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William J. Greenlee

William J. Greenlee

D-Index & Metrics

Chemistry

D-Index
60
Citations
12954
World Ranking
9688
National Ranking
2724

Research.com Recognitions

  • 2009 - Fellow of the American Chemical Society
  • 2007 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

William J. Greenlee is affiliated with MSD in the United States and has contributed to research primarily in the field of Biochemistry, Genetics and Molecular Biology. Their work spans several subfields including Molecular Biology, Organic Chemistry, Hematology, Materials Chemistry, and Cell Biology.

Their research topics include:

  • Blood Coagulation and Thrombosis Mechanisms
  • Click Chemistry and Applications
  • Aldose Reductase and Taurine
  • Cardiac Ischemia and Reperfusion
  • Heme Oxygenase-1 and Carbon Monoxide
  • Glycosylation and Glycoproteins Research
  • Carbohydrate Chemistry and Synthesis

William J. Greenlee has multiple publications with several notable research contributions:

  • Identification of a Selective SCoR2 Inhibitor That Protects Against Acute Kidney Injury, 2023, Journal of Medicinal Chemistry
  • Exploring the inhibition of the soluble lytic transglycosylase Cj0843c of Campylobacter jejuni via targeting different sites with different scaffolds, 2023, Protein Science
  • Discovery of hydroxy pyrimidine Factor IXa inhibitors, 2020, Bioorganic & Medicinal Chemistry Letters
  • CCDC 2476870: Experimental Crystal Structure Determination, 2025, The Cambridge Structural Database
  • Impact of COVID-19 on ACS finances, 2020, C&EN Global Enterprise

Frequent co-authors in their work include:

  • Focco van den Akker
  • Zhuyan Guo
  • Matthew J. Wyvratt
  • Hua-Lin Zhou
  • Alfred Hausladen

The venues where William J. Greenlee has regularly published research are:

  • Journal of Medicinal Chemistry
  • Protein Science
  • Bioorganic & Medicinal Chemistry Letters
  • The Cambridge Structural Database
  • C&EN Global Enterprise

William J. Greenlee has been recognized by professional societies with awards including:

  • Fellow of the American Chemical Society, 2009
  • Fellow of the American Association for the Advancement of Science (AAAS), 2007

Best Publications

  • A new class of angiotensin-converting enzyme inhibitors

    Patchett Aa;Harris E;Tristram Ew;Wyvratt Mj

  • SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo.

    Julie M. Strizki;Serena Xu;Nicole E. Wagner;Lisa Wojcik

  • Nonpeptide Angiotensin II Receptor Antagonists: The Next Generation in Antihypertensive Therapy

    Ruth R. Wexler;William J. Greenlee;John D. Irvin;Michael R. Goldberg

  • Discovery of a novel, orally active himbacine-based thrombin receptor antagonist (SCH 530348) with potent antiplatelet activity.

    Samuel Chackalamannil;Yuguang Wang;William J. Greenlee;Zhiyong Hu

  • 5-Chloro-3-(phenylsulfonyl)indole-2-carboxamide: a novel, non-nucleoside inhibitor of HIV-1 reverse transcriptase

    T M Williams;T M Ciccarone;S C MacTough;C S Rooney

  • Substituted imidazo-fused 6-membered heterocycles as angiotensin ii antagonists

    Prasun K. Chakravarty;William J. Greenlee;Nathan B. Mantlo;Arthur A. Patchett

  • Heterocyclic aspartyl protease inhibitors

    Zhaoning Zhu;Brian McKittrick;Zhong-Yue Sun;Yuanzan C. Ye

  • Identification of peptide binding residues in the extracellular domains of the AT1 receptor.

    S A Hjorth;H T Schambye;W J Greenlee;T W Schwartz

  • Discovery of the 3-Imino-1,2,4-thiadiazinane 1,1-Dioxide Derivative Verubecestat (MK-8931)–A β-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibitor for the Treatment of Alzheimer’s Disease

    Jack D. Scott;Sarah W. Li;Andrew P. J. Brunskill;Xia Chen

  • Discovery of Cyclic Acylguanidines as Highly Potent and Selective beta-Site Amyloid Cleaving Enzyme (BACE) Inhibitors: Part I-Inhibitor Design and Validation

    Zhaoning Zhu;Zhong-Yue Sun;Yuanzan Ye;Johannes Voigt

  • Structure based design of iminohydantoin BACE1 inhibitors: Identification of an orally available, centrally active BACE1 inhibitor.

    Jared N. Cumming;Elizabeth M. Smith;Lingyan Wang;Jeffrey Misiaszek

  • Potent, selective, and orally active adenosine A2A receptor antagonists: arylpiperazine derivatives of pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines.

    Bernard R. Neustadt;Jinsong Hao;Neil Lindo;William J. Greenlee

  • Total synthesis of cytochalasin B

    Gilbert Stork;Yoshiaki Nakahara;Yuko Nakahara;W. J. Greenlee

  • Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells.

    R Saperstein;P P Vicario;H V Strout;E Brady

  • Discovery of 4-[(Z)-(4-bromophenyl)- (ethoxyimino)methyl]-1'-[(2,4-dimethyl-3- pyridinyl)carbonyl]-4'-methyl-1,4'- bipiperidine N-oxide (SCH 351125): an orally bioavailable human CCR5 antagonist for the treatment of HIV infection.

    Anandan Palani;Sherry Shapiro;John W. Clader;William J. Greenlee

  • Discovery of Potent Orally Active Thrombin Receptor (Protease Activated Receptor 1) Antagonists as Novel Antithrombotic Agents

    Samuel Chackalamannil;Yan Xia;William J Greenlee;Martin Clasby

  • Substituted quinazolinones as angiotensin II antagonists.

    Eric E Allen;Laszlo Stephen E De;William J Greenlee;Arthur A Patchett

  • Application of Fragment-Based NMR Screening, X-ray Crystallography, Structure-Based Design, and Focused Chemical Library Design to Identify Novel μM Leads for the Development of nM BACE-1 (β-Site APP Cleaving Enzyme 1) Inhibitors

    Yu-Sen Wang;Corey Strickland;Johannes H Voigt;Matthew E Kennedy

  • In vitro pharmacology of L-158,809, a new highly potent and selective angiotensin II receptor antagonist.

    R. S. L. Chang;P. K. S. Siegl;B. V. Clineschmidt;N. B. Mantlo

  • A potent, orally active, balanced affinity angiotensin II AT1 antagonist and AT2 binding inhibitor.

    S E de Laszlo;C S Quagliato;W J Greenlee;A A Patchett

Frequent Co-Authors

Arthur A. Patchett
Arthur A. Patchett MSD (United States)
Malcolm Maccoss
Malcolm Maccoss MSD (United States)
Ann E. Weber
Ann E. Weber MSD (United States)

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