What is he best known for?
The fields of study he is best known for:
- Enzyme
- Organic chemistry
- Amino acid
Kevin T. Chapman spends much of his time researching Enzyme, Biochemistry, Organic chemistry, Pharmacology and Internal medicine.
His Enzyme research includes themes of Matrix metalloproteinase, Stereochemistry and Peptide.
Kevin T. Chapman integrates several fields in his works, including Biochemistry and Brush border.
His work in Organic chemistry addresses issues such as Solid-phase synthesis, which are connected to fields such as Primary, Urea and Yield.
Kevin T. Chapman combines subjects such as Oligopeptide, Caspase 1, Protein structure and Caspase 4 with his study of Cysteine protease.
His Caspase research integrates issues from Granzyme B and Cell biology.
His most cited work include:
- A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes. (2141 citations)
- A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B FUNCTIONAL RELATIONSHIPS ESTABLISHED FOR KEY MEDIATORS OF APOPTOSIS (1880 citations)
- The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1). (607 citations)
What are the main themes of his work throughout his whole career to date?
The scientist’s investigation covers issues in Biochemistry, Stereochemistry, Enzyme, Enzyme inhibitor and Chemical synthesis.
His Pharmacology research extends to the thematically linked field of Biochemistry.
His work on Moiety as part of general Stereochemistry study is frequently connected to Selectivity, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them.
Kevin T. Chapman focuses mostly in the field of Enzyme, narrowing it down to topics relating to Interleukin 1β converting enzyme and, in certain cases, Aspartic acid.
The Enzyme inhibitor study combines topics in areas such as Potency and Peptide.
His study in Chemical synthesis is interdisciplinary in nature, drawing from both Pyrrolidine, Piperidine, Antagonist and Carboxamide.
He most often published in these fields:
- Biochemistry (30.83%)
- Stereochemistry (30.00%)
- Enzyme (27.50%)
What were the highlights of his more recent work (between 2005-2015)?
- Biochemistry (30.83%)
- Enzyme (27.50%)
- Pharmacology (11.67%)
In recent papers he was focusing on the following fields of study:
His scientific interests lie mostly in Biochemistry, Enzyme, Pharmacology, In vitro and Stereochemistry.
His research on Biochemistry focuses in particular on Antagonist.
His work on Enzyme inhibitor as part of his general Enzyme study is frequently connected to MRNA cleavage and Polyadenylation, thereby bridging the divide between different branches of science.
Many of his research projects under Pharmacology are closely connected to RNA interference with RNA interference, tying the diverse disciplines of science together.
His In vitro research includes elements of Tumor necrosis factor alpha and Protein kinase A.
His Stereochemistry study incorporates themes from hERG, Mechanism of action, Polymerase and Amide.
Between 2005 and 2015, his most popular works were:
- TRPM8 activation attenuates inflammatory responses in mouse models of colitis (94 citations)
- The discovery of a potent and selective lethal factor inhibitor for adjunct therapy of anthrax infection. (55 citations)
- 1,3,8-Triazaspiro[4.5]decane-2,4-diones as efficacious pan-inhibitors of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) for the treatment of anemia. (39 citations)
In his most recent research, the most cited papers focused on:
- Enzyme
- Organic chemistry
- Amino acid
Kevin T. Chapman mainly focuses on Biochemistry, Enzyme, Structure–activity relationship, Pharmacology and Peptide hormone.
His Enzyme research is multidisciplinary, relying on both Decane, Anemia and Potassium channel.
His research in Structure–activity relationship intersects with topics in Microbiology, IC50, Cytotoxicity, High-throughput screening and Bacillus anthracis.
His biological study spans a wide range of topics, including Acetamide, Colitis, Antibacterial agent, Inflammation and TRPV1.
His Peptide hormone research incorporates elements of Oral administration, Antagonist, Glucagon and Pyrazole.
His Oral administration study frequently draws connections between related disciplines such as Glucagon receptor.
This overview was generated by a machine learning system which analysed the scientist’s
body of work. If you have any feedback, you can
contact us
here.
