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Clara Franzini-Armstrong

Clara Franzini-Armstrong

D-Index & Metrics

Biology and Biochemistry

D-Index
85
Citations
21597
World Ranking
3203
National Ranking
1621

Research.com Recognitions

  • 2001 - Fellow of the Royal Society, United Kingdom
  • 1995 - Member of the National Academy of Sciences

Overview

Clara Franzini-Armstrong is affiliated with the University of Pennsylvania in the United States. Their research spans multiple areas within biochemistry, genetics, and molecular biology, focusing mainly on cellular and molecular neuroscience, molecular biology, and cardiology and cardiovascular medicine.

The primary fields of study addressed in their work include:

  • Biochemistry, Genetics and Molecular Biology

Within these areas, their subfields of study cover:

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cardiology and Cardiovascular Medicine
  • Clinical Biochemistry
  • Cell Biology

The main topics in their research portfolio reflect an interest in mitochondrial function and pathology, ion channel regulation and function, and neuroscience and neuropharmacology research. Other topics include metabolism and genetic disorders, neurobiology and insect physiology research, nicotinic acetylcholine receptors study, and cellular transport and secretion.

  • Mitochondrial Function and Pathology
  • Ion channel regulation and function
  • Neuroscience and Neuropharmacology Research
  • Metabolism and Genetic Disorders
  • Neurobiology and Insect Physiology Research
  • Nicotinic Acetylcholine Receptors Study
  • Cellular transport and secretion

Several recent publications illustrate the scope of their work:

  • Effects of Germline VHL Deficiency on Growth, Metabolism, and Mitochondria, 2020, New England Journal of Medicine
  • The structural basis for intermitochondrial communications is fundamentally different in cardiac and skeletal muscle, 2020, Experimental Physiology
  • The distal C terminus of the dihydropyridine receptor β1asubunit is essential for tetrad formation in skeletal muscle, 2022, Proceedings of the National Academy of Sciences
  • Ultrastructure of primary pacemaking cells in rabbit sino-atrial node cells indicates limited sarcoplasmic reticulum content, 2020, FASEB BioAdvances
  • The location of InsP3 receptors in Purkinje cells of murine cerebellum does not supports a direct interaction in the transfer of calcium ions between ER and mitochondria, 2021, European Journal of Translational Myology

Frequent coauthors in their publications include:

  • V. Ramesh Iyer
  • Federico Formenti
  • Manuela Lavorato
  • Gerhard Meissner
  • Silverio Perrotta

Their work has been published notably in the following venues:

  • UNC Libraries
  • European Journal of Translational Myology
  • New England Journal of Medicine
  • Experimental Physiology
  • Proceedings of the National Academy of Sciences

Regarding recognitions, Clara Franzini-Armstrong was elected Fellow of the Royal Society, United Kingdom in 2001 and became a Member of the National Academy of Sciences in 1995.

Best Publications

  • Ryanodine receptors of striated muscles: a complex channel capable of multiple interactions

    C. Franzini-Armstrong;F. Protasi

  • Structural evidence for direct interaction between the molecular components of the transverse tubule/sarcoplasmic reticulum junction in skeletal muscle.

    B A Block;T Imagawa;K P Campbell;C Franzini-Armstrong

  • Shape, Size, and Distribution of Ca2+ Release Units and Couplons in Skeletal and Cardiac Muscles

    Clara Franzini-Armstrong;Feliciano Protasi;Venkat Ramesh

  • Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia

    Björn C. Knollmann;Nagesh Chopra;Thinn Hlaing;Brandy Akin

  • STUDIES OF THE TRIAD I. Structure of the Junction in Frog Twitch Fibers

    Clara Franzini-Armstrong

  • Structure and Development of E-C Coupling Units in Skeletal Muscle

    C Franzini-Armstrong;A O Jorgensen

  • The brain ryanodine receptor: a caffeine-sensitive calcium release channel

    Peter S. McPhersonx;Young Kee Kim;Hector Valdivia;C. Michael Knudson

  • Regulation of Ca2+ signaling in transgenic mouse cardiac myocytes overexpressing calsequestrin.

    L. R. Jones;Y. J. Suzuki;Wei Wang;Y. M. Kobayashi

  • Molecular architecture of membranes involved in excitation-contraction coupling of cardiac muscle.

    Xin-Hui Sun;F. Protasi;M. Takahashi;H. Takeshima

  • LOCALIZATION OF CALCIUM-ACCUMULATING STRUCTURES IN STRIATED MUSCLE FIBERS.

    LeRoy L. Costantin;Clara Franzini-Armstrong;Richard J. Podolsky

  • Subunit identification and reconstitution of the N-type Ca2+ channel complex purified from brain

    D R Witcher;M De Waard;J Sakamoto;C Franzini-Armstrong

  • Formation of junctions involved in excitation-contraction coupling in skeletal and cardiac muscle.

    Bernhard E. Flucher;Clara Franzini-Armstrong

  • The structure of calsequestrin in triads of vertebrate skeletal muscle: a deep-etch study.

    C Franzini-Armstrong;L J Kenney;E Varriano-Marston

  • Junctional feet and particles in the triads of a fast-twitch muscle fibre.

    Clara Franzini-Armstrong;Grazia Nunzi

  • The relative contributions of the folds and caveolae to the surface membrane of frog skeletal muscle fibres at different sarcomere lengths.

    A F Dulhunty;C Franzini-Armstrong

  • Stac3 is a component of the excitation-contraction coupling machinery and mutated in Native American myopathy

    Eric J. Horstick;Jeremy W. Linsley;James J. Dowling;Michael A. Hauser

  • Further characterization of light and heavy sarcoplasmic reticulum vesicles. Identification of the 'sarcoplasmic reticulum feet' associated with heavy sarcoplasmic reticulum vesicles

    Kevin P. Campbell;Clara Franzini-Armstrong;Adil E. Shamoo

  • Ca2+ blinks: rapid nanoscopic store calcium signaling.

    Didier X. P. Brochet;Dongmei Yang;Alessandro Di Maio;W. Jonathan Lederer

  • Transport of Ca2+ from Sarcoplasmic Reticulum to Mitochondria in Rat Ventricular Myocytes

    V K Sharma;V Ramesh;C Franzini-Armstrong;S S Sheu

  • Simultaneous maturation of transverse tubules and sarcoplasmic reticulum during muscle differentiation in the mouse.

    Clara Franzini-Armstrong

Frequent Co-Authors

Paul D. Allen
Paul D. Allen St James's University Hospital
Feliciano Protasi
Feliciano Protasi University of Chieti-Pescara
Yale E. Goldman
Yale E. Goldman University of Pennsylvania
Larry R. Jones
Larry R. Jones Indiana University
Kurt G. Beam
Kurt G. Beam University of Colorado Denver
Isaac N. Pessah
Isaac N. Pessah University of California, Davis
Kevin P. Campbell
Kevin P. Campbell University of Iowa
Hiroyuki Sasaki
Hiroyuki Sasaki Jikei University School of Medicine
Eduardo Ríos
Eduardo Ríos Rush University
Robert T. Dirksen
Robert T. Dirksen University of Rochester

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