Harald Tschesche

Overview

Best Publications

• Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage.

  R C Billinghurst;L Dahlberg;M Ionescu;A Reiner

  1462
  Citations

• Matrix metalloproteinase-8 is expressed in rheumatoid synovial fibroblasts and endothelial cells - Regulation by tumor necrosis factor-alpha and doxycycline

  Roeland Hanemaaijer;Timo Sorsa;Yrjö T. Konttinen;Yanli Ding

  612
  Citations

• The X-ray crystal structure of the catalytic domain of human neutrophil collagenase inhibited by a substrate analogue reveals the essentials for catalysis and specificity.

  W Bode;P Reinemer;R Huber;T Kleine

  468
  Citations

• Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor

  Carlos Fernandez‐Catalan;Wolfram Bode;Robert Huber;Dusan Turk

  451
  Citations

• Structural properties of matrix metalloproteinases

  W Bode;C Fernandez-Catalan;Harald Tschesche;F Grams

  447
  Citations

• MATRIX METALLOPROTEINASES AND THEIR INHIBITORS IN GINGIVAL CREVICULAR FLUID AND SALIVA OF PERIODONTITIS PATIENTS

  Tuula Ingman;Taina Tervahartiala;Yanli Ding;Harald Tschesche

  438
  Citations

• Unusual solution properties of proline and its interaction with proteins.

  Brigitte Schobert;Harald Tschesche

  417
  Citations

• A 25 kDa α2‐microglobulin‐related protein is a component of the 125 kDa form of human gelatinase

  Susanne Triebel;Jörg Bläser;Heinz Reinke;Harald Tschesche

  337
  Citations

• Interleukin-8 synthesis and the onset of labor

  Rgw Osmers;J Blaser;W Kuhn;Harald Tschesche

  309
  Citations

• Insights into MMP-TIMP interactions.

  Wolfram Bode;Carlos Fernandez-Catalan;Frank Grams;Franz-Xaver Gomis-Rüth

  287
  Citations

• Activation of Type IV Procollagenases by Human Tumor-associated Trypsin-2*

  Timo Sorsa;Tuula Salo;Erkki Koivunen;Jaana Tyynelä

  257
  Citations

• X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug design.

  Frank Grams;Peter Reinemer;James C. Powers;Thomas Kleine

  251
  Citations

• Origin of cervical collagenase during parturition

  R Osmers;W Rath;BC Adelmann-Grill;C Fittkow

  249
  Citations

• Structure determination and analysis of human neutrophil collagenase complexed with a hydroxamate inhibitor

  Frank Grams;Mike Crimmin;Laurie Hinnes;Philip Huxley

  232
  Citations

• Oxygen radicals as effectors of cartilage destruction. Direct degradative effect on matrix components and indirect action via activation of latent collagenase from polymorphonuclear leukocytes.

  H Burkhardt;M Schwingel;H Menninger;Hw Macartney

  221
  Citations

• Tissue inhibitor of metalloproteinase (TIMP)-2 acts synergistically with synthetic matrix metalloproteinase (MMP) inhibitors but not with TIMP-4 to enhance the (Membrane type 1)-MMP-dependent activation of pro-MMP-2.

  Marta Toth;M. Margarida Bernardo;David C. Gervasi;Paul D. Soloway

  199
  Citations

• Direct activation of human neutrophil procollagenase by recombinant stromelysin

  V Knäuper;S M Wilhelm;P K Seperack;Y A DeClerck

  196
  Citations

• Structural implications for the role of the N terminus in the 'superactivation' of collagenases. A crystallographic study.

  Peter Reinemer;Frank Grams;Robert Huber;Thomas Kleine

  195
  Citations

• Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain.

  A J Fosang;V Knäuper;P J Neame

  193
  Citations

• Clinical evidence for a protective role of lipocalin-2 against MMP-9 autodegradation and the impact for gastric cancer

  Frank J.G.M. Kubben;Cornelis F.M. Sier;Lukas J.A.C. Hawinkels;Harald Tschesche

  190
  Citations