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Medicine

D-Index
94
Citations
42197
World Ranking
10311
National Ranking
993

Overview

R. G. G. Russell is affiliated with the University of Sheffield in the United Kingdom and has contributed extensively to the field of medicine, with a particular focus on bone health and related treatments. Their research spans multiple subfields, including oncology, surgery, radiology, nuclear medicine and imaging, molecular biology, and orthopedics and sports medicine.

The scientist has authored numerous papers addressing key topics such as bone health and treatments, radiopharmaceutical chemistry and applications, osteoporosis research, orthopedic infections and treatments, telomeres, telomerase and senescence, bone and joint diseases, and mechanisms involving neutrophils, myeloperoxidase, and oxidative processes.

Frequent co-authors of R. G. G. Russell include Frank H. Ebetino, Shuting Sun, Philip Cherian, Jeffrey D. Neighbors, and Parish P. Sedghizadeh, reflecting collaboration across a range of studies.

Key publication venues for their research are:

  • Bone
  • British Journal of Pharmacology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Aging
  • Scientific Reports

Some recent publications demonstrate the scope and timeline of their work:

  • "Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use," 2021, Bone
  • "Zoledronate," 2020, Bone
  • "History of alendronate," 2020, Bone
  • "Bisphosphonates for delivering drugs to bone," 2020, British Journal of Pharmacology
  • "In vitro and in vivo effects of zoledronic acid on senescence and senescence-associated secretory phenotype markers," 2023, Aging

R. G. G. Russell's work contributes to understanding the chemistry and biological activity of bisphosphonates, a class of drugs targeting bone metabolism, with implications for therapies addressing bone density and related disorders. Their research also extends into drug delivery methods and the cellular mechanisms involved in bone health and aging processes.

Best Publications

  • The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

    Christina Curtis;Christina Curtis;Sohrab P Shah;Suet-Feung Chin;Gulisa Turashvili

  • Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy

    R. G. G. Russell;N. B. Watts;F. H. Ebetino;M. J. Rogers

  • The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes

    Bernard Pereira;Suet Feung Chin;Oscar M. Rueda;Hans Kristian Moen Vollan

  • Novel insights into actions of bisphosphonates on bone: Differences in interactions with hydroxyapatite

    G.H. Nancollas;R. Tang;R.J. Phipps;Z. Henneman

  • Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro

    J. E. Fisher;M. J. Rogers;J. M. Halasy;S. P. Luckman

  • Intestinal label-retaining cells are secretory precursors expressing Lgr5

    Simon J. A. Buczacki;Heather Ireland Zecchini;Anna M. Nicholson;Roslin Russell

  • Production of collagenase and prostaglandins by isolated adherent rheumatoid synovial cells

    J M Dayer;S M Krane;R G Russell;D R Robinson

  • Effect of ethane-1-hydroxy-1,1-diphosphonate (EHDP) and dichloromethylene diphosphonate (Cl 2 MDP) on the calcification and resorption of cartilage and bone in the tibial epiphysis and metaphysis of rats.

    R. Schenk;W. A. Merz;R. Mühlbauer;R. G. G. Russell

  • The molecular mechanism of nitrogen-containing bisphosphonates as antiosteoporosis drugs.

    K. L. Kavanagh;K. Guo;James Edward Dunford;James Edward Dunford;James Edward Dunford;X. Wu

  • Production of osteocalcin by human bone cells in vitro. Effects of 1,25(OH)2D3, 24,25(OH)2D3, parathyroid hormone, and glucocorticoids

    J.N. Beresford;J.A. Gallagher;J.W Poser;R.G.G. Russell

  • Molecular mechanisms of action of bisphosphonates.

    M.J Rogers;J.C Frith;J.C Frith;S.P Luckman;S.P Luckman;F.P Coxon;F.P Coxon

  • Bisphosphonates from bench to bedside

    R. G. G. Russell

  • Bisphosphonates: an update on mechanisms of action and how these relate to clinical efficacy.

    R. G. G. Russell;Z. Xia;J. E. Dunford;U. Oppermann

  • Inhibition of osteoclast-like cell formation by bisphosphonates in long-term cultures of human bone marrow.

    D. E. Hughes;B. R. Macdonald;R. G. G. Russell;M. Gowen

  • The influence of pyrophosphate, condensed phosphates, phosphonates and other phosphate compounds on the dissolution of hydroxyapatite in vitro and on bone resorption induced by parathyroid hormone in tissue culture and in thyroparathyroidectomised rats.

    R. G. G. Russell;R. C. Mühlbauer;S. Bisaz;D. A. Williams

  • The Inhibitory Effect of Phosphonates on the Formation of Calcium Phosphate Crystals in vitro and on Aortic and Kidney Calcification in vivo

    H. A. Fleisch;R. G. G. Russell;S. Bisaz;R. C. Mühlbauer

  • The pharmacology of bisphosphonates and new insights into their mechanisms of action

    R G G Russell;M J Rogers;J C Frith;S P Luckman;S P Luckman

  • Bisphosphonates: pharmacology, mechanisms of action and clinical uses.

    R. G. G. Russell;P. I. Croucher;M. J. Rogers

  • Inorganic pyrophosphate in plasma in normal persons and in patients with hypophosphatasia, osteogenesis imperfecta, and other disorders of bone

    R. G. G. Russell;S. Bisaz;A. Donath;D. B. Morgan

  • Estrogen inhibits release of tumor necrosis factor from peripheral blood mononuclear cells in postmenopausal women.

    S. H. Ralston;R. G. G. Russell;M. Gowen

Frequent Co-Authors

Herbert Fleisch
Herbert Fleisch University of Bern
Carlos Caldas
Carlos Caldas University of Cambridge
Michael J. Rogers
Michael J. Rogers Garvan Institute of Medical Research
Ian G. Mills
Ian G. Mills University of Oxford
John A. Kanis
John A. Kanis Australian Catholic University
David E. Neal
David E. Neal University of Cambridge
Ian O. Ellis
Ian O. Ellis University of Nottingham
Richard Eastell
Richard Eastell University of Sheffield
Gillian Murphy
Gillian Murphy University of Cambridge
James T. Triffitt
James T. Triffitt University of Oxford

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