World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
42
Citations
8306
World Ranking
19464
National Ranking
1505

Overview

J J Reynolds is affiliated with King's College London in the United Kingdom. Their primary field of study is Biochemistry, Genetics and Molecular Biology, with a focus that spans several subfields including Molecular Biology, Plant Science, Genetics, Oncology, and Cancer Research.

Their research topics encompass various aspects of genetic and molecular mechanisms, particularly with a concentration on DNA Repair Mechanisms, Genomics and Chromatin Dynamics, RNA Research and Splicing, Chromosomal and Genetic Variations, CRISPR and Genetic Engineering, Epigenetics and DNA Methylation, and Carcinogens and Genotoxicity Assessment.

Reynolds has contributed to multiple research papers published in notable scientific journals. Recent publications include:

  • "DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain" (2020, Nature Communications)
  • "RECON syndrome is a genome instability disorder caused by mutations in the DNA helicase RECQL1" (2022, Journal of Clinical Investigation)
  • "Pathogenic variants in SLF2 and SMC5 cause segmented chromosomes and mosaic variegated hyperploidy" (2022, Nature Communications)
  • "Excessive transcription-replication conflicts are a vulnerability of BRCA1-mutant cancers" (2023, Nucleic Acids Research)
  • "RNF8 ubiquitylation of XRN2 facilitates R-loop resolution and restrains genomic instability in BRCA1 mutant cells" (2023, Nucleic Acids Research)

Their frequent co-authors include:

  • Grant S. Stewart
  • Gavin S. McNee
  • Satpal S. Jhujh
  • Andrew P. Jackson
  • Parasvi S. Patel

J J Reynolds has published predominantly in the following venues:

  • Nucleic Acids Research (3 publications)
  • Nature Communications (2 publications)
  • Journal of Clinical Investigation (1 publication)
  • bioRxiv (Cold Spring Harbor Laboratory) (1 publication)
  • UNC Libraries (1 publication)

Best Publications

  • Comparison of human stromelysin and collagenase by cloning and sequence analysis

    S E Whitham;G Murphy;P Angel;H J Rahmsdorf

  • Purification of rabbit bone inhibitor of collagenase.

    T E Cawston;W A Galloway;E Mercer;G Murphy

  • Binding of gelatinases A and B to type-I collagen and other matrix components.

    J A Allan;A J P Docherty;P J Barker;N S Huskisson

  • Characterization of gelatinase from pig polymorphonuclear leucocytes. A metalloproteinase resembling tumour type IV collagenase.

    G Murphy;R Ward;R M Hembry;J J Reynolds

  • Evidence that latent collagenases are enzyme-inhibitor complexes.

    A Sellers;E Cartwright;G Murphy;J J Reynolds

  • Partial purification of collagenase and gelatinase from human polymorphonuclear leucocytes. Analysis of their actions on soluble and insoluble collagens.

    G Murphy;J J Reynolds;U Bretz;M Baggiolini

  • Biosynthesis of tissue inhibitor of metalloproteinases by human fibroblasts in culture. Stimulation by 12-O-tetradecanoylphorbol 13-acetate and interleukin 1 in parallel with collagenase.

    G Murphy;J J Reynolds;Z Werb

  • Purification and characterization of a rabbit bone metalloproteinase that degrades proteoglycan and other connective-tissue components.

    W A Galloway;G Murphy;J D Sandy;J Gavrilovic

  • The interaction of purified rabbit bone collagenase with purified rabbit bone metalloproteinase inhibitor.

    T E Cawston;G Murphy;E Mercer;W A Galloway

  • An inhibitor of collagenase from human amniotic fluid. Purification, characterization and action on metalloproteinases

    G Murphy;T E Cawston;J J Reynolds

  • Collagenase is a component of the specific granules of human neutrophil leucocytes.

    G Murphy;J J Reynolds;U Bretz;M Baggiolini

  • Stimulation by endocytosis of the secretion of collagenase and neutral proteinase from rabbit synovial fibroblasts.

    Zena Werb;John J. Reynolds

  • The effects of selective inhibitors of matrix metalloproteinases (MMPs) on bone resorption and the identification of MMPs and TIMP-1 in isolated osteoclasts

    P. A. Hill;G. Murphy;A. J. P. Docherty;R. M. Hembry

  • The purification of tissue inhibitor of metalloproteinases-2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases-2 and tissue inhibitor of metalloproteinases-1.

    R V Ward;R M Hembry;J J Reynolds;G Murphy

  • The latent collagenase and gelatinase of human polymorphonuclear neutrophil leucocytes.

    G Murphy;U Bretz;M Baggiolini;J J Reynolds

  • Neutral metallo-proteinases of rabbit bone. Separation in latent forms of distinct enzymes that when activated degrade collagen, gelatin and proteoglycans.

    A Sellers;J J Reynolds;M C Meikle

  • Human osteoblasts in culture synthesize collagenase and other matrix metalloproteinases in response to osteotropic hormones and cytokines

    M.C. Meikle;S. Bord;R.M. Hembry;J. Compston

  • BOD1L Is Required to Suppress Deleterious Resection of Stressed Replication Forks.

    Martin R. Higgs;John J. Reynolds;Alicja Winczura;Andrew N. Blackford

  • Metalloproteinases from rabbit bone culture medium degrade types IV and V collagens, laminin and fibronectin

    G Murphy;T E Cawston;W A Galloway;M J Barnes

  • Immunolocalization of tissue inhibitor of metalloproteinases (TIMP) in human cells. Characterization and use of a specific antiserum

    R.M. Hembry;G. Murphy;J.J. Reynolds

Frequent Co-Authors

Gillian Murphy
Gillian Murphy University of Cambridge
Rosalind M. Hembry
Rosalind M. Hembry University of East Anglia
Grant S. Stewart
Grant S. Stewart University of Birmingham
Zena Werb
Zena Werb University of California, San Francisco
R. G. G. Russell
R. G. G. Russell University of Sheffield
Ian N. Bruce
Ian N. Bruce University of Manchester
Andrew P. Jackson
Andrew P. Jackson University of Edinburgh
Keith W. Caldecott
Keith W. Caldecott University of Sussex
Christopher A. Walsh
Christopher A. Walsh Howard Hughes Medical Institute
Andrew J. P. Docherty
Andrew J. P. Docherty UCB Pharma (Belgium)

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