Member of the European Molecular Biology Organization (EMBO)
Fellow of The Academy of Medical Sciences, United Kingdom
Keith W. Caldecott spends much of his time researching DNA repair, Molecular biology, DNA, DNA ligase and DNA damage. His DNA repair research focuses on Nucleotide excision repair in particular. His Nucleotide excision repair research is multidisciplinary, incorporating perspectives in Base excision repair and Replication protein A.
Keith W. Caldecott performs multidisciplinary studies into Molecular biology and XRCC1 in his work. In his study, which falls under the umbrella issue of DNA, Aprataxin is strongly linked to Cell biology. His DNA ligase research entails a greater understanding of Biochemistry.
Keith W. Caldecott spends much of his time researching DNA repair, DNA, Molecular biology, Cell biology and DNA damage. He incorporates DNA repair and XRCC1 in his research. His study in the field of Topoisomerase and Aprataxin also crosses realms of DNA Single Strand Break.
His studies in Molecular biology integrate themes in fields like Base excision repair, Nucleotide excision repair, DNA repair protein XRCC4, Mutation and DNA ligase. His Cell biology research is multidisciplinary, relying on both Chromatin, DNA Strand Break and Poly ADP ribose polymerase, PARP1. His research in DNA damage tackles topics such as DNA replication which are related to areas like Genome.
The scientist’s investigation covers issues in Cell biology, DNA, PARP1, DNA repair and XRCC1. The various areas that Keith W. Caldecott examines in his Cell biology study include Transcription, Poly ADP ribose polymerase and DNA Strand Break, DNA damage. His DNA damage research focuses on subjects like DNA polymerase, which are linked to DNA synthesis and DNA ligase.
His work on Topoisomerase as part of general DNA study is frequently linked to DNA Single Strand Break, bridging the gap between disciplines. His research integrates issues of Okazaki fragments, Cerebellar ataxia and DNA replication in his study of PARP1. His research on DNA repair often connects related topics like Ribosomal RNA.
His primary areas of investigation include DNA, Cell biology, DNA repair, PARP1 and DNA damage. His research in DNA is mostly concerned with Topoisomerase. His studies deal with areas such as Chromosome breakage, Chromosomal translocation, Chromatin, Cohesin and Poly ADP ribose polymerase as well as DNA repair.
His Poly ADP ribose polymerase study incorporates themes from BRCT domain, Base excision repair, LIG1 and Flap endonuclease. His PARP1 research includes elements of Okazaki fragments and DNA replication. His DNA damage study is focused on Genetics in general.
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Single-strand break repair and genetic disease
Keith W. Caldecott.
Nature Reviews Genetics (2008)
XRCC1 Polypeptide Interacts with DNA Polymerase β and Possibly Poly (ADP-Ribose) Polymerase, and DNA Ligase III Is a Novel Molecular ‘Nick-Sensor’ In Vitro
Keith W. Caldecott;Said Aoufouchi;Penny Johnson;Sydney Shall.
Nucleic Acids Research (1996)
XRCC1 and DNA strand break repair.
Keith W. Caldecott.
DNA Repair (2003)
A requirement for PARP‐1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage
Sherif F. El‐Khamisy;Mitsuko Masutani;Hiroshi Suzuki;Keith W. Caldecott.
Nucleic Acids Research (2003)
XRCC1 Stimulates Human Polynucleotide Kinase Activity at Damaged DNA Termini and Accelerates DNA Single-Strand Break Repair
Claire J Whitehouse;Richard M Taylor;Angela Thistlethwaite;Hong Zhang.
Involvement of XRCC1 and DNA Ligase III Gene Products in DNA Base Excision Repair
Enrico Cappelli;Richard Taylor;Michela Cevasco;Angelo Abbondandolo.
Journal of Biological Chemistry (1997)
Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1
Sherif F. El-Khamisy;Gulam M. Saifi;Michael Weinfeld;Fredrik Johansson.
The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates
Ivan Ahel;Ulrich Rass;Sherif F. El-Khamisy;Sherif F. El-Khamisy;Sachin Katyal.
A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage
Felipe Cortes Ledesma;Sherif F. El Khamisy;Sherif F. El Khamisy;Maria C. Zuma;Kay Osborn.
Spatial and temporal cellular responses to single-strand breaks in human cells.
Satoshi Okano;Li Lan;Keith W. Caldecott;Toshio Mori.
Molecular and Cellular Biology (2003)
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