Michael A. McDonough

What is he best known for?

The fields of study he is best known for:

• Enzyme
• Gene
• Amino acid

His primary areas of study are Biochemistry, Transcription factor, Hydroxylation, Hypoxia-inducible factors and Enzyme. His study in Binding site, Oxygenase, Demethylase, Active site and Histone are all subfields of Biochemistry. His biological study spans a wide range of topics, including Nucleic acid, Stereochemistry and Small molecule.

His Transcription factor research incorporates elements of Oxidoreductase and Protein structure. The various areas that Michael A. McDonough examines in his Hydroxylation study include Hypoxia-Inducible Factor-Proline Dioxygenases, Hypoxia-Inducible Factor 1 and Ankyrin repeat. His Enzyme research is multidisciplinary, incorporating perspectives in Structure–activity relationship and Cephalosporin.

His most cited work include:

• The Obesity-Associated FTO Gene Encodes a 2-Oxoglutarate–Dependent Nucleic Acid Demethylase (1095 citations)
• The oncometabolite 2‐hydroxyglutarate inhibits histone lysine demethylases (655 citations)
• Structural studies on 2-oxoglutarate oxygenases and related double-stranded β-helix fold proteins (329 citations)

What are the main themes of his work throughout his whole career to date?

His main research concerns Biochemistry, Stereochemistry, Oxygenase, Hydroxylation and Enzyme. His study in Biochemistry focuses on Binding site, Hypoxia-inducible factors, Transcription factor, Demethylase and Protein structure. His Stereochemistry research includes elements of Ligand, Hydrolase, Crystal structure, Active site and Carnitine biosynthesis.

His study looks at the relationship between Oxygenase and fields such as Small molecule, as well as how they intersect with chemical problems. His Hydroxylation research is multidisciplinary, relying on both Ribosomal protein, Asparagine, Substrate, Dioxygenase and Ankyrin repeat. His Enzyme study combines topics in areas such as Crystallography and Structure–activity relationship.

He most often published in these fields:

• Biochemistry (55.63%)
• Stereochemistry (40.40%)
• Oxygenase (27.81%)

What were the highlights of his more recent work (between 2016-2021)?

• Stereochemistry (40.40%)
• Biochemistry (55.63%)
• Oxygenase (27.81%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Stereochemistry, Biochemistry, Oxygenase, Active site and Enzyme. Michael A. McDonough combines subjects such as β lactamases, Ligand, Meropenem, Catalysis and Substrate with his study of Stereochemistry. Michael A. McDonough integrates Biochemistry and Toxoplasma gondii in his research.

He has researched Oxygenase in several fields, including Oxidoreductase, ASPH, Asparagine and Hydroxylation. His research integrates issues of Cofactor, Gene, Protein structure, Computational biology and Drug discovery in his study of Active site. His Enzyme research incorporates themes from Cell cycle and Gene expression.

Between 2016 and 2021, his most popular works were:

• Cyclic Boronates Inhibit All Classes of β-Lactamases (60 citations)
• NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors (35 citations)
• Structural and stereoelectronic insights into oxygenase-catalyzed formation of ethylene from 2-oxoglutarate (26 citations)

In his most recent research, the most cited papers focused on:

• Enzyme
• Gene
• Amino acid

Stereochemistry, Hydrolase, Enzyme, Active site and Meropenem are his primary areas of study. His Stereochemistry research is multidisciplinary, incorporating elements of Oxidoreductase, Oxygenase and β lactamases. The Hydrolase study which covers Serine that intersects with Antibiotic resistance, Bicyclic molecule and Transition state analog.

Biochemistry covers he research in Enzyme. His study in Active site is interdisciplinary in nature, drawing from both Protein structure, Combinatorial chemistry and Metal chelation. His Meropenem research includes themes of Crystallography, In vitro, Thiol and Isoquinoline.