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Biology and Biochemistry

D-Index
54
Citations
8421
World Ranking
15816
National Ranking
1111

Overview

Thomas Dobner is affiliated with the Heinrich-Pette-Institute in Germany and has contributed extensively to research in virology and molecular biology. Their work spans several overlapping fields including Biochemistry, Genetics and Molecular Biology, Medicine, and Immunology and Microbiology.

The main subfields of study associated with Dobner's research include Molecular Biology, Genetics, Immunology, Oncology, and Infectious Diseases.

Dobner has focused research efforts on various specialized topics, prominently including:

  • Virus-based gene therapy research
  • Interferon and immune responses
  • Viral Infectious Diseases and Gene Expression in Insects
  • CAR-T cell therapy research
  • Viral gastroenteritis research and epidemiology
  • Ubiquitin and proteasome pathways
  • RNA Research and Splicing

The scientist has authored multiple papers in leading publication venues, reflecting diverse interests in viral biology and immune mechanisms. Frequent publication venues include:

  • Viruses
  • Journal of Virology
  • mBio
  • PLoS Pathogens
  • Microbiology Spectrum

Selected recent research papers authored or co-authored by Dobner are:

  • Evidence That the Adenovirus Single-Stranded DNA Binding Protein Mediates the Assembly of Biomolecular Condensates to Form Viral Replication Compartments, 2021, Viruses
  • Viral DNA Binding Protein SUMOylation Promotes PML Nuclear Body Localization Next to Viral Replication Centers, 2020, mBio
  • Animal Models in Human Adenovirus Research, 2021, Biology
  • Fluorescent protein tagging of adenoviral proteins pV and pIX reveals 'late virion accumulation compartment', 2020, PLoS Pathogens
  • KIR3DS1 directs NK cell-mediated protection against human adenovirus infections, 2021, Science Immunology

Dobner has collaborated frequently with other researchers, with notable co-authors including:

  • Luca D. Bertzbach
  • Wing-Hang Ip
  • Paloma Hidalgo
  • Konstantin von Stromberg
  • Helga Hofmann-Sieber

Best Publications

  • Blockage by Adenovirus E4orf6 of Transcriptional Activation by the p53 Tumor Suppressor

    Thomas Dobner;Nobuo Horikoshi;Susanne Rubenwolf;Thomas Eugene Shenk

  • p300 Acts as a Transcriptional Coactivator for Mammalian Notch-1

    Franz Oswald;Birgitt Täuber;Thomas Dobner;Soizic Bourteele

  • Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A

    Ronit Shtrichman;Rakefet Sharf;Haim Barr;Thomas Dobner

  • Regulation of DNA-End Resection by hnRNPU-like Proteins Promotes DNA Double-Strand Break Signaling and Repair

    Sophie E. Polo;Andrew N. Blackford;J. Ross Chapman;Linda Baskcomb

  • The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

    Max Felle;Saskia Joppien;Attila Németh;Sarah Diermeier

  • DNA Virus Replication Compartments

    Melanie Schmid;Thomas Speiseder;Thomas Dobner;Ramon A. Gonzalez

  • The adenovirus E4orf6 protein can promote E1A/E1B-induced focus formation by interfering with p53 tumor suppressor function

    Michael Nevels;Susanne Rubenwolf;Thilo Spruss;Hans Wolf

  • "Hit-and-run" transformation by adenovirus oncogenes.

    Michael Nevels;Birgitt Täuber;Thilo Spruss;Hans Wolf

  • Proteasome-Dependent Degradation of Daxx by the Viral E1B-55K Protein in Human Adenovirus-Infected Cells

    Sabrina Schreiner;Peter Wimmer;Hüseyin Sirma;Roger D. Everett

  • Human Pathogens and the Host Cell SUMOylation System

    Peter Wimmer;Sabrina Schreiner;Thomas Dobner

  • SUMO-1 modification required for transformation by adenovirus type 5 early region 1B 55-kDa oncoprotein.

    Christian Endter;Julia Kzhyshkowska;Roland Stauber;Thomas Dobner

  • E1B 55-Kilodalton-Associated Protein: a Cellular Protein with RNA-Binding Activity Implicated in Nucleocytoplasmic Transport of Adenovirus and Cellular mRNAs

    Stefan Gabler;Holger Schütt;Peter Groitl;Hans Wolf

  • Molecular Evolution of Human Adenovirus (HAdV) Species C.

    Akshay Dhingra;Elias Hage;Tina Ganzenmueller;Sindy Böttcher

  • The adenovirus type 5 E1B-55K oncoprotein is a highly active shuttle protein and shuttling is independent of E4orf6, p53 and Mdm2.

    Friedrich Krätzer;Olaf Rosorius;Peter Heger;Nicole Hirschmann

  • Both BC-box motifs of adenovirus protein E4orf6 are required to efficiently assemble an E3 ligase complex that degrades p53.

    Paola Blanchette;Chi Ying Cheng;Qin Yan;Qin Yan;Gary Ketner

  • High-Affinity Rb Binding, p53 Inhibition, Subcellular Localization, and Transformation by Wild-Type or Tumor-Derived Shortened Merkel Cell Polyomavirus Large T Antigens

    Sophie Borchert;Manja Czech-Sioli;Friederike Neumann;Claudia Schmidt

  • Inhibition of TNF receptor 1 internalization by adenovirus 14.7K as a novel immune escape mechanism

    Wulf Schneider-Brachert;Vladimir Tchikov;Oliver Merkel;Marten Jakob

  • Structural analysis of the adenovirus type 5 E1B 55-kilodalton-E4orf6 protein complex.

    S Rubenwolf;H Schütt;M Nevels;H Wolf

  • Molecular regulation and biological function of adenovirus early genes: the E4 ORFs.

    Birgitt Täuber;Thomas Dobner

  • Identification of Integrin α3 as a New Substrate of the Adenovirus E4orf6/E1B 55-Kilodalton E3 Ubiquitin Ligase Complex

    Frédéric Dallaire;Paola Blanchette;Peter Groitl;Thomas Dobner

Frequent Co-Authors

Hans Wolf
Hans Wolf University of Amsterdam
Philip E. Branton
Philip E. Branton McGill University
Julia Kzhyshkowska
Julia Kzhyshkowska Heidelberg University
Elisabeth Kremmer
Elisabeth Kremmer Max Planck Society
Grant S. Stewart
Grant S. Stewart University of Birmingham
Albert Heim
Albert Heim Hannover Medical School
Adam Grundhoff
Adam Grundhoff Heinrich-Pette-Institute
Ronald T. Hay
Ronald T. Hay University of Dundee
Roger D. Everett
Roger D. Everett University of Glasgow
Joan Weliky Conaway
Joan Weliky Conaway The University of Texas Southwestern Medical Center

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