidal peptidomimetics with a β-D-glucose scaffolding. A partial somatostatin agonist bearing a close structural relationship to a potent, selective substance P antagonist

  R. Hirschmann;K. C. Nicolaou;S. Pietranico;J. Salvino

  394
  Citations

• De novo design and synthesis of somatostatin non-peptide peptidomimetics utilizing beta-D-glucose as a novel scaffolding

  Ralph Hirschmann;K. C. Nicolaou;Sherrie Pietranico;Ellen M. Leahy

  390
  Citations

• Medicinal Chemistry in the Golden Age of Biology: Lessons from Steroid and Peptide Research

  Ralph Hirschmann

  290
  Citations

• Conformationally restricted bicyclic analogs of somatostatin.

  Daniel F. Veber;Frederick W. Holly;William J. Paleveda;Ruth F. Nutt

  219
  Citations

• Design, synthesis, and crystal structure of a pyrrolinone-based peptidomimetic possessing the conformation of a .beta.-strand: potential application to the design of novel inhibitors of proteolytic enzymes

  Amos B. Smith;Terence P. Keenan;Ryan C. Holcomb;Paul A. Sprengeler

  181
  Citations

• Studies on the total synthesis of an enzyme. V. The preparation of enzymatically active material.

  Ralph Hirschmann;Ruth F. Nutt;Daniel F. Veber;Ronald A. Vitali

  166
  Citations

• De Novo Design, Synthesis, and X-ray Crystal Structures of Pyrrolinone-Based .beta.-Strand Peptidomimetics

  Amos B. Smith;Mark C. Guzman;Paul A. Sprengeler;Terence P. Keenan

  152
  Citations

• Modulation of receptor and receptor subtype affinities using diastereomeric and enantiomeric monosaccharide scaffolds as a means to structural and biological diversity. A new route to ether synthesis.

  R. Hirschmann;J. Hynes;. M. A. Cichy-Knight;R. D. Van Rijn

  146
  Citations

• The Controlled Synthesis of Peptides in Aqueous Medium. I. The Use of α-Amino Acid N-Carboxyanhydrides

  Robert G. Denkewalter;H. Schwam;R. G. Strachan;Thomas E. Beesley

  140
  Citations

• The controlled synthesis of peptides in aqueous medium. 3. Use of Leuchs' anhydrides in the synthesis of dipeptides. Mechanism and control of side reactions.

  R Hirschmann;R G Strachan;H Schwam;E F Schoenewaldt

  130
  Citations

• Controlled synthesis of peptides in aqueous medium. VIII. Preparation and use of novel .alpha.-amino acid N-carboxyanhydrides

  Ralph Hirschmann;Harvey Schwam;R. G. Strachan;E. F. Schoenewaldt

  127
  Citations

• Pyrrolinone-Based Peptidomimetics: “Let the Enzyme or Receptor be the Judge”

  Amos B. Smith;Adam K. Charnley;Ralph Hirschmann

  126
  Citations

• The first design and synthesis of a steroidal peptidomimetic. The potential value of peptidomimetics in elucidating the bioactive conformation of peptide ligands

  Ralph Hirschmann;Paul A. Sprengeler;Tomomi Kawasaki;James W. Leahy

  118
  Citations

• Inferences about the conformation of somatostatin at a biologic receptor based on NMR studies

  Byron H. Arison;Ralph Hirschmann;Daniel F. Veber

  112
  Citations

• Heterocyclic analogues of the antihypertensive beta-adrenergic blocking agent (S)-2-[3-(ter-butylamino)-2-hydroxypropoxy]-3-cyanopyridine.

  John J. Baldwin;Edward L. Engelhardt;Ralph Hirschmann;Gerald S. Ponticello

  112
  Citations

• Peptide bond formation via catalytic antibodies: Synthesis of a novel phosphonate diester hapten

  Amos B. Smith;Amos B. Smith;Carol M. Taylor;Carol M. Taylor;Stephen J. Benkovic;Stephen J. Benkovic;Ralph Hirschmann;Ralph Hirschmann

  111
  Citations