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Chemistry

D-Index
50
Citations
9388
World Ranking
14343
National Ranking
3696

Research.com Recognitions

  • 2019 - Fellow of the American Chemical Society
  • 2017 - Perkin Medal, Society of Chemical Industry, American Section

Overview

Ann E. Weber is affiliated with MSD in the United States. Their research spans several fields predominantly within medicine, biochemistry, genetics, and molecular biology. Key subfields include endocrinology, diabetes and metabolism, cellular and molecular neuroscience, molecular medicine, infectious diseases, and epidemiology.

Weber has contributed to topics such as:

  • Diabetes treatment and management
  • Neuropeptides and animal physiology
  • Antibiotic resistance in bacteria
  • Tuberculosis research and epidemiology
  • Pneumocystis jirovecii pneumonia detection and treatment
  • Receptor mechanisms and signaling
  • Sex and gender in healthcare

Their recent publications include:

  • "Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates," 2022, Journal of Medicinal Chemistry
  • "Applying a gender lens to global health and well-being: Framing a Journal of Global Health special collection," 2020, Journal of Global Health
  • "Discovery of Gut-Targeted GPR40 Agonist K-757 and GPR119 Agonist K-833, a Combination Treatment for Metabolic Disorders," 2025, Journal of Medicinal Chemistry
  • "Dipeptidyl Peptidase 4 Inhibitors," 2021, Burger's Medicinal Chemistry and Drug Discovery
  • "A digital app-supported general practitioner-led weight loss program improves food literacy and intake in adults in rural Germany: Secondary outcomes of the HAPpEN pragmatic trial," 2025, bioRxiv (Cold Spring Harbor Laboratory)

Frequent co-authors working alongside Weber include:

  • Mihirbaran Mandal
  • Li Xiao
  • Weidong Pan
  • Giovanna Scapin
  • Guoqing Li

Common venues for Weber's work encompass:

  • Journal of Medicinal Chemistry
  • Journal of Global Health
  • Burger's Medicinal Chemistry and Drug Discovery
  • bioRxiv (Cold Spring Harbor Laboratory)

Weber has been recognized with awards including the Fellow of the American Chemical Society in 2019 and the Perkin Medal from the Society of Chemical Industry, American Section, in 2017.

Best Publications

  • (2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

    Dooseop Kim;Liping Wang;Maria Beconi;George J. Eiermann

  • Dipeptidyl Peptidase IV Inhibition for the Treatment of Type 2 Diabetes: Potential Importance of Selectivity Over Dipeptidyl Peptidases 8 and 9

    George R. Lankas;Barbara Leiting;Ranabir Sinha Roy;George J. Eiermann

  • Dipeptidyl peptidase IV inhibitors for the treatment of diabetes.

    Ann E Weber

  • Asymmetric glycine enolate aldol reactions: synthesis of cyclosporin's unusual amino acid, MeBmt

    David A. Evans;Ann E. Weber

  • Beta-amino heterocyclic dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

    Tesfaye Biftu;Gui-Bai Liang;Xiaoxia Qian;Ann E. Weber

  • Human β3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides

    Linda L Brockunier;Emma R Parmee;Hyun O Ok;Mari R Candelore

  • Synthesis of the cyclic hexapeptide echinocandin D. New approaches to the asymmetric synthesis of .beta.-hydroxy .alpha.-amino acids

    David A. Evans;Ann E. Weber

  • Discovery of JANUVIA (Sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

    Nancy A Thornberry;Ann E Weber

  • Omarigliptin (MK-3102): A Novel Long-Acting DPP-4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes.

    Tesfaye Biftu;Ranabir Sinha-Roy;Ping Chen;Xiaoxia Qian

  • Asymmetric synthesis of anti-β-hydroxy-α-amino acids

    David A. Evans;Eric B. Sjogren;Ann E. Weber;Robin E. Conn

  • Potent and selective human beta(3)-adrenergic receptor antagonists.

    Mari Rios Candelore;Liping Deng;Laurie Tota;Xiao-Ming Guan

  • (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]- pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.

    Edmondson Sd;Mastracchio A;Mathvink Rj;He J

  • Aminocyclohexanes as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes

    Tesfaye Biftu;Jason Cox;Danqing Feng;Anthony Mastracchio

  • Substituted piperazines as novel dipeptidyl peptidase IV inhibitors

    Linda L. Brockunier;Jiafang He;Lawrence F. Colwell;Bahanu Habulihaz

  • Dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

    Wallace T. Ashton;Charles G. Caldwell;Hyun O. Ok;Emma R. Parmee

  • Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors.

    Jinyou Xu;Hyun O. Ok;Edward J. Gonzalez;Lawrence F. Colwell

  • 3-amino-4-phenylbutanoic acid derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

    Wallace T. Ashton;Charles G. Caldwell;Robert J. Mathvink;Hyun O. Ok

  • Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors

    Scott D. Edmondson;Lan Wei;Jinyou Xu;Jackie Shang

  • A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice.

    Joel P. Berger;Ranabir SinhaRoy;Alessandro Pocai;Theresa M. Kelly

  • Discovery of Vibegron: A Potent and Selective β3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder

    Scott D. Edmondson;Cheng Zhu;Nam Fung Kar;Jerry Di Salvo

  • Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors.

    Charles G. Caldwell;Ping Chen;Jiafang He;Emma R. Parmee

  • Phenylalanine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes

    Joseph L. Duffy;Robert J. Mathvink;Ann E. Weber;Jinyou Xu

  • OXADIAZOLE BENZENESULFONAMIDES AS SELECTIVE -g(b) 3? AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY

    Tesfaye Biftu;Danqing Dennis Feng;Michael H Fisher;Chan-Hwa Kuo

Frequent Co-Authors

Michael H. Fisher
Michael H. Fisher MSD (United States)
Nancy A. Thornberry
Nancy A. Thornberry MSD (United States)
Malcolm Maccoss
Malcolm Maccoss MSD (United States)
Giovanna Scapin
Giovanna Scapin MSD (United States)
Matthew J. Wyvratt
Matthew J. Wyvratt Medicines for Malaria Venture
Margaret A. Cascieri
Margaret A. Cascieri MSD (United States)
Catherine D. Strader
Catherine D. Strader MSD (United States)
Arthur A. Patchett
Arthur A. Patchett MSD (United States)
William J. Greenlee
William J. Greenlee MSD (United States)
David A. Evans
David A. Evans Harvard University

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