World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
41
Citations
6587
World Ranking
17749
National Ranking
294

Overview

Hong C. Shen is affiliated with Roche (Switzerland) and has contributed extensively to research in medicine and chemistry. Their work spans multiple areas including organic chemistry, molecular biology, oncology, epidemiology, and immunology.

Their research topics notably cover:

  • Synthesis and Catalytic Reactions
  • Catalytic C-H Functionalization Methods
  • Hepatitis B Virus Studies
  • Hepatitis C virus research
  • Cytokine Signaling Pathways and Interactions
  • Interferon and Immune Responses
  • Sulfur-Based Synthesis Techniques

Shen has published in several scientific journals, with frequent contributions to:

  • Journal of Medicinal Chemistry (6 publications)
  • Bioorganic & Medicinal Chemistry Letters (4 publications)
  • SSRN Electronic Journal (3 publications)
  • Cell (1 publication)
  • Cell Reports (1 publication)

Recent selected publications include:

  • Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation, 2020, Cell
  • Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling, 2020, Cell Reports
  • Discovery of Pyrido[2,3-b]indole Derivatives with Gram-Negative Activity Targeting Both DNA Gyrase and Topoisomerase IV, 2020, Journal of Medicinal Chemistry
  • A synthetic STING agonist inhibits the replication of human parainfluenza virus 3 and rhinovirus 16 through distinct mechanisms, 2020, Antiviral Research
  • Small molecule approaches to treat autoimmune and inflammatory diseases (Part III): Targeting cytokines and cytokine receptor complexes, 2021, Bioorganic & Medicinal Chemistry Letters

Collaborations form an important part of Shen's work. Frequent co-authors include:

  • Xuefei Tan
  • Wei Zhu
  • Jun Wu
  • Xiao Ding
  • Fabian Dey

Overall, Hong C. Shen's expertise spans foundational and applied aspects within organic chemistry and medicine, with an emphasis on viral infections, immune signaling, and synthetic methods relevant to drug discovery and development.

Best Publications

  • Recent advances in syntheses of heterocycles and carbocycles via homogeneous gold catalysis. Part 1: Heteroatom addition and hydroarylation reactions of alkynes, allenes, and alkenes

    Hong C. Shen

  • Recent advances in syntheses of carbocycles and heterocycles via homogeneous gold catalysis. Part 2: Cyclizations and cycloadditions

    Hong C. Shen

  • Discovery of inhibitors of soluble epoxide hydrolase: a target with multiple potential therapeutic indications.

    Hong C. Shen;Bruce D. Hammock

  • Ruthenium-Catalyzed Intramolecular [5 + 2] Cycloadditions

    Barry M. Trost;and F. Dean Toste;Hong Shen

  • Asymmetric synthesis of chiral chromans

    Hong C. Shen

  • Synthesis of chiral chromans by the Pd-catalyzed asymmetric allylic alkylation (AAA): scope, mechanism, and applications.

    Barry M Trost;Hong C Shen;Li Dong;Jean-Philippe Surivet

  • Palladium-Catalyzed Suzuki−Miyaura Coupling of Pyridyl-2-boronic Esters with Aryl Halides Using Highly Active and Air-Stable Phosphine Chloride and Oxide Ligands

    David X. Yang;Steven L. Colletti;Kevin Wu;Maoying Song

  • Syntheses of Seven-Membered Rings: Ruthenium-Catalyzed Intramolecular [5+2] Cycloadditions

    Barry M. Trost;Hong C. Shen;Daniel B. Horne;F. Dean Toste

  • Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling.

    Jeffrey K. Holden;James J. Crawford;Cameron L. Noland;Stephen Schmidt

  • Unusual Effects in the Pd-Catalyzed Asymmetric Allylic Alkylations: Synthesis of Chiral Chromans

    Barry M. Trost;Hong C. Shen;Li Dong;Jean-Philippe Surivet

  • Heteroaryldihydropyrimidine (HAP) and Sulfamoylbenzamide (SBA) Inhibit Hepatitis B Virus Replication by Different Molecular Mechanisms.

    Zheng Zhou;Taishan Hu;Xue Zhou;Steffen Wildum

  • 6-bridged heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis B virus infection

    Lei Guo;Taishan Hu;Yimin Hu;Buelent Kocer

  • Constructing Tricyclic Compounds Containing a Seven‐Membered Ring by Ruthenium‐Catalyzed Intramolecular [5+2] Cycloaddition

    Barry M. Trost;Hong C. Shen

  • Biomimetic enantioselective total synthesis of (-)-siccanin via the Pd-catalyzed asymmetric allylic alkylation (AAA) and sequential radical cyclizations.

    Barry M. Trost;Hong C. Shen;Jean-Philippe Surivet

  • An Enantioselective Biomimetic Total Synthesis of (−)-Siccanin

    Barry M. Trost;Hong C. Shen;Jean-Philippe Surivet

  • Soluble epoxide hydrolase inhibitors: a patent review.

    Hong C Shen

  • Discovery of Imidazopyridine Derivatives as Highly Potent Respiratory Syncytial Virus Fusion Inhibitors

    Song Feng;Di Hong;Baoxia Wang;Xiufang Zheng

  • Sequential 1,2-Addition−Electrocyclic Ring Closures Involving Acyclic α,β-Unsaturated Iminiums: A Formal [3 + 3] Cycloaddition Strategy to Unique Pyranyl Spirocycles

    Richard P. Hsung;Hong C. Shen;Christopher J. Douglas;Christopher D. Morgan

  • A Formal [3 + 3] Cycloaddition Reaction. Improved Reactivity Using α,β-Unsaturated Iminium Salts and Evidence for Reversibility of 6π-Electron Electrocyclic Ring Closure of 1-Oxatrienes

    Hong C. Shen;Jiashi Wang;Kevin P. Cole;Michael J. McLaughlin

  • On the regioselectivity of the Ru-catalyzed intramolecular [5 + 2] cycloaddition.

    Barry M. Trost;Hong C. Shen

  • Gold(I)-Catalyzed Regioselective Cyclizations of Silyl Ketene Amides and Carbamates with Alkynes

    Ellen C. Minnihan;Steven L. Colletti;F. Dean Toste;Hong C. Shen

Frequent Co-Authors

Barry M. Trost
Barry M. Trost Stanford University
Richard P. Hsung
Richard P. Hsung University of Wisconsin–Madison
Andrei S. Batsanov
Andrei S. Batsanov Durham University
Andrew Whiting
Andrew Whiting Durham University
Xuhong Qian
Xuhong Qian East China University of Science and Technology
F. Dean Toste
F. Dean Toste University of California, Berkeley
Sophie Roy
Sophie Roy MSD (United States)
Jeffrey J. Hale
Jeffrey J. Hale MSD (United States)
Yu-Cheng Gu
Yu-Cheng Gu Syngenta (Switzerland)
Sheo B. Singh
Sheo B. Singh MSD (United States)

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