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D-Index & Metrics

Biology and Biochemistry

D-Index
47
Citations
7806
World Ranking
18722
National Ranking
1284

Overview

Klaus Maskos is affiliated with Proteros biostructures GmbH in Germany. Their research primarily falls within the field of Medicine, with a particular emphasis on Infectious Diseases, Molecular Biology, Computational Theory and Mathematics, Genetics, and Radiology, Nuclear Medicine and Imaging.

The scientist's work covers several main topics, including:

  • SARS-CoV-2 and COVID-19 Research
  • Computational Drug Discovery Methods
  • Chronic Lymphocytic Leukemia Research
  • Biochemical and Molecular Research
  • Protein Degradation and Inhibitors
  • Neuroendocrine Tumor Research Advances
  • Inflammatory mediators and NSAID effects

Maskos has published in a variety of scientific venues with frequency in:

  • Journal of Medicinal Chemistry
  • Bioorganic & Medicinal Chemistry
  • Antiviral Research
  • SSRN Electronic Journal
  • ACS Medicinal Chemistry Letters

Recent publications by Klaus Maskos include:

  • Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry, 2021, Bioorganic & Medicinal Chemistry
  • Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH, 2024, Journal of Medicinal Chemistry
  • Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV-2 Mpro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronavirus Homologues and Nirmatrelvir-Resistant Variants, 2024, Journal of Medicinal Chemistry
  • Biological characterization of AB-343, a novel and potent SARS-CoV-2 Mpro inhibitor with pan-coronavirus activity, 2024, Antiviral Research
  • Biological Characterization of Ab-343, a Novel and Potent Sars-Cov-2 Mpro Inhibitor with Pan-Coronavirus Activity, 2024, SSRN Electronic Journal

The scientist frequently collaborates with a group of coauthors, which includes:

  • Débora L. Makino
  • Andreas Bergmann
  • Alfred Lammens
  • Dimitar Gotchev
  • Kristi Fan

Best Publications

  • Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1.

    Franz-Xaver Gomis-Rüth;Klaus Maskos;Michael Betz;Andreas Bergner

  • Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme.

    Klaus Maskos;Carlos Fernandez-Catalan;Robert Huber;Gleb P. Bourenkov

  • Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor

    Carlos Fernandez‐Catalan;Wolfram Bode;Robert Huber;Dusan Turk

  • Structural properties of matrix metalloproteinases

    W Bode;C Fernandez-Catalan;Harald Tschesche;F Grams

  • Insights into MMP-TIMP interactions.

    Wolfram Bode;Carlos Fernandez-Catalan;Frank Grams;Franz-Xaver Gomis-Rüth

  • Crystal structures of MMPs in complex with physiological and pharmacological inhibitors.

    Klaus Maskos

  • Structural basis of the matrix metalloproteinases and their physiological inhibitors, the tissue inhibitors of metalloproteinases.

    Wolfram Bode;Klaus Maskos

  • Crystal Structures of MMP-9 Complexes with Five Inhibitors: Contribution of the Flexible Arg424 Side-chain to Selectivity

    Anna Tochowicz;Klaus Maskos;Robert Huber;Ruth Oltenfreiter

  • A novel strategy for inhibition of α-amylases: yellow meal worm α-amylase in complex with the Ragi bifunctional inhibitor at 2.5 å resolution

    Stefan Strobl;Klaus Maskos;Georg Wiegand;Robert Huber

  • Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers

    Samuel W. Gerritz;Christopher Cianci;Sean Kim;Bradley C. Pearce

  • The Structure of CDK8/CycC Implicates Specificity in the CDK/Cyclin Family and Reveals Interaction with a Deep Pocket Binder

    E. V. Schneider;J. Böttcher;M. Blaesse;L. Neumann

  • Crystal structure of yellow meal worm alpha-amylase at 1.64 A resolution.

    S Strobl;K Maskos;M Betz;G Wiegand

  • Structure-kinetic relationship study of CDK8/CycC specific compounds.

    Elisabeth V. Schneider;Jark Böttcher;Robert Huber;Klaus Maskos

  • Structural basis of matrix metalloproteinases and tissue inhibitors of metalloproteinases.

    Klaus Maskos;Wolfram Bode

  • X-ray structure of human proMMP-1: new insights into procollagenase activation and collagen binding.

    Daniela Jozic;Gleb Bourenkov;Ngee-Han Lim;Robert Visse

  • Three-dimensional structure of human tissue inhibitor of metalloproteinases-2 at 2.1 A resolution.

    Ari Tuuttila;Ekaterina Morgunova;Ulrich Bergmann;Ylva Lindqvist

  • Substrate specificity determinants of human macrophage elastase (MMP-12) based on the 1.1 A crystal structure.

    Rupert Lang;Andreas Kocourek;Marianne Braun;Harald Tschesche

  • DsbA and DsbC-catalyzed oxidative folding of proteins with complex disulfide bridge patterns in vitro and in vivo.

    Klaus Maskos;Martina Huber-Wunderlich;Rudi Glockshuber

  • Eukaryotic expression: developments for structural proteomics.

    A R Aricescu;R Assenberg;R M Bill;D Busso

  • Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex.

    Magdalena Wisniewska;Peter Goettig;Klaus Maskos;Edward Belouski

Frequent Co-Authors

Wolfram Bode
Wolfram Bode Max Planck Society
Robert Huber
Robert Huber University of Duisburg-Essen
Roy A. Black
Roy A. Black Amgen (United States)
Hideaki Nagase
Hideaki Nagase University of Oxford
Robert Huber
Robert Huber Agricultural & Applied Economics Association
Harald Tschesche
Harald Tschesche Bielefeld University
Gillian Murphy
Gillian Murphy University of Cambridge
Vera Knäuper
Vera Knäuper Cardiff University
Pascal Schneider
Pascal Schneider University of Lausanne

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