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Hiroshi Takeshima

Hiroshi Takeshima

D-Index & Metrics

Biology and Biochemistry

D-Index
86
Citations
27255
World Ranking
2956
National Ranking
185

Overview

Hiroshi Takeshima is affiliated with Kyoto University in Japan. Their research focuses primarily on the intersections of biochemistry, genetics, molecular biology, and medicine. The scientist has contributed extensively to the molecular biology subfield, with particular emphasis on ion channel regulation and related physiological processes.

The main research topics covered by Takeshima include:

  • Ion channel regulation and function
  • Ion transport and channel regulation
  • Cancer treatment and pharmacology
  • Metabolism, diabetes, and cancer
  • Cardiac electrophysiology and arrhythmias
  • Ion channels and receptors
  • Muscle physiology and disorders

Takeshima has published numerous papers with a focus on molecular mechanisms underlying cardiovascular and neurological conditions. Selected recent publications include:

  • "Predictive Value of the Cardio-Ankle Vascular Index for Cardiovascular Events in Patients at Cardiovascular Risk", 2021, Journal of the American Heart Association
  • "Parkinson's disease-associated ATP13A2/PARK9 functions as a lysosomal H+,K+-ATPase", 2023, Nature Communications
  • "Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-κB/cyclin D1 pathway", 2020, Nature Communications
  • "Calcium-induced calcium release and type 3 ryanodine receptors modulate the slow afterhyperpolarising current, sIAHP, and its potentiation in hippocampal pyramidal neurons", 2020, PLoS ONE
  • "Structure, Function, and Regulation of the Junctophilin Family", 2023, Annual Review of Physiology

The scientist has frequently collaborated with colleagues such as Miyuki Nishi, Atsuhiko Ichimura, Takuto Fujii, Takahiro Shimizu, and Yoshiaki Tabuchi, reflecting interdisciplinary teamwork in various research efforts.

Takeshima's research output has appeared in several well-known publication venues. These include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings for Annual Meeting of The Japanese Pharmacological Society
  • Nature Communications
  • PLoS ONE
  • iScience

Best Publications

  • Primary structure of the receptor for calcium channel blockers from skeletal muscle

    Tsutomu Tanabe;Hiroshi Takeshima;Atsushi Mikami;Veit Flockerzi

  • Primary structure and expression from complementary DNA of skeletal muscle ryanodine receptor.

    Hiroshi Takeshima;Seiichiro Nishimura;Takeshi Matsumoto;Hiroyuki Ishida

  • Primary structure and functional expression of the cardiac dihydropyridine-sensitive calcium channel

    Atsushi Mikami;Keiji Imoto;Tsutomu Tanabe;Tetsuhiro Niidome

  • Existence of distinct sodium channel messenger RNAs in rat brain

    Masaharu Noda;Takayuki Ikeda;Toshiaki Kayano;Harukazu Suzuki

  • Junctophilins: a novel family of junctional membrane complex proteins.

    Hiroshi Takeshima;Hiroshi Takeshima;Shinji Komazaki;Miyuki Nishi;Miyuki Nishi;Masamitsu Iino

  • TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

    Shinichiro Yamamoto;Shunichi Shimizu;Shigeki Kiyonaka;Nobuaki Takahashi

  • Expression of functional sodium channels from cloned cDNA

    Masaharu Noda;Takayuki Ikeda;Harukazu Suzuki;Hiroshi Takeshima

  • Spatiotemporal dynamics of inositol 1,4,5-trisphosphate that underlies complex Ca2+ mobilization patterns.

    Kenzo Hirose;Shiro Kadowaki;Mao Tanabe;Hiroshi Takeshima

  • cDNA cloning and regional distribution of a novel member of the opioid receptor family

    Kazuhiko Fukuda;Shigehisa Kato;Kenjiro Mori;Miyuki Nishi

  • Primary structure and distribution of a novel ryanodine receptor/calcium release channel from rabbit brain.

    Yasuhiro Hakamata;Junichi Nakai;Hiroshi Takeshima;Keiji Imoto

  • MG53 nucleates assembly of cell membrane repair machinery

    Chuanxi Cai;Haruko Masumiya;Noah Weisleder;Noriyuki Matsuda

  • Primary structure and functional expression from cDN A of the cardiac ryanodine receptor/calcium release channel

    Junichi Nakai;Toshiaki Imagawa;Yasuhiro Hakamata;Munekazu Shigekawa

  • Excitation-contraction uncoupling and muscular degeneration in mice lacking functional skeletal muscle ryanodine-receptor gene

    Takeshima H;Iino M;Takekura H;Nishi M

  • Primary structures and expression from cDNAs of rat opioid receptor δ-and μ-subtypes

    Kazuhiko Fukuda;Shigehisa Kato;Kenjiro Mori;Miyuki Nishi

  • Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors

    Toshiya Manabe;Yukihiro Noda;Takayoshi Mamiya;Hiroyuki Katagiri

  • Unrestrained nociceptive response and disregulation of hearing ability in mice lacking the nociceptin/orphaninFQ receptor

    Miyuki Nishi;Takeshi Houtani;Yukihiro Noda;Takayoshi Mamiya

  • Multiple types of ryanodine receptor/Ca2+ release channels are differentially expressed in rabbit brain

    T Furuichi;D Furutama;Y Hakamata;J Nakai

  • Molecular architecture of membranes involved in excitation-contraction coupling of cardiac muscle.

    Xin-Hui Sun;F. Protasi;M. Takahashi;H. Takeshima

  • Membrane Repair Defects in Muscular Dystrophy Are Linked to Altered Interaction between MG53, Caveolin-3, and Dysferlin

    Chuanxi Cai;Noah Weisleder;Jae-Kyun Ko;Shinji Komazaki

  • Embryonic lethality and abnormal cardiac myocytes in mice lacking ryanodine receptor type 2.

    Hiroshi Takeshima;Shinji Komazaki;Kenzo Hirose;Miyuki Nishi

Frequent Co-Authors

Miyuki Nishi
Miyuki Nishi Kyoto University
Jianjie Ma
Jianjie Ma The Ohio State University
Masamitsu Iino
Masamitsu Iino Nihon University
Tetsuo Noda
Tetsuo Noda Japanese Foundation For Cancer Research
Francesco Zorzato
Francesco Zorzato University of Ferrara
Susan Treves
Susan Treves University Hospital of Basel
Toshitaka Nabeshima
Toshitaka Nabeshima Meijo University
Shosaku Numa
Shosaku Numa Kyoto University
Yukihiro Noda
Yukihiro Noda Meijo University
Xiaoli Zhao
Xiaoli Zhao Tongji University

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