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Biology and Biochemistry

D-Index
55
Citations
19210
World Ranking
14771
National Ranking
405

Overview

Mark A. Dawson is affiliated with the Peter MacCallum Cancer Centre in Australia. Their research spans multiple domains within biochemistry, genetics, and molecular biology, with a significant focus on medicine. The bulk of their work centers on molecular biology, immunology, hematology, cancer research, and genetics.

Their primary research topics include protein degradation and inhibitors, epigenetics and DNA methylation, genomics and chromatin dynamics, cancer genomics and diagnostics, CRISPR and genetic engineering, cancer-related gene regulation, and single-cell and spatial transcriptomics.

Frequent publication venues for their research include:

  • Blood
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Experimental Hematology
  • Nature Communications
  • Cancer Discovery

Recent papers authored or co-authored by Mark A. Dawson feature in high-impact journals and cover diverse topics in cancer biology and immunology:

  • Targeting the epigenetic regulation of antitumour immunity, 2020, Nature Reviews Drug Discovery
  • Non-genetic mechanisms of therapeutic resistance in cancer, 2020, Nature Reviews Cancer
  • Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation, 2020, Science
  • A druggable copper-signalling pathway that drives inflammation, 2023, Nature
  • Non-genetic determinants of malignant clonal fitness at single-cell resolution, 2021, Nature

Mark A. Dawson frequently collaborates with several researchers, including:

  • Enid Y.N. Lam
  • Dane Vassiliadis
  • Sarah-Jane Dawson
  • Yih-Chih Chan
  • Katie Fennell

Best Publications

  • Cancer epigenetics: from mechanism to therapy.

    Mark A. Dawson;Tony Kouzarides

  • Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

    Mark A. Dawson;Rab K. Prinjha;Antje Dittmann;George Giotopoulos

  • CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity

    Marian L Burr;Marian L Burr;Marian L Burr;Christina E Sparbier;Yih-Chih Chan;James C Williamson

  • JAK2 phosphorylates histone H3Y41 and excludes HP1α from chromatin

    Mark A. Dawson;Andrew J. Bannister;Berthold Göttgens;Samuel D. Foster

  • BET inhibitor resistance emerges from leukaemia stem cells

    Chun Yew Fong;Omer Gilan;Omer Gilan;Enid Y N Lam;Alan Rubin

  • TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS

    Rachel Deplus;Benjamin Delatte;Marie K Schwinn;Matthieu Defrance

  • An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

    Marian L. Burr;Marian L. Burr;Marian L. Burr;Christina E. Sparbier;Christina E. Sparbier;Kah Lok Chan;Kah Lok Chan;Yih-Chih Chan

  • Targeting Epigenetic Readers in Cancer

    Mark A Dawson;Tony Kouzarides;Brian J P Huntly

  • The roles of DNA, RNA and histone methylation in ageing and cancer.

    Ewa M Michalak;Ewa M Michalak;Marian L Burr;Marian L Burr;Marian L Burr;Andrew J Bannister;Mark A Dawson;Mark A Dawson

  • Non-genetic mechanisms of therapeutic resistance in cancer.

    Jean-Christophe Marine;Sarah-Jane Dawson;Sarah-Jane Dawson;Mark A Dawson;Mark A Dawson

  • Targeting the epigenetic regulation of antitumour immunity.

    Simon J Hogg;Simon J Hogg;Simon J Hogg;Paul A Beavis;Paul A Beavis;Mark A Dawson;Mark A Dawson;Ricky W Johnstone;Ricky W Johnstone

  • Ibrutinib plus Venetoclax for the Treatment of Mantle-Cell Lymphoma

    Constantine S Tam;Mary Ann Anderson;Christiane Pott;Rishu Agarwal

  • The cancer epigenome: Concepts, challenges, and therapeutic opportunities

    Mark A. Dawson

  • Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation

    Omer Gilan;Omer Gilan;Inmaculada Rioja;Kathy Knezevic;Matthew J. Bell

  • Two routes to leukemic transformation after a JAK2 mutation–positive myeloproliferative neoplasm

    Philip A. Beer;François Delhommeau;Jean-Pierre LeCouédic;Mark A. Dawson

  • Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells

    Iva A. Tchasovnikarova;Richard T. Timms;Nicholas J. Matheson;Kim Wals

  • Multiplexed Proteome Dynamics Profiling Reveals Mechanisms Controlling Protein Homeostasis

    Mikhail M. Savitski;Nico Zinn;Maria Faelth-Savitski;Daniel Poeckel

  • Recurrent mutations, including NPM1c, activate a BRD4-dependent core transcriptional program in acute myeloid leukemia.

    M A Dawson;E J Gudgin;S J Horton;G Giotopoulos

  • Dynamic molecular monitoring reveals that SWI-SNF mutations mediate resistance to ibrutinib plus venetoclax in mantle cell lymphoma.

    Rishu Agarwal;Rishu Agarwal;Yih Chih Chan;Yih Chih Chan;Constantine S. Tam;Constantine S. Tam;Tane Hunter;Tane Hunter

  • LIF-independent JAK signalling to chromatin in embryonic stem cells uncovered from an adult stem cell disease

    Dean S Griffiths;Juan Li;Mark A Dawson;Mark A Dawson;Matthew W B Trotter

Frequent Co-Authors

Ricky W. Johnstone
Ricky W. Johnstone Peter MacCallum Cancer Centre
Rab K. Prinjha
Rab K. Prinjha GlaxoSmithKline (United Kingdom)
Tony Kouzarides
Tony Kouzarides University of Cambridge
Anthony T. Papenfuss
Anthony T. Papenfuss Walter and Eliza Hall Institute of Medical Research
Rodney J. Hicks
Rodney J. Hicks Peter MacCallum Cancer Centre
John F. Seymour
John F. Seymour Peter MacCallum Cancer Centre
Andrew J. Bannister
Andrew J. Bannister University of Cambridge
Constantine S. Tam
Constantine S. Tam University of Melbourne
Berthold Göttgens
Berthold Göttgens University of Cambridge
Anthony R. Green
Anthony R. Green University of Cambridge

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