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Chemistry

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81
Citations
21742
World Ranking
3279
National Ranking
185

Biology and Biochemistry

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84
Citations
26073
World Ranking
3307
National Ranking
247

Overview

Udo Oppermann is affiliated with the University of Oxford in the United Kingdom. Their research spans several fields, primarily in Biochemistry, Genetics and Molecular Biology, and Medicine, with a focused involvement in subfields such as Molecular Biology, Oncology, Hematology, Cancer Research, and Immunology.

Their scientific contributions cover a range of topics including:

  • Multiple Myeloma Research and Treatments
  • Epigenetics and DNA Methylation
  • Protein Degradation and Inhibitors
  • Histone Deacetylase Inhibitors Research
  • Cancer Genomics and Diagnostics
  • Peptidase Inhibition and Analysis
  • Single-cell and spatial transcriptomics

Among the recent papers authored or coauthored by Udo Oppermann are:

  • "Nanopore sequencing of single-cell transcriptomes with scCOLOR-seq," 2021, Nature Biotechnology
  • "Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism," 2020, Proceedings of the National Academy of Sciences
  • "Mass cytometry analysis reveals a distinct immune environment in peritoneal fluid in endometriosis: a characterisation study," 2020, BMC Medicine
  • "Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy," 2021, Nature Communications
  • "Inhibition of Histone H3K27 Demethylases Inactivates Brachyury (TBXT) and Promotes Chordoma Cell Death," 2020, Cancer Research

Frequent coauthors with whom Oppermann collaborates include Adam P. Cribbs, Martin Philpott, Anjan Thakurta, Sarah Gooding, and Karthik Ramasamy.

Their work is published regularly in a number of scientific journals, with frequent appearances in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood
  • Clinical Lymphoma Myeloma & Leukemia
  • Nature Communications
  • Scientific Reports

Best Publications

  • Medium- and short-chain dehydrogenase/reductase gene and protein families: The SDR superfamily: functional and structural diversity within a family of metabolic and regulatory enzymes

    K L Kavanagh;H Jornvall;Bengt Persson;U Oppermann

  • Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility

    D M Evans;Spencer Cca.;J J Pointon;Z Su

  • A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

    Laurens Kruidenier;Chun-wa Chung;Zhongjun Cheng;John Liddle

  • Protein production and purification.

    S Gräslund

  • Short-chain dehydrogenases/reductases (SDR): the 2002 update.

    Udo Oppermann;Charlotta Filling;Malin Hult;Naeem Shafqat

  • Critical Residues for Structure and Catalysis in Short-chain Dehydrogenases/Reductases

    Charlotta Filling;Kurt D. Berndt;Kurt D. Berndt;Jordi Benach;Stefan Knapp

  • The relationship between the chemistry and biological activity of the bisphosphonates.

    F H Ebetino;A M Hogan;S Sun;M K Tsoumpra

  • Short‐chain dehydrogenases/reductases (SDRs)

    Yvonne Kallberg;Udo Oppermann;Hans Jörnvall;Bengt Persson

  • The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.

    K. L. Kavanagh;K. Guo;James Edward Dunford;James Edward Dunford;James Edward Dunford;X. Wu

  • Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy.

    R. G. G. Russell;Z. Xia;J. E. Dunford;U. Oppermann

  • The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative

    Bengt Persson;Yvonne Kallberg;Yvonne Kallberg;James E. Bray;Elspeth Bruford

  • Codon optimization can improve expression of human genes in Escherichia coli: A multi-gene study

    Nicola A. Burgess-Brown;Sujata Sharma;Frank Sobott;Christoph Loenarz

  • Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity.

    Stanley S. Ng;Kathryn L. Kavanagh;Michael A. McDonough;Danica Butler

  • Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.

    G Kochan;T Krojer;D Harvey;R Fischer

  • Short-chain dehydrogenase/reductase (SDR) relationships: a large family with eight clusters common to human, animal, and plant genomes.

    Yvonne Kallberg;Udo Oppermann;Hans Jörnvall;Bengt Persson

  • Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology.

    Udo Oppermann

  • Dynamic protein methylation in chromatin biology

    S S Ng;W W Yue;U Oppermann;R J Klose

  • Structure and function of human 17beta-hydroxysteroid dehydrogenases.

    Petra Lukacik;Kathryn L. Kavanagh;Udo Oppermann

  • Inhibitor Scaffolds for 2-Oxoglutarate-Dependent Histone Lysine Demethylases.

    Nathan R Rose;Stanley S Ng;Jasmin Mecinović;Benoît M R Liénard

  • Coenzyme-based functional assignments of short-chain dehydrogenases/reductases (SDRs)

    Bengt Persson;Yvonne Kallberg;Udo Oppermann;Hans Jörnvall

Frequent Co-Authors

Cheryl H. Arrowsmith
Cheryl H. Arrowsmith Structural Genomics Consortium
Aled M. Edwards
Aled M. Edwards Structural Genomics Consortium
Paul Brennan
Paul Brennan International Agency For Research On Cancer
Christopher J. Schofield
Christopher J. Schofield University of Oxford
Opher Gileadi
Opher Gileadi Karolinska Institute
Michael A. McDonough
Michael A. McDonough University of Oxford
Panagis Filippakopoulos
Panagis Filippakopoulos Structural Genomics Consortium
Hans Jörnvall
Hans Jörnvall Karolinska Institute
Adrian Edwards
Adrian Edwards Cardiff University
Stefan Knapp
Stefan Knapp Goethe University Frankfurt

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