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Genetics

D-Index
46
Citations
10518
World Ranking
4152
National Ranking
471

Overview

Grant S. Stewart is affiliated with the University of Birmingham in the United Kingdom. Their research spans multiple fields primarily within Biochemistry, Genetics and Molecular Biology, complemented by substantial contributions to Medicine. Specifically, their work engages deeply with subfields such as Molecular Biology, Oncology, Cell Biology, Genetics, and Pulmonary and Respiratory Medicine.

The topics central to Stewart's research focus on mechanisms and pathways related to DNA and cellular processes. Notable areas include DNA Repair Mechanisms, Microtubule and mitosis dynamics, Genomics and Chromatin Dynamics, CRISPR and Genetic Engineering, Ubiquitin and proteasome pathways, Renal cell carcinoma treatment, and PARP inhibition in cancer therapy.

Stewart has a significant body of published work with frequent appearance in leading scientific journals. The primary venues for their publications include Nature Communications, bioRxiv (Cold Spring Harbor Laboratory), Nucleic Acids Research, The Journal of Urology, and the Journal of Clinical Investigation.

Major papers authored or co-authored by Stewart include:

  • Warsaw Breakage Syndrome associated DDX11 helicase resolves G-quadruplex structures to support sister chromatid cohesion, 2020, Nature Communications
  • DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain, 2020, Nature Communications
  • Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair, 2021, Nature Communications
  • The structural mechanism of dimeric DONSON in replicative helicase activation, 2023, Molecular Cell
  • Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening, 2021, Nature Communications

Throughout their career, Stewart has collaborated extensively with several co-authors, most frequently with Satpal S. Jhujh, John J. Reynolds, Gavin S. McNee, Robert M. Hollingworth, and Martin R. Higgs, indicating a broad network of scientific collaboration.

Best Publications

  • The DNA Double-Strand Break Repair Gene hMRE11 Is Mutated in Individuals with an Ataxia-Telangiectasia-like Disorder

    Grant S Stewart;Richard S Maser;Tanja Stankovic;Debra A Bressan

  • MDC1 is a mediator of the mammalian DNA damage checkpoint

    Grant S. Stewart;Bin Wang;Colin R. Bignell;A. Malcolm R. Taylor

  • The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage

    Grant S. Stewart;Stephanie Panier;Stephanie Panier;Kelly Townsend;Abdallah K. Al-Hakim

  • Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia

    Tatjana Stankovic;Peter Weber;Grant Stewart;Tina Bedenham

  • 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

    Angela T Noon;Atsushi Shibata;Nicole Rief;Markus Lobrich

  • p53 dysfunction in B-cell chronic lymphocytic leukemia: inactivation of ATM as an alternative to TP53 mutation.

    Andrew R. Pettitt;Paul D. Sherrington;Grant Stewart;John C. Cawley

  • Constitutive phosphorylation of MDC1 physically links the MRE11–RAD50–NBS1 complex to damaged chromatin

    Christoph Spycher;Edward S. Miller;Kelly Townsend;Lucijana Pavic

  • ATR inhibition induces synthetic lethality and overcomes chemoresistance in TP53- or ATM-defective chronic lymphocytic leukemia cells

    Marwan Kwok;Marwan Kwok;Nicholas Davies;Angelo Agathanggelou;Edward Smith

  • A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses

    Caroline E Lilley;Mira S Chaurushiya;Mira S Chaurushiya;Chris Boutell;Sebastien Landry

  • Chromosome instability syndromes

    A. Malcolm R. Taylor;Cynthia Rothblum-Oviatt;Nathan A. Ellis;Ian D. Hickson

  • Regulation of DNA-End Resection by hnRNPU-like Proteins Promotes DNA Double-Strand Break Signaling and Repair

    Sophie E. Polo;Andrew N. Blackford;J. Ross Chapman;Linda Baskcomb

  • RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling

    Grant S. Stewart;Tatjana Stankovic;Philip J. Byrd;Thomas Wechsler

  • Ataxia telangiectasia mutated-deficient B-cell chronic lymphocytic leukemia occurs in pregerminal center cells and results in defective damage response and unrepaired chromosome damage.

    Tatjana Stankovic;Grant S. Stewart;Christopher Fegan;Paul Biggs

  • BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks.

    Martin R. Higgs;John J. Reynolds;Alicja Winczura;Andrew N. Blackford

  • Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation

    Shiaw Yih Lin;Kaiyi Li;Grant S. Stewart;Stephen J. Elledge;Stephen J. Elledge

  • PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation.

    George E. Ronson;Ann Liza Piberger;Martin R. Higgs;Anna L. Olsen

  • The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol η in response to oxidative DNA damage in human cells

    Anastasia Zlatanou;Emmanuelle Despras;Tirzah Braz-Petta;Imenne Boubakour-Azzouz

  • Microarray analysis reveals that TP53- and ATM-mutant B-CLLs share a defect in activating proapoptotic responses after DNA damage but are distinguished by major differences in activating prosurvival responses.

    Tatjana Stankovic;Mike Hubank;Debbie Cronin;Grant S. Stewart

  • PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination

    Thomas L. Clarke;Maria Pilar Sanchez-Bailon;Kelly Chiang;John J. Reynolds

  • The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression

    Andrew S. Turnell;Grant S. Stewart;Grant S. Stewart;Roger J. A. Grand;Susan M. Rookes

Frequent Co-Authors

Paul Moss
Paul Moss University of Birmingham
J J Reynolds
J J Reynolds King's College London
Andrew P. Jackson
Andrew P. Jackson University of Edinburgh
Stephen J. Elledge
Stephen J. Elledge Harvard University
Thomas Dobner
Thomas Dobner Heinrich-Pette-Institute
Daniel Durocher
Daniel Durocher Lunenfeld-Tanenbaum Research Institute
Razqallah Hakem
Razqallah Hakem University of Toronto
Christopher G. Mathew
Christopher G. Mathew King's College London
Stephen P. Jackson
Stephen P. Jackson University of Cambridge
Hugh Watkins
Hugh Watkins University of Oxford

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