World's Best Scientists 2026 revealed!

Overview

Jeffrey J. Hale is affiliated with MSD in the United States. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with notable focuses on Infectious Diseases, Immunology, Public Health, Environmental and Occupational Health, Virology, and Molecular Biology.

Their main research topics cover:

  • interferon and immune responses
  • Viral Infections and Vectors
  • Mosquito-borne diseases and control
  • HIV/AIDS drug development and treatment
  • HIV Research and Treatment
  • Biochemical and Molecular Research

Recent scholarly publications by Hale include:

  • "Nitrofuran-Based STING Inhibitors," published in 2025 in ACS Omega
  • "MK-8527 is a novel inhibitor of HIV-1 reverse transcriptase translocation with potential for extended-duration dosing," published in 2025 in PLoS Biology

Frequent co-authors collaborating with Hale are:

  • Leonard Barasa
  • Leo DeOrsey
  • Maeve O'Reilly
  • Shruti Choudhary
  • Sara Cahill

The primary venues where Hale's work has appeared include:

  • ACS Omega
  • PLoS Biology

Best Publications

  • Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.

    Suzanne Mandala;Richard Hajdu;James Bergstrom;Elizabeth Quackenbush

  • Distinct Mechanism for Antidepressant Activity by Blockade of Central Substance P Receptors

    Mark S. Kramer;Neal Cutler;John Feighner;Ram Shrivastava

  • Immune Cell Regulation and Cardiovascular Effects of Sphingosine 1-Phosphate Receptor Agonists in Rodents Are Mediated via Distinct Receptor Subtypes

    M. Forrest;S.-Y. Sun;R. Hajdu;J. Bergstrom

  • Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

    J. J. Hale;S. G. Mills;M. Maccoss;P. E. Finke

  • Morpholine and thiomorpholine tachykinin receptor antagonists

    Conrad P. Dorn;Paul E. Finke;Jeffrey J. Hale;Malcolm MacCoss

  • Pyrrolidine modulators of chemokine receptor activity

    Charles Caldwell;Kevin T. Chapman;Jeffrey Hale;Dooseop Kim

  • Selective s1p1/edg1 receptor agonists

    George A. Doherty;Michael J. Forrest;Richard Hajdu;Jeffrey J. Hale

  • Edg receptor agonists

    Robert L. Bugianesi;George A. Doherty;Amy Gentry;Jeffrey J. Hale

  • Pyrrolidine and piperidine modulators of chemokine receptor activity

    Richard J. Budhu;Jeffrey J. Hale;Edward Holson;Christopher Lynch

  • Potent 1,3,4-trisubstituted pyrrolidine CCR5 receptor antagonists: effects of fused heterocycles on antiviral activity and pharmacokinetic properties.

    Dooseop Kim;Liping Wang;Jeffrey J. Hale;Christopher L. Lynch

  • The novel NK1 receptor antagonist MK–0869 (L–754,030) and its water soluble phosphoryl prodrug, L–758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets

    F.D Tattersall;W Rycroft;M Cumberbatch;G Mason

  • (3,4-disubstituted)propanoic carboxylates as s1p (edg) receptor agonists

    Vincent J. Colandrea;George A. Doherty;Jeffrey J. Hale;Pei Huo

  • Discovery of Potent 3,5-Diphenyl-1,2,4-oxadiazole Sphingosine-1-phosphate-1 (S1P1) Receptor Agonists with Exceptional Selectivity against S1P2 and S1P3

    Zhen Li;Weirong Chen;Jeffrey J Hale;Christopher L Lynch

  • Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720

    Jeffrey J. Hale;William Neway;Sander G. Mills;Richard Hajdu

  • N-(benzyl)aminoalkylcarboxylates, phosphinates, phosphonates and tetrazoles as edg receptor agonists

    George A. Doherty;Zhen Li;Jeffrey J. Hale;Sander G. Mills

  • A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists.

    Jeffrey J. Hale;Christopher L. Lynch;William Neway;Sander G. Mills

  • In vitro and in vivo predictors of the anti-emetic activity of tachykinin NK1 receptor antagonists

    Nadia M.J. Rupniak;F.David Tattersall;Angela R. Williams;Wayne Rycroft

  • 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists

    Weirong Chen;Jeffrey J. Hale;Zhen Li;Christopher L. Lynch

  • 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists

    Vincent J. Colandrea;George A. Doherty;Jeffrey J. Hale;Christopher Lynch

  • 3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists

    George A. Doherty;Jeffrey J. Hale;Irene E. Legiec;Christopher L. Lynch

Frequent Co-Authors

Sander G. Mills
Sander G. Mills MSD (United States)
Malcolm Maccoss
Malcolm Maccoss MSD (United States)
Daria J. Hazuda
Daria J. Hazuda MSD (United States)
Hugh Rosen
Hugh Rosen Scripps Research Institute
Kevin T. Chapman
Kevin T. Chapman MSD (United States)
Michael W. Miller
Michael W. Miller MSD (United States)
Margaret A. Cascieri
Margaret A. Cascieri MSD (United States)
Edward M. Scolnick
Edward M. Scolnick Broad Institute
Hong C. Shen
Hong C. Shen Roche (Switzerland)

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