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Biology and Biochemistry

D-Index
56
Citations
20258
World Ranking
14159
National Ranking
1110

Overview

Christopher L. Carpenter is affiliated with GlaxoSmithKline (United Kingdom) and contributes to research in the United Kingdom. Their work spans several fields of study, predominantly Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology. Carpenter's research includes subfields such as Immunology, Genetics, Oncology, Pulmonary and Respiratory Medicine, and Surgery.

Their scientific investigations focus on a range of topics, including Immunotherapy and Immune Responses, Immune Cell Function and Interaction, Virus-based gene therapy research, CAR-T cell therapy research, Pleural and Pulmonary Diseases, Trauma Management and Diagnosis, and Ultrasound in Clinical Applications.

Prominent co-authors collaborating frequently with Carpenter include Douglas C. McLaughlin, Nicholas Bayhi, Sneha Pawar, Jennifer Mellen, and Laurence A. Turka.

Carpenter has published research in several peer-reviewed venues, appearing in journals such as Nature Communications, Cancer Immunology Immunotherapy, Journal of Ultrasound in Medicine, and Journal of Clinical Oncology.

  • Engineered red blood cells as an off-the-shelf allogeneic anti-tumor therapeutic, 2021, Nature Communications
  • Anti-tumor effects of RTX-240: an engineered red blood cell expressing 4-1BB ligand and interleukin-15, 2021, Cancer Immunology Immunotherapy
  • Novel Approach to Ultrasound-Guided Thoracostomy, 2021, Journal of Ultrasound in Medicine
  • Introduction of E-Score: A gene expression score to characterize immunogenic versus oncogenic HPV expression in HNSCC., 2023, Journal of Clinical Oncology

Carpenter's work reflects integration across multiple biological and clinical disciplines. Their research on engineered red blood cells addresses therapeutic approaches against tumors and immune modulation using novel cell-based strategies.

Another focus includes advancing diagnostic and interventional methods in pulmonary and respiratory medicine, as reflected in their work involving ultrasound-guided thoracostomy. The exploration of gene expression scores provides insights into oncogenic virus activity and its role in head and neck squamous cell carcinoma.

Their frequent involvement in immunotherapy and immune cell function underscores a commitment to understanding immune responses at molecular and clinical levels. Collaborative relationships with other researchers span similar interdisciplinary topics.

Best Publications

  • Oncogenes and signal transduction

    Lewis C Cantley;Kurt R Auger;Christopher Carpenter;Brian Duckworth

  • BVRI Light Curves for 22 Type Ia Supernovae

    Adam G. Riess;Robert P. Kirshner;Brian P. Schmidt;Saurabh Jha

  • BVRI Light Curves for 22 Type Ia Supernovae

    Adam G. Riess;Robert P. Kirshner;Brian P. Schmidt;Saurabh Jha

  • Thrombin receptor ligation and activated rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets

    John H. Hartwig;Gary M. Bokoch;Christopher L. Carpenter;Paul A. Janmey

  • Purification and characterization of phosphoinositide 3-kinase from rat liver.

    C L Carpenter;B C Duckworth;K R Auger;B Cohen

  • Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

    Hongbing Zhang;Gregor Cicchetti;Hiroaki Onda;Henry B. Koon

  • Rho Family GTPases Bind to Phosphoinositide Kinases

    Kimberley F. Tolias;Lewis C. Cantley;Christopher L. Carpenter;Christopher L. Carpenter

  • Rac Homologues and Compartmentalized Phosphatidylinositol 4, 5-Bisphosphate Act in a Common Pathway to Regulate Polar Pollen Tube Growth

    Benedikt Kost;Emmanuel Lemichez;Pius Spielhofer;Yan Hong

  • The poly(ADP-ribose) polymerase inhibitor niraparib (MK4827) in BRCA mutation carriers and patients with sporadic cancer: a phase 1 dose-escalation trial

    Shahneen K Sandhu;Shahneen K Sandhu;William R Schelman;George Wilding;Victor Moreno

  • BET inhibitor resistance emerges from leukaemia stem cells

    Chun Yew Fong;Omer Gilan;Omer Gilan;Enid Y N Lam;Alan Rubin

  • Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit.

    C. L. Carpenter;K. R. Auger;Manas Chanudhuri;M. Yoakim

  • A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 Inhibitors in SCLC.

    Helai P. Mohammad;Kimberly N. Smitheman;Chandrashekhar D. Kamat;David Soong

  • A Novel Link between Integrins, Transmembrane-4 Superfamily Proteins (CD63 and CD81), and Phosphatidylinositol 4-Kinase

    Fedor Berditchevski;Kimberly F. Tolias;Karen Wong;Christopher L. Carpenter

  • Rac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size.

    Abdelhafid Saci;Lewis C. Cantley;Christopher L. Carpenter

  • Type Iα phosphatidylinositol-4-phosphate 5-kinase mediates Rac-dependent actin assembly

    Kimberley F. Tolias;John H. Hartwig;John H. Hartwig;Hisamitsu Ishihara;Yoshikazu Shibasaki

  • The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin.

    K Lam;C L Carpenter;N B Ruderman;J C Friel

  • Correlation of PD-L1 Tumor Expression and Treatment Outcomes in Patients with Renal Cell Carcinoma Receiving Sunitinib or Pazopanib: Results from COMPARZ, a Randomized Controlled Trial

    Toni K. Choueiri;David J Figueroa;Andre P. Fay;Sabina Signoretti

  • A tightly associated serine/threonine protein kinase regulates phosphoinositide 3-kinase activity.

    C. L. Carpenter;K. R. Auger;B. C. Duckworth;Wei-Min Hou

  • Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42

    Rikki Kolluri;Kimberley Fuchs Tolias;Christopher L. Carpenter;Fred S. Rosen

  • BTK Regulates PtdIns-4,5-P2 Synthesis: Importance for Calcium Signaling and PI3K Activity

    Kan Saito;Kimberley F. Tolias;Abdelhafid Saci;Henry B. Koon

Frequent Co-Authors

Lewis C. Cantley
Lewis C. Cantley Harvard University
Rab K. Prinjha
Rab K. Prinjha GlaxoSmithKline (United Kingdom)
Toni K. Choueiri
Toni K. Choueiri Harvard University
John H. Hartwig
John H. Hartwig Brigham and Women's Hospital
Robert J. Motzer
Robert J. Motzer Memorial Sloan Kettering Cancer Center
Toby Johnson
Toby Johnson Queen Mary University of London
Brian Schaffhausen
Brian Schaffhausen Tufts University
George Wilding
George Wilding University of Wisconsin–Madison
Anthony W. Tolcher
Anthony W. Tolcher Texas Oncology
Ricky W. Johnstone
Ricky W. Johnstone Peter MacCallum Cancer Centre

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