World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
69
Citations
29964
World Ranking
7236
National Ranking
3319

Research.com Recognitions

  • 2019 - Paul Marks Prize for Cancer Research, Memorial Sloan Kettering Cancer Center

Overview

Christopher R. Vakoc is affiliated with the Cold Spring Harbor Laboratory in the United States. Their research spans multiple fields with a primary focus on Biochemistry, Genetics and Molecular Biology, and Medicine.

The scientist's work predominantly explores Molecular Biology, Oncology, Cancer Research, Immunology, and Hematology. Key topics addressed in their research include:

  • Protein Degradation and Inhibitors
  • Epigenetics and DNA Methylation
  • Chromatin Remodeling and Cancer
  • Histone Deacetylase Inhibitors Research
  • Pancreatic and Hepatic Oncology Research
  • Acute Myeloid Leukemia Research
  • Genomics and Chromatin Dynamics

Christopher R. Vakoc's recent published works consist of the following papers:

  • New Approaches to SCLC Therapy: From the Laboratory to the Clinic, 2020, Journal of Thoracic Oncology
  • Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment, 2024, Cancer Cell
  • Intraductal Transplantation Models of Human Pancreatic Ductal Adenocarcinoma Reveal Progressive Transition of Molecular Subtypes, 2020, Cancer Discovery
  • SOAT1 promotes mevalonate pathway dependency in pancreatic cancer, 2020, The Journal of Experimental Medicine
  • Squamous trans-differentiation of pancreatic cancer cells promotes stromal inflammation, 2020, eLife

Frequent coauthors collaborating with Christopher R. Vakoc include:

  • Olaf Klingbeil
  • Xiaoli Wu
  • Kenneth Chang
  • Osama E. Demerdash
  • David A. Tuveson

The scientist's work often appears in reputable academic venues, with multiple publications in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Cancer Discovery
  • Nature Communications
  • Cancer Cell

Christopher R. Vakoc has been recognized with the Paul Marks Prize for Cancer Research from Memorial Sloan Kettering Cancer Center in 2019.

Best Publications

  • BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

    Jake E. Delmore;Ghayas C. Issa;Madeleine E. Lemieux;Peter B. Rahl

  • Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

    Jakob Lovén;Heather A. Hoke;Charles Y. Lin;Charles Y. Lin;Ashley Lau

  • RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

    Johannes Zuber;Junwei Shi;Junwei Shi;Eric Wang;Amy R. Rappaport;Amy R. Rappaport

  • Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data.

    Charles M. Rudin;John T. Poirier;Lauren Averett Byers;Caroline Dive

  • Promoter-bound METTL3 maintains myeloid leukaemia by m 6 A-dependent translation control

    Isaia Barbieri;Konstantinos Tzelepis;Luca Pandolfini;Junwei Shi

  • The Mechanisms behind the Therapeutic Activity of BET Bromodomain Inhibition

    Junwei Shi;Christopher R. Vakoc

  • Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

    Hervé Tiriac;Pascal Belleau;Dannielle D Engle;Dennis Plenker

  • Histone H3 Lysine 9 Methylation and HP1γ Are Associated with Transcription Elongation through Mammalian Chromatin

    Christopher R. Vakoc;Sean A. Mandat;Benjamin A. Olenchock;Gerd A. Blobel;Gerd A. Blobel

  • Discovery of cancer drug targets by CRISPR-Cas9 screening of protein domains

    Junwei Shi;Eric Wang;Joseph P. Milazzo;Zhihua Wang

  • Proximity among Distant Regulatory Elements at the β-Globin Locus Requires GATA-1 and FOG-1

    Christopher R. Vakoc;Danielle L. Letting;Danielle L. Letting;Nele Gheldof;Tomoyuki Sawado

  • DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells.

    David J. Steger;Martina I. Lefterova;Lei Ying;Aaron J. Stonestrom

  • Transcriptional plasticity promotes primary and acquired resistance to BET inhibition

    Philipp Rathert;Mareike Roth;Tobias Neumann;Felix Muerdter

  • Global regulation of erythroid gene expression by transcription factor GATA-1

    John J. Welch;Jason A. Watts;Christopher R. Vakoc;Yu Yao

  • Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

    Junwei Shi;Warren A. Whyte;Cinthya J. Zepeda-Mendoza;Cinthya J. Zepeda-Mendoza;Joseph P. Milazzo

  • Profile of histone lysine methylation across transcribed mammalian chromatin

    Christopher R. Vakoc;Mira M. Sachdeva;Hongxin Wang;Gerd A. Blobel;Gerd A. Blobel

  • Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis

    Jae Seok Roe;Chang Il Hwang;Chang Il Hwang;Tim D.D. Somerville;Joseph P. Milazzo

  • BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance

    Nilgun Tasdemir;Ana Banito;Jae Seok Roe;Direna Alonso-Curbelo

  • BET Bromodomain Inhibition Suppresses the Function of Hematopoietic Transcription Factors in Acute Myeloid Leukemia.

    Jae Seok Roe;Fatih Mercan;Keith Rivera;Darryl J. Pappin

  • POU2F3 is a master regulator of a tuft cell-like variant of small cell lung cancer.

    Yu-Han Huang;Olaf Klingbeil;Xue-Yan He;Xiaoli S. Wu;Xiaoli S. Wu

  • The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability.

    Bryan King;Thomas Trimarchi;Linsey Reavie;Linsey Reavie;Luyao Xu

Frequent Co-Authors

Gerd A. Blobel
Gerd A. Blobel Children's Hospital of Philadelphia
Scott W. Lowe
Scott W. Lowe Memorial Sloan Kettering Cancer Center
Johannes Zuber
Johannes Zuber Research Institute of Molecular Pathology
David A. Tuveson
David A. Tuveson Cold Spring Harbor Laboratory
James E. Bradner
James E. Bradner Amgen (United States)
Mitchell J. Weiss
Mitchell J. Weiss St. Jude Children's Research Hospital
Peter Valent
Peter Valent Medical University of Vienna
W. Richard McCombie
W. Richard McCombie Cold Spring Harbor Laboratory
Ross C. Hardison
Ross C. Hardison Pennsylvania State University

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