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Molecular Biology

D-Index
119
Citations
52924
World Ranking
269
National Ranking
159

Overview

Junjie Chen is affiliated with The University of Texas MD Anderson Cancer Center in the United States. Their research primarily focuses on biochemistry, genetics, molecular biology, and medicine, with particular interests in molecular biology, oncology, immunology, cancer research, and pulmonary and respiratory medicine.

The scientist's work covers several main research topics, including DNA repair mechanisms, CRISPR and genetic engineering, ubiquitin and proteasome pathways, RNA modifications and cancer, interferon and immune responses, cancer-related molecular mechanisms research, and ferroptosis and cancer prognosis.

Junjie Chen has contributed to numerous publications. Some of the recent notable papers include:

  • Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis (2023, Nature Cell Biology)
  • mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation (2021, Nature Communications)
  • Biological and clinical aspects of HPV-related cancers (2020, Cancer Biology and Medicine)
  • ATR inhibition potentiates ionizing radiation-induced interferon response via cytosolic nucleic acid-sensing pathways (2020, The EMBO Journal)
  • ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer (2022, Science Immunology)

Their frequent co-authors include Litong Nie, Mengfan Tang, Chao Wang, Xu Feng, and Huimin Zhang, indicating ongoing collaborative efforts.

Junjie Chen often publishes in venues such as Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, Research Square, Cancer Research, Journal of Clinical Immunology, and bioRxiv.

Best Publications

  • Association of BRCA1 with Rad51 in Mitotic and Meiotic Cells

    Ralph Scully;Junjie Chen;Annemieke Plug;Yonghong Xiao

  • Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress

    Irene M. Ward;Junjie Chen

  • Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

    Ralph Scully;Junjie Chen;Robert L Ochs;Kathleen Keegan

  • The BRCT Domain Is a Phospho-Protein Binding Domain

    Xiaochun Yu;Claudia Christiano Silva Chini;Miao He;Georges Mer

  • RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly.

    Michael S.Y. Huen;Robert Grant;Isaac Manke;Kay Minn

  • Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair

    Maria Victoria Botuyan;Joseph Lee;Irene M. Ward;Ja Eun Kim

  • Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha.

    Ji Hong Lim;Yoon Mi Lee;Yang Sook Chun;Junjie Chen

  • DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.

    Oscar Fernandez-Capetillo;Hua Tang Chen;Arkady Celeste;Irene Ward

  • MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals

    Zhenkun Lou;Katherine Minter-Dykhouse;Sonia Franco;Monica Gostissa

  • Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

    Junjie Chen;Daniel P. Silver;Deepika Walpita;Sharon B. Cantor

  • Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA

    Junjie Chen;Peter K. Jackson;Marc W. Kirschner;Anindya Dutta

  • BAP1 links metabolic regulation of ferroptosis to tumour suppression.

    Yilei Zhang;Jiejun Shi;Xiaoguang Liu;Li Feng

  • Genomic instability in laminopathy-based premature aging

    Baohua Liu;Jianming Wang;Kui Ming Chan;Wai Mui Tjia

  • Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response.

    Hongtae Kim;Junjie Chen;Xiaochun Yu

  • DBC1 is a negative regulator of SIRT1

    Ja Eun Kim;Junjie Chen;Zhenkun Lou

  • PALB2 is an integral component of the BRCA complex required for homologous recombination repair

    Shirley M. H. Sy;Michael S. Y. Huen;Junjie Chen

  • Tumor Suppressor P53 Binding Protein 1 (53bp1) Is Involved in DNA Damage–Signaling Pathways

    Irene Rappold;Kuniyoshi Iwabuchi;Takayasu Date;Junjie Chen

  • BRCA1 and its toolbox for the maintenance of genome integrity

    Michael S.Y. Huen;Shirley M.H. Sy;Junjie Chen

  • REV7 counteracts DNA double-strand break resection and affects PARP inhibition

    Guotai Xu;J. Ross Chapman;Inger Brandsma;Jingsong Yuan

  • p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice.

    Irene M. Ward;Kay Minn;Jan van Deursen;Junjie Chen

Frequent Co-Authors

Marina Artuso
Marina Artuso Syracuse University
Jonathan L. Rosner
Jonathan L. Rosner University of Chicago
John Yelton
John Yelton University of Florida
J. Napolitano
J. Napolitano Temple University
Daniel P Cronin-Hennessy
Daniel P Cronin-Hennessy University of Minnesota
E. H. Thorndike
E. H. Thorndike University of Rochester
R. Mountain
R. Mountain Syracuse University
Paul Avery
Paul Avery University of Florida

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