Andrew J. P. Docherty

Overview

Best Publications

• Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor.

  D. R. Edwards;G. Murphy;J. J. Reynolds;S. E. Whitham

  1549
  Citations

• Sequence of human tissue inhibitor of metalloproteinases and its identity to erythroid-potentiating activity

  Andrew J. P. Docherty;Alan Lyons;Bryan J. Smith;Edwina M. Wright

  1017
  Citations

• The matrix metalloproteinases and their inhibitors.

  Gillian Murphy;Andrew J. P. Docherty

  840
  Citations

• TNF-α converting enzyme (TACE) is inhibited by TIMP-3

  Augustin Amour;Patrick M Slocombe;Ailsa Webster;Michael Butler

  821
  Citations

• Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 95 kDa and 72 kDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinase (PUMP).

  G Murphy;M I Cockett;R V Ward;A J P Docherty

  659
  Citations

• Stromelysin is an activator of procollagenase. A study with natural and recombinant enzymes.

  G Murphy;M I Cockett;P E Stephens;B J Smith

  658
  Citations

• Comparison of human stromelysin and collagenase by cloning and sequence analysis

  S E Whitham;G Murphy;P Angel;H J Rahmsdorf

  612
  Citations

• The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3.

  Augustin Amour;C.Graham Knight;Ailsa Webster;Patrick M. Slocombe

  525
  Citations

• The N-terminal domain of tissue inhibitor of metalloproteinases retains metalloproteinase inhibitory activity.

  Gillian Murphy;Annick Houbrechts;Mark I. Cockett;Richard A. Williamson

  458
  Citations

• The role of the C-terminal domain in collagenase and stromelysin specificity.

  G Murphy;J A Allan;F Willenbrock;M I Cockett

  435
  Citations

• The C-terminal domain of 72 kDa gelatinase A is not required for catalysis, but is essential for membrane activation and modulates interactions with tissue inhibitors of metalloproteinases

  G. Murphy;F. Willenbrock;R. V. Ward;M. I. Cockett

  389
  Citations

• Binding of gelatinases A and B to type-I collagen and other matrix components.

  J A Allan;A J P Docherty;P J Barker;N S Huskisson

  374
  Citations

• TISSUE INHIBITOR OF METALLOPROTEINASE-2 (TIMP-2) BINDS TO THE CATALYTIC DOMAIN OF THE CELL SURFACE RECEPTOR, MEMBRANE TYPE 1-MATRIX METALLOPROTEINASE 1 (MT1-MMP)

  Stanley Zucker;Stanley Zucker;Michelle Drews;Cathleen Conner;Hussein D. Foda;Hussein D. Foda

  362
  Citations

• Regulation of matrix metalloproteinase activity.

  Gillian Murphy;Frances Willenbrock;Thomas Crabbe;Mark O'shea

  313
  Citations

• Assessment of the role of the fibronectin-like domain of gelatinase A by analysis of a deletion mutant.

  G. Murphy;Quang Nguyen;M. I. Cockett;S. J. Atkinson

  296
  Citations

• Tissue inhibitor of metalloproteinases-2 inhibits the activation of 72 kDa progelatinase by fibroblast membranes

  Robin V. Ward;Susan J. Atkinson;Patrick M. Slocombe;Andrew J.P. Docherty

  283
  Citations

• The activity of the tissue inhibitors of metalloproteinases is regulated by C-terminal domain interactions: a kinetic analysis of the inhibition of gelatinase A.

  Frances Willenbrock;Thomas Crabbe;Patrick M. Slocombe;Chris W. Sutton

  283
  Citations

• Interaction of metargidin (ADAM-15) with alphavbeta3 and alpha5beta1 integrins on different haemopoietic cells.

  D. Nath;P. M. Slocombe;P. E. Stephens;A. Warn

  280
  Citations

• The matrix metalloproteinases and their natural inhibitors: prospects for treating degenerative tissue diseases

  Andrew J.P. Docherty;James O'Connell;Tom Crabbe;Sarojani Angal

  280
  Citations

• Meltrin gamma(ADAM-9) mediates cellular adhesion through alpha(6)beta(1 )integrin, leading to a marked induction of fibroblast cell motility.

  D. Nath;P.M. Slocombe;A. Webster;P.E. Stephens

  273
  Citations