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Steven A. Johnsen

Steven A. Johnsen

D-Index & Metrics

Molecular Biology

D-Index
50
Citations
7462
World Ranking
2580
National Ranking
1266

Overview

Steven A. Johnsen is affiliated with the Mayo Clinic in the United States and has contributed extensively to research in biochemistry, genetics, molecular biology, and medicine. Their work spans various subfields including molecular biology, oncology, immunology, cancer research, and genetics.

Their publications often address topics related to epigenetics and DNA methylation, pancreatic and hepatic oncology research, ubiquitin and proteasome pathways, histone deacetylase inhibitors, immune cell function and interaction, cancer genomics and diagnostics, and protein degradation and inhibitors.

Frequent co-authors collaborating with Steven A. Johnsen include:

  • Feda H. Hamdan
  • Robyn Laura Kosinsky
  • Zeynab Najafova
  • Elisabeth Heßmann
  • Florian Wegwitz

Publication venues where Steven A. Johnsen has frequently contributed are:

  • Gastroenterology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Death and Disease
  • Cancer Research
  • Pancreatology

Among their recent scientific papers are:

  • Super enhancer regulation of cytokine-induced chemokine production in alcoholic hepatitis, 2021, Nature Communications
  • EZH2 Regulates Pancreatic Cancer Subtype Identity and Tumor Progression via Transcriptional Repression of GATA6, 2020, Cancer Research
  • Combined treatment with CBP and BET inhibitors reverses inadvertent activation of detrimental super enhancer programs in DIPG cells, 2020, Cell Death and Disease
  • Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma, 2020, International Journal of Cancer
  • Epigenomic Evaluation of Cholangiocyte Transforming Growth Factor-β Signaling Identifies a Selective Role for Histone 3 Lysine 9 Acetylation in Biliary Fibrosis, 2020, Gastroenterology

Steven A. Johnsen's work is largely centered on understanding molecular mechanisms underlying cancer progression, epigenetic regulation, and immune system interactions within disease contexts. The combination of molecular biology and oncology in their research addresses complex biological pathways including the role of super enhancers, histone modification, and various inhibitors targeting cancer cells.

Best Publications

  • The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene.

    David S. Waddell;Leslie M. Baehr;Jens van den Brandt;Steven A. Johnsen

  • Corrigendum: The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression.

    Efrat Shema;Itay Tirosh;Yael Aylon;Jing Huang

  • Estrogen receptor isoform‐specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERα or ERβ

    David G. Monroe;Barbara J. Getz;Steven A. Johnsen;B. Lawrence Riggs

  • Stem-Cell-like Properties and Epithelial Plasticity Arise as Stable Traits after Transient Twist1 Activation

    Johanna M. Schmidt;Elena Panzilius;Harald S. Bartsch;Martin Irmler

  • TGFβ inducible early gene enhances TGFβ/Smad-dependent transcriptional responses

    Steven A Johnsen;Malayannan Subramaniam;Ralf Janknecht;Thomas C Spelsberg

  • Bromodomain Protein BRD4 Is Required for Estrogen Receptor-Dependent Enhancer Activation and Gene Transcription

    Sankari Nagarajan;Tareq Hossan;Malik Alawi;Zeynab Najafova;Zeynab Najafova

  • HDAC inhibitor–dependent transcriptome and memory reinstatement in cognitive decline models

    Eva Benito;Hendrik Urbanke;Binu Ramachandran;Jonas Barth

  • CDK9 directs H2B monoubiquitination and controls replication‐dependent histone mRNA 3′‐end processing

    Judith Pirngruber;Andrei Shchebet;Lisa Schreiber;Efrat Shema

  • Estrogen-Dependent Gene Transcription in Human Breast Cancer Cells Relies upon Proteasome-Dependent Monoubiquitination of Histone H2B

    Tanja Prenzel;Yvonne Begus-Nahrmann;Frank Kramer;Magali Hennion

  • TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro.

    Malayannan Subramaniam;Genevieve Gorny;Steven A. Johnsen;David G. Monroe

  • The Histone H2B Monoubiquitination Regulatory Pathway Is Required for Differentiation of Multipotent Stem Cells

    Oleksandra Karpiuk;Zeynab Najafova;Zeynab Najafova;Frank Kramer;Magali Hennion

  • The ubiquitin ligase Rnf6 regulates local LIM kinase 1 levels in axonal growth cones

    Baris Tursun;Anne Schlüter;Marvin A. Peters;Birte Viehweger

  • Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling.

    Georg Emons;Melanie Spitzner;Sebastian Reineke;Janneke Möller

  • MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53

    Magdalena Wienken;Antje Dickmanns;Alice Nemajerova;Daniela Kramer

  • Modulation of Transforming Growth Factor β (TGFβ)/Smad Transcriptional Responses through Targeted Degradation of TGFβ-inducible Early Gene-1 by Human Seven in Absentia Homologue

    Steven A. Johnsen;Malayannan Subramaniam;David G. Monroe;Ralf Janknecht

  • Transcriptional regulation of Smad2 is required for enhancement of TGFβ/Smad signaling by TGFβ inducible early gene

    Steven A. Johnsen;Malayannan Subramaniam;Takenobu Katagiri;Ralf Janknecht

  • Role of TIEG1 in biological processes and disease states

    Malayannan Subramaniam;John R. Hawse;Steven A. Johnsen;Thomas C. Spelsberg

  • Overexpression of a Nuclear Protein, TIEG, Mimics Transforming Growth Factor-β Action in Human Osteoblast Cells

    Theresa E. Hefferan;Gregory G. Reinholz;David J. Rickard;Steven A. Johnsen

  • The enigmatic role of H2Bub1 in cancer.

    Steven A. Johnsen;Steven A. Johnsen

  • Loss of CHD1 causes DNA repair defects and enhances prostate cancer therapeutic responsiveness.

    Vijayalakshmi Kari;Wael Yassin Mansour;Wael Yassin Mansour;Sanjay Kumar Raul;Simon J Baumgart

Frequent Co-Authors

Stefan Knapp
Stefan Knapp Goethe University Frankfurt
Jens T. Siveke
Jens T. Siveke German Cancer Research Center
Matthias Dobbelstein
Matthias Dobbelstein University of Göttingen
Adam Grundhoff
Adam Grundhoff Heinrich-Pette-Institute
Klaus Pantel
Klaus Pantel Universität Hamburg
Ronald Simon
Ronald Simon Universität Hamburg
Malik Alawi
Malik Alawi University Medical Center Hamburg-Eppendorf
Stefan M. Pfister
Stefan M. Pfister German Cancer Research Center
Andre Fischer
Andre Fischer University of Göttingen

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