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Chemistry

D-Index
45
Citations
8733
World Ranking
16323
National Ranking
904

Overview

Chun-wa Chung is affiliated with GlaxoSmithKline in the United Kingdom and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, with specific emphasis on molecular biology and hematology. Their publication record indicates engagement with both foundational and applied research areas within medicine, notably oncology and organic chemistry.

The primary topics of Chun-wa Chung's research include:

  • Protein Degradation and Inhibitors
  • Multiple Myeloma Research and Treatments
  • Ubiquitin and Proteasome Pathways
  • Peptidase Inhibition and Analysis
  • Mass Spectrometry Techniques and Applications
  • Click Chemistry and Applications
  • Analytical Chemistry and Chromatography

Chun-wa Chung has coauthored numerous scientific articles alongside frequent collaborators such as Rab K. Prinjha, Paul Bamborough, Inmaculada Rioja, Emmanuel H. Demont, and Laurie Gordon. These collaborations highlight a focused research community within their specialty.

The scientist has published papers in several prominent journals, with a significant number featured in the Journal of Medicinal Chemistry, followed by contributions to ACS Medicinal Chemistry Letters, bioRxiv, Communications Biology, and Angewandte Chemie International Edition. Frequent publication venues include:

  • Journal of Medicinal Chemistry
  • ACS Medicinal Chemistry Letters
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Communications Biology
  • Angewandte Chemie International Edition

Recent publications by Chun-wa Chung include:

  • "Selective targeting of BD1 and BD2 of the BET proteins in cancer and immunoinflammation" (2020, Science)
  • "Author Correction: Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis" (2022, Communications Biology)
  • "Discovery and Characterisation of Highly Cooperative FAK-Degrading PROTACs" (2021, Angewandte Chemie International Edition)
  • "Structural Insights into PROTAC-Mediated Degradation of Bcl-xL" (2020, ACS Chemical Biology)
  • "GSK789: A Selective Inhibitor of the First Bromodomains (BD1) of the Bromo and Extra Terminal Domain (BET) Proteins" (2020, Journal of Medicinal Chemistry)

The work of Chun-wa Chung predominantly explores mechanisms of protein degradation and inhibition, with particular attention to PROTACs (proteolysis-targeting chimeras) and bromodomain inhibitors, which are crucial in cancer and immunoinflammation studies. These areas reflect ongoing interest in therapeutic strategies targeting cellular regulatory pathways through chemical biology and medicinal chemistry approaches.

Best Publications

  • A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

    Laurens Kruidenier;Chun-wa Chung;Zhongjun Cheng;John Liddle

  • Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

    Huw D Lewis;John Liddle;Jim E Coote;Stephen J Atkinson

  • Biophysics in drug discovery: impact, challenges and opportunities

    Jean-Paul Renaud;Chun-wa Chung;U. Helena Danielson;Ursula Egner

  • Discovery and Characterization of Small Molecule Inhibitors of the Bet Family Bromodomains.

    Chun-wa Chung;Hervé Coste;Julia H. White;Olivier Mirguet

  • Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains

    Olivier Mirguet;Romain Gosmini;Jérôme Toum;Catherine A. Clément

  • Identification of a Novel Series of Bet Family Bromodomain Inhibitors: Binding Mode and Profile of I-Bet151 (Gsk1210151A).

    Jonathan Seal;Yann Lamotte;Frédéric Donche;Anne Bouillot

  • Fragment-Based Discovery of Bromodomain Inhibitors Part 1: Inhibitor Binding Modes and Implications for Lead Discovery.

    Chun-wa Chung;Anthony W. Dean;James M. Woolven;Paul Bamborough

  • Fragment-based discovery of bromodomain inhibitors part 2: optimization of phenylisoxazole sulfonamides.

    Paul Bamborough;Hawa Diallo;Jonathan D. Goodacre;Laurie Gordon

  • The Discovery of I-BET726 (GSK1324726A), a Potent Tetrahydroquinoline ApoA1 Up-Regulator and Selective BET Bromodomain Inhibitor

    Romain Gosmini;Van Loc Nguyen;Jérôme Toum;Christophe Simon

  • Identification of a glycosaminoglycan binding surface on human interleukin-8.

    Gabriele S. V. Kuschert;Arlene J. Hoogewerf;Amanda E. I. Proudfoot;Chun-wa Chung

  • Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition

    Natalie H. Theodoulou;Paul Bamborough;Andrew J. Bannister;Isabelle Becher

  • Author Correction: Cycloalkane-modified amphiphilic polymers provide direct extraction of membrane proteins for CryoEM analysis

    Unknown

  • Discovery and Characterization of GSK2801, a Selective Chemical Probe for the Bromodomains BAZ2A and BAZ2B.

    Peiling Chen;Apirat Chaikuad;Paul Bamborough;Marcus Bantscheff

  • Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP.

    Henrik Johansson;Henrik Johansson;Yi-Chun Isabella Tsai;Ken Fantom;Chun-Wa Chung

  • The Commonly Used PI3-Kinase Probe LY294002 Is an Inhibitor of BET Bromodomains

    Antje Dittmann;Thilo Werner;Chun-Wa Chung;Mikhail M. Savitski

  • 1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain

    Emmanuel H. Demont;Paul Bamborough;Chun-wa Chung;Peter D. Craggs

  • Discovery of Tetrahydroquinoxalines as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with Selectivity for the Second Bromodomain

    Robert P. Law;Stephen J. Atkinson;Paul Bamborough;Chun-wa Chung

  • Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe

    Philip G. Humphreys;Paul Bamborough;Chun-wa Chung;Peter D. Craggs

  • Enabling Lead Discovery for Histone Lysine Demethylases by High-Throughput RapidFire Mass Spectrometry

    Sue E. Hutchinson;Melanie V. Leveridge;Michelle L. Heathcote;Peter Francis

  • Discovery and Characterisation of Highly Cooperative FAK-Degrading PROTACs.

    Robert P Law;Joao Nunes;Chun-Wa Chung;Marcus Bantscheff

  • Selectivity of Kinase Inhibitor Fragments

    Paul Bamborough;Murray J. Brown;John A. Christopher;Chun-wa Chung

  • Structure-Based Optimization of Naphthyridones into Potent ATAD2 Bromodomain Inhibitors.

    Paul Bamborough;Chun-wa Chung;Rebecca C. Furze;Paola Grandi

  • Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors

    Emmanuel H. Demont;Chun-wa Chung;Rebecca C. Furze;Paola Grandi

Frequent Co-Authors

Rab K. Prinjha
Rab K. Prinjha GlaxoSmithKline (United Kingdom)
Gerard Drewes
Gerard Drewes GlaxoSmithKline (United Kingdom)
Marcus Bantscheff
Marcus Bantscheff GlaxoSmithKline (United Kingdom)
Tony Kouzarides
Tony Kouzarides University of Cambridge
Mark A. Dawson
Mark A. Dawson Peter MacCallum Cancer Centre
Udo Oppermann
Udo Oppermann University of Oxford
Mikhail M. Savitski
Mikhail M. Savitski European Bioinformatics Institute
Christopher J. Schofield
Christopher J. Schofield University of Oxford
James H. Naismith
James H. Naismith Rosalind Franklin Institute
David F. Tough
David F. Tough GlaxoSmithKline (United Kingdom)

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