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D-Index & Metrics

Molecular Biology

D-Index
56
Citations
9045
World Ranking
2225
National Ranking
50

Overview

Sergio Ottolenghi is affiliated with the University of Milano-Bicocca in Italy. Their research primarily focuses on biochemistry, genetics, and molecular biology, with additional contributions to medicine. Within these domains, their work extends into specialized subfields including molecular biology, cancer research, cellular and molecular neuroscience, oncology, and genetics.

The scientist's main research topics cover diverse areas such as pluripotent stem cells research, RNA research and splicing, microRNA in disease regulation, CRISPR and genetic engineering, cancer cells and metastasis, retinal development and disorders, and axon guidance and neuronal signaling.

Key recent publications include:

  • Sox2 Controls Neural Stem Cell Self-Renewal Through a Fos-Centered Gene Regulatory Network, 2021, Stem Cells
  • FOS Rescues Neuronal Differentiation of Sox2-Deleted Neural Stem Cells by Genome-Wide Regulation of Common SOX2 and AP1(FOS-JUN) Target Genes, 2021, Cells
  • Sox2 controls neural stem cell self-renewal through a Fos-centered gene regulatory network, 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • Sox2-dependent maintenance of mouse oligodendroglioma involves the Sox2-mediated downregulation of Cdkn2b, Ebf1, Zfp423, and Hey2, 2020, Glia
  • The Coup-TFII orphan nuclear receptor is an activator of the γ-globin gene, 2020, Haematologica

The frequent co-authors contributing to their research include Silvia K. Nicolis, Claudio Cantù, Miriam Pagin, Giulio Pavesi, and Cristiana Barone. Their work has been published repeatedly in the venues bioRxiv (Cold Spring Harbor Laboratory), Stem Cells, Cells, Glia, and Haematologica.

Best Publications

  • Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain.

    Anna L. M. Ferri;Maurizio Cavallaro;Daniela Braida;Antonello Di Cristofano

  • Adult c-kitpos Cardiac Stem Cells Are Necessary and Sufficient for Functional Cardiac Regeneration and Repair

    Georgina M. Ellison;Carla Vicinanza;Carla Vicinanza;Andrew J. Smith;Iolanda Aquila

  • Hippocampal development and neural stem cell maintenance require Sox2-dependent regulation of Shh

    Rebecca Favaro;Menella Valotta;Anna L M Ferri;Elisa Latorre

  • Sox2 regulatory sequences direct expression of a (beta)-geo transgene to telencephalic neural stem cells and precursors of the mouse embryo, revealing regionalization of gene expression in CNS stem cells.

    M.V. Zappone;R. Galli;R. Catena;N. Meani

  • Stem cell-mediated muscle regeneration is enhanced by local isoform of insulin-like growth factor 1

    Antonio Musarò;Cristina Giacinti;Giovanna Borsellino;Gabriella Dobrowolny

  • The severe form of alpha thalassaemia is caused by a haemoglobin gene deletion.

    Ottolenghi S;Lanyon Wg;Paul J;Williamson R

  • Impaired generation of mature neurons by neural stem cells from hypomorphic Sox2 mutants

    Maurizio Cavallaro;Jessica Mariani;Cesare Lancini;Elisa Latorre

  • Repression of kit expression by Plzf in germ cells.

    Doria Filipponi;Robin M. Hobbs;Sergio Ottolenghi;Pellegrino Rossi

  • The "Bystander Effect": Association of U-87 Cell Death With Ganciclovir-Mediated Apoptosis of Nearby Cells and Lack of Effect in Athymic Mice

    Bruno M. Colombo;Sara Benedetti;Sergio Ottolenghi;Marina Mora

  • Conserved POU binding DNA sites in the Sox2 upstream enhancer regulate gene expression in embryonic and neural stem cells.

    Raffaella Catena;Cecilia Tiveron;Antonella Ronchi;Silvia Porta

  • Evolution of the c-kit-Positive Cell Response to Pathological Challenge in the Myocardium

    Jenna Fransioli;Brandi Bailey;Natalie A. Gude;Christopher T. Cottage

  • Human globin chain separation by isolectric focusing

    Pier Giorgio Righetti;Elisabetta Gianazza;Alessandro M. Gianni;Paola Comi

  • The deletion in a type of delta 0-beta 0-thalassaemia begins in an inverted AluI repeat.

    Sergio Ottolenghi;Barbara Giglioni

  • Distamycins inhibit the binding of OTF-1 and NFE-1 transfactors to their conserved DNA elements

    Massimo Broggini;Mauro Ponti;Sergio Ottolenghi;Maurizio D'Incalci

  • Cardiomyogenesis in the Developing Heart Is Regulated by C-Kit–Positive Cardiac Stem Cells

    João Ferreira-Martins;Barbara Ogórek;Donato Cappetta;Alex Matsuda

  • Delta-beta-thalassemia is due to a gene deletion.

    S. Ottolenghi;P. Comi;B. Giglioni;P. Tolstoshev

  • UFD1L, a Developmentally Expressed Ubiquitination Gene, is Deleted in CATCH 22 Syndrome

    Antonio Pizzuti;Giuseppe Novelli;Antonia Ratti;Francesca Amati

  • SOHLH1 and SOHLH2 control Kit expression during postnatal male germ cell development.

    Florencia Barrios;Doria Filipponi;Federica Campolo;Manuele Gori

  • Acetylation and MAPK phosphorylation cooperate to regulate the degradation of active GATA-1

    Angel Hernandez-Hernandez;Pampa Ray;Gabi Litos;Marco Ciro

  • The effects of HPFH mutations in the human γ-globin promoter on binding of ubiquitous and erythroid specific nuclear factors

    R. Mantovani;N. Malgaretti;S. Nicolis;A. Ronchi

Frequent Co-Authors

Silvia K. Nicolis
Silvia K. Nicolis University of Milano-Bicocca
Anna Rita Migliaccio
Anna Rita Migliaccio University of Bologna
Giovanni Migliaccio
Giovanni Migliaccio University of Washington
Roberto Mantovani
Roberto Mantovani University of Milan
Giuseppe Saglio
Giuseppe Saglio University of Turin
Clara Camaschella
Clara Camaschella Vita-Salute San Raffaele University
Cesare Peschle
Cesare Peschle Istituto Superiore di Sanità
Robert Williamson
Robert Williamson University of Melbourne
Masayuki Yamamoto
Masayuki Yamamoto Tohoku University
David J. Weatherall
David J. Weatherall University of Oxford

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