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Matthias Dobbelstein

Matthias Dobbelstein

D-Index & Metrics

Biology and Biochemistry

D-Index
56
Citations
10885
World Ranking
14464
National Ranking
1025

Overview

Matthias Dobbelstein is affiliated with the University of Göttingen in Germany and has an extensive publication record across multiple fields related to medicine and molecular biology. Their research contributions span key areas such as cancer-related molecular pathways, SARS-CoV-2 and COVID-19 research, biochemical and molecular research, DNA repair mechanisms, RNA research and splicing, epigenetics and DNA methylation, as well as bacteriophages and microbial interactions.

Dobbelstein has published significant work in various prestigious venues and has collaborated frequently with several coauthors. The scientist's most cited recent papers include:

  • Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies (2021), The EMBO Journal
  • Combined inhibition of Aurora-A and ATR kinases results in regression of MYCN-amplified neuroblastoma (2021), Nature Cancer
  • MYC multimers shield stalled replication forks from RNA polymerase (2022), Nature
  • The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis (2020), Journal of Clinical Investigation
  • MYCN recruits the nuclear exosome complex to RNA polymerase II to prevent transcription-replication conflicts (2021), Molecular Cell

Frequent coauthors in Dobbelstein's research include:

  • Antje Dickmanns
  • Kim M. Stegmann
  • Dirk Görlich
  • Anne Balkema-Buschmann
  • Uwe Groß

Dobbelstein's work has been published regularly in key scientific venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Antiviral Research
  • Cell Death and Disease
  • Cell Reports
  • iScience

Their main fields of study include medicine and biochemistry, genetics, and molecular biology. Within these fields, Dobbelstein has focused on various subfields including molecular biology, oncology, infectious diseases, epidemiology, and cell biology. This multidisciplinary approach underpins their research on several molecular and cellular mechanisms relevant to disease and therapy.

Best Publications

  • Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein

    Judith Roth;Matthias Dobbelstein;Deborah A. Freedman;Thomas Shenk

  • p53-Responsive MicroRNAs 192 and 215 Are Capable of Inducing Cell Cycle Arrest

    Christian J. Braun;Xin Zhang;Irina Savelyeva;Sonja Wolff

  • A polymorphic microsatellite that mediates induction of PIG3 by p53.

    Ana Contente;Alexandra Dittmer;Manuela C. Koch;Judith Roth

  • Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment

    E. M. Alexandrova;A. R. Yallowitz;D. Li;S. Xu

  • p21/CDKN1A Mediates Negative Regulation of Transcription by p53

    Kristina Löhr;Constanze Möritz;Ana Contente;Matthias Dobbelstein

  • Exploiting replicative stress to treat cancer

    Matthias Dobbelstein;Claus Storgaard Sørensen

  • Direct p53 Transcriptional Repression: In Vivo Analysis of CCAAT-Containing G2/M Promoters

    Carol Imbriano;Aymone Gurtner;Fabienne Cocchiarella;Silvia Di Agostino

  • Nuclear export of the E1B 55‐kDa and E4 34‐kDa adenoviral oncoproteins mediated by a rev‐like signal sequence

    Matthias Dobbelstein;Judith Roth;William Taylor Kimberly;William Taylor Kimberly;Arnold J. Levine

  • Targeting tumour-supportive cellular machineries in anticancer drug development

    Matthias Dobbelstein;Ute Moll

  • E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis

    M Lizé;S Pilarski;M Dobbelstein

  • Protection against apoptosis by the vaccinia virus SPI-2 (B13R) gene product.

    M Dobbelstein;T Shenk

  • The MDM2 oncoprotein binds specifically to RNA through its RING finger domain.

    Brian Elenbaas;Matthias Dobbelstein;Matthias Dobbelstein;Judith Roth;Thomas Eugene Shenk;Thomas Eugene Shenk

  • Inactivation of the p53-homologue p73 by the mdm2-oncoprotein

    Matthias Dobbelstein;Sandra Wienzek;Claudia König;Judith Roth

  • Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion.

    Ramona Schulz-Heddergott;Nadine Stark;Shelley J. Edmunds;Jinyu Li

  • Inactivation of p53 but not p73 by adenovirus type 5 E1B 55-kilodalton and E4 34-kilodalton oncoproteins

    Judith Roth;Claudia König;Sandra Wienzek;Silke Weigel

  • p53 induces the expression of its antagonist p73ΔN, establishing an autoregulatory feedback loop

    Natalia N Kartasheva;Ana Contente;Claudia Lenz-Stöppler;Judith Roth

  • MicroRNA-449 in cell fate determination

    Muriel Lizé;Alexander Klimke;Matthias Dobbelstein

  • YB-1 Relocates to the Nucleus in Adenovirus-infected Cells and Facilitates Viral Replication by Inducing E2 Gene Expression through the E2 Late Promoter

    Per S. Holm;Stephan Bergmann;Karsten Jürchott;Hermann Lage

  • p73 is an essential regulator of neural stem cell maintenance in embryonal and adult CNS neurogenesis.

    F Talos;A Abraham;A V Vaseva;L Holembowski

  • Endothelial p53 deletion improves angiogenesis and prevents cardiac fibrosis and heart failure induced by pressure overload in mice.

    Rajinikanth Gogiraju;Xingbo Xu;Magdalena L. Bochenek;Julia H. Steinbrecher

Frequent Co-Authors

Ute M. Moll
Ute M. Moll Stony Brook University
Thomas Shenk
Thomas Shenk Princeton University
Arnold J. Levine
Arnold J. Levine Institute for Advanced Study
Martin Eilers
Martin Eilers University of Würzburg
Guillermina Lozano
Guillermina Lozano The University of Texas MD Anderson Cancer Center
Michael P. Schön
Michael P. Schön University of Göttingen
Robert Huber
Robert Huber University of Duisburg-Essen
Bernd Wollnik
Bernd Wollnik University of Göttingen
Roberto Mantovani
Roberto Mantovani University of Milan

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