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Molecular Biology

D-Index
80
Citations
23141
World Ranking
1000
National Ranking
76

Research.com Recognitions

  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Keith W. Caldecott is affiliated with the University of Sussex in the United Kingdom. Their research primarily focuses on the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these broader fields, their work explores subfields including Molecular Biology, Oncology, Genetics, Infectious Diseases, and Plant Science.

Their main areas of study center on DNA Repair Mechanisms, PARP inhibition in cancer therapy, CRISPR and Genetic Engineering, Genomics and Chromatin Dynamics, Cancer therapeutics and mechanisms, RNA Research and Splicing, and Polyomavirus and related diseases.

Recent publications include the following papers:

  • "Neuronal enhancers are hotspots for DNA single-strand break repair," 2021, Nature
  • "XRCC1 prevents toxic PARP1 trapping during DNA base excision repair," 2021, Molecular Cell
  • "DNA single-strand break repair and human genetic disease," 2022, Trends in Cell Biology
  • "PARP inhibition impedes the maturation of nascent DNA strands during DNA replication," 2022, Nature Structural & Molecular Biology
  • "The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling," 2021, Journal of Biological Chemistry

Frequent co-authors of Keith W. Caldecott include Hana Hanzlíková, Jan Bražina, Richard Hailstone, Kamila Burdová, and Michael E. Ward.

Key publication venues for this researcher comprise bioRxiv (Cold Spring Harbor Laboratory), DNA Repair, Molecular Cell, Nature, and Nucleic Acids Research.

The scientist has been recognized with awards such as Fellow of The Academy of Medical Sciences, United Kingdom, and membership in the European Molecular Biology Organization (EMBO).

Best Publications

  • Single-strand break repair and genetic disease

    Keith W. Caldecott

  • XRCC1 Polypeptide Interacts with DNA Polymerase β and Possibly Poly (ADP-Ribose) Polymerase, and DNA Ligase III Is a Novel Molecular ‘Nick-Sensor’ In Vitro

    Keith W. Caldecott;Said Aoufouchi;Penny Johnson;Sydney Shall

  • XRCC1 and DNA strand break repair.

    Keith W. Caldecott

  • A requirement for PARP‐1 for the assembly or stability of XRCC1 nuclear foci at sites of oxidative DNA damage

    Sherif F. El‐Khamisy;Mitsuko Masutani;Hiroshi Suzuki;Keith W. Caldecott

  • XRCC1 Stimulates Human Polynucleotide Kinase Activity at Damaged DNA Termini and Accelerates DNA Single-Strand Break Repair

    Claire J Whitehouse;Richard M Taylor;Angela Thistlethwaite;Hong Zhang

  • An interaction between the mammalian DNA repair protein XRCC1 and DNA ligase III.

    Keith W. Caldecott;Catherine K. McKeown;James D. Tucker;Siv Ljungquist

  • Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

    Sherif F. El-Khamisy;Gulam M. Saifi;Michael Weinfeld;Fredrik Johansson

  • A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

    Felipe Cortes Ledesma;Sherif F. El Khamisy;Sherif F. El Khamisy;Maria C. Zuma;Kay Osborn

  • Involvement of XRCC1 and DNA Ligase III Gene Products in DNA Base Excision Repair

    Enrico Cappelli;Richard Taylor;Michela Cevasco;Angelo Abbondandolo

  • The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates

    Ivan Ahel;Ulrich Rass;Sherif F. El-Khamisy;Sherif F. El-Khamisy;Sachin Katyal

  • Spatial and temporal cellular responses to single-strand breaks in human cells.

    Satoshi Okano;Li Lan;Keith W. Caldecott;Toshio Mori

  • Characterization of the XRCC1-DNA ligase III complex in vitro and its absence from mutant hamster cells

    Keith W. Caldecott;James D. Tucker;Lawrence H. Stanker;Larry H. Thompson

  • DNA strand break repair and human genetic disease.

    Peter J. McKinnon;Keith W. Caldecott

  • The Importance of Poly(ADP-Ribose) Polymerase as a Sensor of Unligated Okazaki Fragments during DNA Replication

    Hana Hanzlikova;Ilona Kalasova;Annie A. Demin;Lewis E. Pennicott

  • XRCC1 protein interacts with one of two distinct forms of DNA ligase III.

    Rachel A. Nash;Keith W. Caldecott;Deborah E. Barnes;Tomas Lindahl

  • The Protein Kinase CK2 Facilitates Repair of Chromosomal DNA Single-Strand Breaks

    Joanna I. Loizou;Sherif F. El-Khamisy;Anastasia Zlatanou;David J. Moore

  • Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner

    Jill Moser;Hanneke Kool;Ioannis Giakzidis;Keith Caldecott

  • Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase.

    Anna E. O. Fisher;Helfrid Hochegger;Shunichi Takeda;Keith W. Caldecott

  • PARP-3 and APLF function together to accelerate nonhomologous end joining

    Stuart L. Rulten;Anna E.O. Fisher;Isabelle Robert;Maria C. Zuma

  • Mutations in PNKP cause microcephaly, seizures and defects in DNA repair

    Jun Shen;Edward C Gilmore;Edward C Gilmore;Christine A Marshall;Mary Haddadin

Frequent Co-Authors

Peter J. McKinnon
Peter J. McKinnon St. Jude Children's Research Hospital
Thomas Helleday
Thomas Helleday Karolinska Institute
Laurence H. Pearl
Laurence H. Pearl University of Sussex
Christopher A. Walsh
Christopher A. Walsh Howard Hughes Medical Institute
Shunichi Takeda
Shunichi Takeda Shenzhen University
Kevin Staras
Kevin Staras University of Sussex
Yves Pommier
Yves Pommier National Institutes of Health
Elsa Callen
Elsa Callen National Institutes of Health
Arjan P.M. de Brouwer
Arjan P.M. de Brouwer Radboud University
André Nussenzweig
André Nussenzweig National Institutes of Health

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